Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

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An integrated screening platform for determination of human proteasomes extended substrate specificity

2017/25/B/ST5/00215

Keywords:

combinatorial chemistry protease chemical biology unnatural amino acids

Descriptors:

  • ST5_16:
  • ST5_23:

Panel:

ST5 - Materials: materials synthesis, structure-properties relations, advanced and functional materials with designed properties, (macro)molecular architecture, material engineering

Host institution :

Politechnika Wrocławska

woj. dolnośląskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Marcin Drąg 

Number of co-investigators in the project: 4

Call: OPUS 13 - announced on 2017-03-15

Amount awarded: 1 826 000 PLN

Project start date (Y-m-d): 2018-02-07

Project end date (Y-m-d): 2021-02-06

Project duration:: 36 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Chromatograf cieczowy połączony ze spektrometrią mas (LC-MS) (495 000 PLN)
  2. Komputer (8 000 PLN)

Information in the final report

  • Publication in academic press/journals (4)
  1. Applications of Unnatural Amino Acids in Protease Probes
    Authors:
    Izabela Małuch, Justyna Czarna, Marcin Drąg
    Academic press:
    Chemistry - An Asian Journal (rok: 2019, tom: 14, strony: 4103-4113), Wydawca: Wiley-VCH
    Status:
    Published
    DOI:
    10.1002/asia.201901152 - link to the publication
  2. Selective Substrates and Activity-Based Probes for Imaging of the Human Constitutive 20S Proteasome in Cells and Blood Samples
    Authors:
    Wioletta Rut, Marcin Poręba, Paulina Kasperkiewicz, Scott J. Snipas, Marcin Drąg
    Academic press:
    Journal of Medicinal Chemistry (rok: 2018, tom: 61, strony: 5222-5234), Wydawca: American Chemical Society
    Status:
    Published
    DOI:
    10.1021/acs.jmedchem.8b00026 - link to the publication
  3. Investigation of P1' and P2' sites of IQF substrates on their selectivity towards 20S proteasome subunits.
    Authors:
    Radoslaw Gladysz, Natalia Malek, Wioletta Rut, Marcin Drag
    Academic press:
    Biological Chemistry (rok: 2022, tom: N/A, strony: N/A), Wydawca: De Gruyter
    Status:
    Accepted for publication
    DOI:
    brak - link to the publication
  4. Protease Specificity: Towards In Vivo Imaging Applications and Biomarker Discovery
    Authors:
    Matej Vizovišek, Robert Vidmar, Marcin Drag, Marko Fonovic, Guy S. Salvesen, Boris Turk
    Academic press:
    Trends in Biochemical Sciences (rok: 2018, tom: 43, strony: 829-844), Wydawca: Cell Press
    Status:
    Published
    DOI:
    10.1016/j.tibs.2018.07.003 - link to the publication

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