Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Microfluidic SERS-based analysis of circulating tumor cells (CTCs) from blood samples - new diagnostic approach for "liquid biopsy".

2017/25/B/ST4/01109

Keywords:

circulating tumor cells SERS spectroscopy plasmonic structures microfluidic devices blood clinical chemometric analysis

Descriptors:

  • ST4_3: Molecular architecture and structure
  • ST4_6: Instrumental methods in chemistry
  • ST4_13: Solid-state chemistry, surface physicochemistry

Panel:

ST4 - Chemistry: physical chemistry/chemical physics, theoretical chemistry, analytical chemistry, inorganic chemistry, organic chemistry, method development

Host institution :

Instytut Chemii Fizycznej Polskiej Akademii Nauk

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Agnieszka Michota-Kamińska 

Number of co-investigators in the project: 4

Call: OPUS 13 - announced on 2017-03-15

Amount awarded: 913 600 PLN

Project start date (Y-m-d): 2018-09-03

Project end date (Y-m-d): 2022-03-02

Project duration:: 42 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Densytometr.
  2. Komora laminarna II klasy bezpieczeństwa (50 000 PLN)
  3. Komputer typu laptop (2 szt.) (12 000 PLN)
  4. Napylarka wysokopróżniowa Q150 TS.
  5. Sterowane komputerem pompy strzykawkowe (12 000 PLN)
  6. Aparat do elektoforezy.
  7. Drukarka 3D (20 000 PLN)

Information in the final report

  • Publication in academic press/journals (6)
  1. Brain tumour homogenates analysed by surface-enhanced Raman spectroscopy: Discrimination among healthy and cancer cells
    Authors:
    Aneta Aniela Kowalska, Sylwia Berus, Łukasz Szleszkowski, Agnieszka Kamińska, Alicja Kmiecik, Katarzyna Ratajczak-Wielgomas, Tomasz Jurek, Łukasz Zadka
    Academic press:
    Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy (rok: 2019, tom: 231, strony: 1386-1425), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.saa.2019.117769 - link to the publication
  2. Dielectrophoresis-Based SERS Sensor of Cancer Cells in Microfluidic Chips
    Authors:
    Tomasz R. Szymborski , Marta Czaplicka , Ariadna B. Nowicka , Joanna Trzci´nska-Danielewicz , Agnieszka Girstun and Agnieszka Kami´nska
    Academic press:
    Biosensors (rok: 2022, tom: 12/681, strony: 45311), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/bios12090681 - link to the publication
  3. SERS-based sensor for direct L-selectin level determination in plasma samples as alternative method of tumor detection
    Authors:
    A.A.Kowalska, A.B. Nowicka, T. Szymborski, P. Piecyk and A.Kamińska
    Academic press:
    Journal of Biophotonics (rok: 2021, tom: 14, strony: e202000318), Wydawca: Wiley
    Status:
    Published
    DOI:
    10.1002/jbio.202000318 - link to the publication
  4. Detection of Circulating Tumor Cells Using Membrane-Based SERS Platform: A New Diagnostic Approach for 'Liquid Biopsy"
    Authors:
    A. Kamińska, T. Szymborski, E. Witkowska, E. Kijeńska-Gawrońska, W. Świeszkowski, K. Niciński, J. Trzcińska-Danielewicz and A. Girstun,
    Academic press:
    Nanomaterials (rok: 2019, tom: 9, strony: 45306), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/nano9030366 - link to the publication
  5. Detection of circulating tumor cells in blood by shell-isolated nanoparticle – enhanced Raman spectroscopy (SHINERS) in microfluidic device
    Authors:
    Krzysztof Niciński, Jan Krajczewski, Andrzej Kudelski, Evelin Witkowska, Joanna Trzcińska-Danilewicz, Agnieszka Girstun, and Agnieszka Kamińska
    Academic press:
    Scientific Report (rok: 2019, tom: 9, strony: 45347), Wydawca: Nature
    Status:
    Published
    DOI:
    10.1038/s41598-019-45629-7 - link to the publication
  6. Effect of Varying Expression of EpCAM on the Efficiency of CTCs Detection by SERS-Based Immunomagnetic Optofluidic Device
    Authors:
    Marta Czaplicka, Krzysztof Niciński, Ariadna Nowicka, Tomasz Szymborski, Izabela Chmielewska, Joanna Trzcińska-Danielewicz, Agnieszka Girstun and Agnieszka Kamińska
    Academic press:
    Cancers (rok: 2020, tom: 12(11), strony: 3315), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/cancers12113315 - link to the publication

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