Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Whole-genome analysis of factors promoting instant and complex chromosome destabilizations in mitotically dividing diploid cells of Saccharomyces cerevisiae

2017/25/B/NZ2/01036

Keywords:

chromosomal mutations loss of heterozygosity aneuploidy chromothrypsis

Descriptors:

  • NZ2_1: Molecular genetics
  • NZ2_2: Genomics, transcriptomics, epigenomics
  • NZ2_5: Cell genetics

Panel:

NZ2 - Genetics, genomics: molecular genetics, genomics, proteomics, bioinformatics, systems biology, genetic epidemiology

Host institution :

Uniwersytet Jagielloński, Wydział Biologii i Nauk o Ziemi

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Ryszard Korona 

Number of co-investigators in the project: 4

Call: OPUS 13 - announced on 2017-03-15

Amount awarded: 1 135 150 PLN

Project start date (Y-m-d): 2018-01-30

Project end date (Y-m-d): 2023-01-29

Project duration:: 60 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Aparat do cytometrii przepływowej i zliczania komórek z podajnikiem Beckman CytoFLEX (175 000 PLN)
  2. Komputer osobisty (2 szt.) (10 000 PLN)
  3. Sonikator QSonica 96-pin (51 000 PLN)
  4. Komora nawiewu laminarnego powietrza sterylnego.
  5. Komputer osobisty (4 999 PLN)
  6. Stacja pipetowania Eppendorf 96-well pipettor (84 000 PLN)

Information in the final report

  • Publication in academic press/journals (4)
  1. Overexpression of a single ORF can extend chronological lifespan in yeast if retrograde signaling and stress response are stimulated
    Authors:
    Pogoda, E., Tutaj, H., Pirog, A., Tomala, K., & Korona, R.
    Academic press:
    Biogerontology (rok: 2021, tom: 22, strony: 415-427), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s10522-021-09924-z - link to the publication
  2. Genome-scale patterns in the loss of heterozygosity incidence in Saccharomyces cerevisiae
    Authors:
    Hanna Tutaj , Adrian Pirog , Katarzyna Tomala , and Ryszard Korona
    Academic press:
    Genetics (rok: 2022, tom: 221(1), strony: iyac032), Wydawca: Oxford University Press
    Status:
    Published
    DOI:
    10.1093/genetics/iyac032 - link to the publication
  3. Epistasis supports viability under extensive gene dose insufficiency following chromosome loss
    Authors:
    H. Tutaj, K. Tomala, R. Korona
    Academic press:
    eLife , Wydawca: eLife Sciences Publications Ltd
    Status:
    Accepted for publication
    DOI:
    10.1101/2023.03.12.532261 - link to the publication
  4. Gene overexpression screen for chromosome instability in yeast primarily identifies cell cycle progression genes
    Authors:
    Hanna Tutaj, Elzbieta Pogoda, Katarzyna Tomala, Ryszard Korona
    Academic press:
    Current Genetics (rok: 2018, tom: 2018, strony: 45301), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s00294-018-0885-x - link to the publication

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