Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

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Influence of administration of cathinones, on the example of mephedrone, in adolescence and on fenotype of adult rats - preclinical behavioral and neurochemical studies on matrix metaloproteinase-9 (MMP-9) in rats' brain.

2017/25/B/NZ7/01845

Keywords:

mephedrone adolescent rats MMP-9 MMP-9 endogenous tissue inhibitor behavior of animals adult rats

Descriptors:

  • NZ1_1: Molecular biology
  • NZ3_5: Molecular neurobiology
  • NZ7_14: Pharmacy, pharmacotherapy, pharmacology

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Uniwersytet Medyczny w Lublinie, Wydział Farmaceutyczny

woj. lubelskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Jolanta Kotlińska 

Number of co-investigators in the project: 9

Call: OPUS 13 - announced on 2017-03-15

Amount awarded: 852 120 PLN

Project start date (Y-m-d): 2018-02-21

Project end date (Y-m-d): 2022-02-20

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Pojemnik na ciekły azot (2 szt.) (6 000 PLN)
  2. Waga analityczna (15 000 PLN)
  3. Autoklaw (10 000 PLN)
  4. Komputer przenośny typu laptop.
  5. Waga do pomiaru masy ciała zwierząt (6 000 PLN)
  6. Zestaw komputerowy typu laptop z oprogramowaniem i drukarką (6 000 PLN)
  7. Robot stereotaktyczny w wersji bezprzewodowej (100 000 PLN)
  8. System Ugo-Basile aparatura do doświadczeń: NEW Fear Conditioning System – ANYmaze.
  9. Specjalistyczne oprogramowanie komputerowe: Graph PadPrism i Reference Menager (2 szt.) (8 000 PLN)

Information in the final report

  • Publication in academic press/journals (2)
  1. Alteration of Ethanol Reward by Prior Mephedrone Exposure: The Role of Age and Matrix Metalloproteinase‐9 (MMP‐9)
    Authors:
    Pawel Grochecki, Irena Smaga, Marta Marszalek-Grabska, Malgorzata Lopatynska-Mazurek, Tymoteusz Slowik, Ewa Gibula-Tarlowska, Ewa Kedzierska, Joanna Listos, Malgorzata Filip,Jolanta H. Kotlinska 1
    Academic press:
    International Journal of Molecular Sciences (rok: 2022, tom: vol. 23 nr 4, strony: 45306), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms23042122 - link to the publication
  2. Effects of Mephedrone and Amphetamine Exposure during Adolescence on Spatial Memory in Adulthood: Behavioral and Neurochemical Analysis
    Authors:
    Pawel Grochecki , Irena Smaga , Malgorzata Lopatynska-Mazurek, Ewa Gibula-Tarlowska, Ewa Kedzierska, Joanna Listos, Sylwia Talarek, Marta Marszalek-Grabska, Magdalena Hubalewska-Mazgaj, Agnieszka Korga-Plewko, Jaroslaw Dudka, Zbigniew Marzec, Małgorzata Filip and Jolanta H. Kotlinska
    Academic press:
    International Journal of Molecular Sciences (rok: 2021, tom: 22, strony: 589-608), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms22020589 - link to the publication

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