Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

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Role of HSPA2 chaperone protein in epidermis physiology and pathophysiology

2017/25/B/NZ4/01550

Keywords:

HSPA2 heat shock proteins epidermis keratinocyte homeostasis HIF-1 psoriasis reconstructed human epidermis in vitro model

Descriptors:

  • NZ4_2:
  • NZ1_8:
  • NZ3_1:

Panel:

NZ4 - Biology of tissues, organs and organisms: morphology and functions of animal's and human's systems, organs and organisms, experimental medicine, basics of neurology

Host institution :

Centrum Onkologii - Instytut im. Marii Skłodowskiej-Curie, Oddział w Gliwicach

woj. śląskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Dorota Bogumiła Ścieglińska 

Number of co-investigators in the project: 6

Call: OPUS 13 - announced on 2017-03-15

Amount awarded: 1 288 320 PLN

Project start date (Y-m-d): 2018-01-25

Project end date (Y-m-d): 2023-07-24

Project duration:: 66 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (6)
  • Book publications / chapters in book publications (1)
  1. Various Anti-HSPA2 Antibodies Yield Different Results in Studies on Cancer-Related Functions of Heat Shock Protein A2
    Authors:
    Dorota Scieglinska, Damian Robert Sojka, Agnieszka Gogler-Pigłowska, Vira Chumak, Zdzisław Krawczyk
    Academic press:
    International Journal of Molecular Sciences (rok: 2020, tom: 21(12), strony: 4296), Wydawca: MDBI
    Status:
    Published
    DOI:
    10.3390/ijms21124296 - link to the publication
  2. Synthesis and in vitro cytotoxicity evaluation of star-shaped polymethacrylic conjugates with methotrexate or acitretin as potential antipsoriatic prodrugs
    Authors:
    Anna Mielanczyk, KatarzynaMrowiec, Maria Kupczak, Łukasz Mielanczyk, Dorota Scieglinsk, Agnieszka Gogler-Piglowska, Marek Michalski, Andrzej Gabriel, Dorota Neugebauer, Magdalena Skonieczna
    Academic press:
    European Journal of Pharmacology (rok: 2020, tom: 866, strony: 172804), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.ejphar.2019.172804 - link to the publication
  3. HSPA2 Chaperone Contributes to the Maintenance of Epithelial Phenotype of Human Bronchial Epithelial Cells but Has Non-Essential Role in Supporting Malignant Features of Non-Small Cell Lung Carcinoma, MCF7, and HeLa Cancer Cells
    Authors:
    Damian Robert Sojka, Agnieszka Gogler-Piglowska, Katarzyna Klarzynska, Marta Klimczak, Alicja Zylicz, Magdalena Glowala-Kosinska, Zdzisław Krawczyk, Dorota Scieglinska
    Academic press:
    Cancers (rok: 2020, tom: 12, strony: 2749), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/cancers12102749 - link to the publication
  4. Heat Shock Protein A2 is a novel extracellular vesicle-associated protein
    Authors:
    Sojka DR, Abramowicz A, Adamiec-Organiściok M, Karnas E, Kania D, Mielańczyk Ł, Blamek S, Telka E, Scieglinska D
    Academic press:
    Scientific Reports (rok: 2023, tom: 13, strony: 4734), Wydawca: Springer Nature
    Status:
    Published
    DOI:
    10.1038/s41598-023-31962-5 - link to the publication
  5. Heat shock proteins in the physiology and pathophysiology of epidermal keratinocytes
    Authors:
    Dorota Scieglinska, Zdzisław Krawczyk, Damian Robert Sojka, Agnieszka Gogler-Pigłowska
    Academic press:
    Cell Stress and Chaperones (rok: 2019, tom: 24, strony: 1027-1044), Wydawca: Cell Stress Society International
    Status:
    Published
    DOI:
    10.1007/s12192-019-01044-5. - link to the publication
  6. EpidermaQuant: Unsupervised Detection and Quantification of Epidermal Differentiation Markers on H-DAB-Stained Images of Reconstructed Human Epidermis 1 of 43 EpidermaQuant: Unsupervised Detection and Quantification of Epidermal Differentiation Markers on H-DAB-Stained Images of Reconstructed Human Epidermis
    Authors:
    Dawid Zamojski, Agnieszka Gogler, Dorota Scieglinska, Michal Marczyk
    Academic press:
    Diagnostics (rok: 2024, tom: 14(17), strony: 1904), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/diagnostics14171904 - link to the publication
  1. A tool for quantifying the level of antigen (keratin 10) determined by the IHC method in human epithelial equivalents obtained in vitro
    Authors:
    Kostka D, Gogler-Pigłowska A, Płonka W, Sojka D, Adamiec-Organiściok M, Skonieczna M, Ścieglińska D
    Book:
    Recent Advances in Computational Oncology and Personalized Medicine (rok: 2022, tom: ISBN 987-83-7880-876-3, strony: 34-49), Wydawca: Wydawnictwo Politechniki Śląskiej
    Status:
    Published

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