Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

Delete all

Thermodynamics of halogen bonding in the bio-molecular cage

2017/25/B/ST4/01613

Keywords:

halogen bond thermodynamics combinatorial chemistry (bio)molecular cage

Descriptors:

  • ST4_13: Solid-state chemistry, surface physicochemistry
  • NZ1_3: Biophysics

Panel:

ST4 - Chemistry: physical chemistry/chemical physics, theoretical chemistry, analytical chemistry, inorganic chemistry, organic chemistry, method development

Host institution :

Instytut Biochemii i Biofizyki Polskiej Akademii Nauk

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Jarosław Poznański 

Number of co-investigators in the project: 9

Call: OPUS 13 - announced on 2017-03-15

Amount awarded: 1 398 000 PLN

Project start date (Y-m-d): 2018-01-15

Project end date (Y-m-d): 2022-10-14

Project duration:: 57 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Oprogramowanie - Origin Pro (2 050 PLN)
  2. Aparatura umożliwiająca precyzyjne pomiary profili stabilności temperaturowej kompleksów bialko-ligand (220 000 PLN)
  3. Średniej klasy laptop z podstawowym oprogramowaniem (8 000 PLN)

Information in the final report

  • Publication in academic press/journals (7)
  • Articles in post-conference publications (6)
  1. 5,6-diiodo-1H-benzotriazole – new TBBt analogue that minutely affects mitochondrial activity.
    Authors:
    Paprocki D,* Winiewska-Szajewska M, Speina E, Kucharczyk R, Poznański J*
    Academic press:
    Scientific Reports (rok: 2021, tom: 11, strony: 23701), Wydawca: Nature Publishing Group
    Status:
    Published
    DOI:
    10.1038/s41598-021-03136-8 - link to the publication
  2. Competition between electrostatic interactions and halogen bonding in the protein–ligand system: structural and thermodynamic studies of 5,6-dibromobenzotriazole-hCK2α complexes
    Authors:
    Winiewska-Szajewska M*, Czapinska H, Kaus-Drobek M, Fricke A, Mieczkowska K, Dadlez M, Bochtler M, Poznański J*
    Academic press:
    Scientific Reports (rok: 2022, tom: 12, strony: 18964), Wydawca: Nature Publishing Group
    Status:
    Published
    DOI:
    10.1038/s41598-022-23611-0 - link to the publication
  3. Thermodynamic contribution of iodine atom to the binding of heterogeneously polyhalogenated benzotriazoles by the catalytic subunit of human protein kinase CK2
    Authors:
    Marzec, Ewa; Poznanski, Jaroslaw; Paprocki, Daniel
    Academic press:
    IUBMB LIFE (rok: 2020, tom: 72, strony: 1203-1210), Wydawca: WILEY
    Status:
    Published
    DOI:
    10.1002/iub.2257 - link to the publication
  4. Does the partial molar volume of a solute reflect the free energy of hydrophobic solvation?
    Authors:
    Szymaniec-Rutkowska, A ; Bugajska, E ; Kasperowicz, S ; Mieczkowska, K; Maciejewska, AM ; Poznanski, J
    Academic press:
    JOURNAL OF MOLECULAR LIQUIDS (rok: 2019, tom: 293, strony: 1-11 (111527)), Wydawca: ELSEVIER
    Status:
    Published
    DOI:
    10.1016/j.molliq.2019.111527 - link to the publication
  5. The Halogenation of Natural Flavonoids, Baicalein and Chrysin, Enhances Their Affinity to Human Protein Kinase CK2.
    Authors:
    Marzec E, Świtalska M, Winiewska-Szajewska M, Wójcik J, Wietrzyk J, Maciejewska AM, Poznański J, Mieczkowski A
    Academic press:
    IUBMB life (rok: 2020, tom: 72, strony: 1250-1261), Wydawca: WILEY
    Status:
    Published
    DOI:
    10.1002/iub.2298 - link to the publication
  6. Halogen Atoms in the Protein−Ligand System. Structural and Thermodynamic Studies of the Binding of Bromobenzotriazoles by the Catalytic Subunit of Human Protein Kinase CK2
    Authors:
    Honorata Czapinska, Maria Winiewska-Szajewska, Anna Szymaniec-Rutkowska, Anna Piasecka, Matthias Bochtler, Jarosław Poznanski
    Academic press:
    Journal of Physical Chemistry B (rok: 2021, tom: 125, strony: 2491-2503), Wydawca: ACS
    Status:
    Published
    DOI:
    10.1021/acs.jpcb.0c10264 - link to the publication
  7. Synthesis of novel halogenated heterocycles based on o-phenylenediamine and their interactions with the catalytic subunit of protein kinase CK2.
    Authors:
    Winiewska-Szajewska M, Maciejewska AM, Poznański J,* Paprocki D*
    Academic press:
    Molecules (rok: 2021, tom: 26, strony: 3163), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/molecules26113163 - link to the publication
  1. Thermodynamic contribution of iodine to protein-ligand interactions: synthesis of heterogeneously halogenated benzotriazoles and their binding to the catalytic subunit of human protein kinase CK2
    Authors:
    Ewa Bugajska, Jarosław Poznański, Daniel Paprocki
    Conference:
    2019 IUBMB Focused Meeting; 10th Inhibitors of Protein Kinases Conference joined with the 2nd Challenges in Molecular Biology, Biophysics and Biomedicine Meeting (rok: 2019, ), Wydawca: Institute of Biochemistry and Biophysics Polish Academy of Science
    Data:
    konferencja 43722
    Status:
    Published
  2. Does the ionic state of the solute affect organization of the solvation shell? Study of the pH-dependence of experimentally measured partial molar volume of 1Hbenzotriazole
    Authors:
    A. Stefaniuk, A. Szymaniec-Rutkowska, J. Poznanski
    Conference:
    44th FEBS Congress (rok: 2019, ), Wydawca: Wiley (FEBS OpenBio)
    Data:
    konferencja 43652
    Status:
    Published
  3. Halogen bonding in protein-ligand systems. Application of site-directed mutagenesis of the ATP binding site of the catalytic subunit of the protein kinase CK2.
    Authors:
    Bugajska E.
    Conference:
    6th International Iberian Biophysics Congress and X Iberoamerican Congress of Biophysics. (rok: 2018, ), Wydawca: Universitat Jaume I
    Data:
    konferencja 20-22.06.18
    Status:
    Published
  4. Isotope effect in solute-solvent interactions
    Authors:
    Anna Stefaniuk, Sylwester Gawinkowski, Barbara Golec, Aleksander Gorski, Jacek Waluk, Jarosław Poznański,
    Conference:
    24th International Conference on Horizons in Hydrogen Bond Research; Bilbao Spain 12-15 September 2022; poster (rok: 2022, ), Wydawca: Universidad del Pais Vasco
    Data:
    konferencja 12-15 September
    Status:
    Published
  5. Thermal shift assay evaluates the binding of brominated benzotriazoles by rationally selected variants of the catalytic subunit of human protein kinase CK2.
    Authors:
    Bugajska E., Winiewska M., Poznański J.
    Conference:
    Polish Photoscience Seminar 2018 (rok: 2018, ), Wydawca: Institute of Physical Chemistry
    Data:
    konferencja 11-14 VI 2018
    Status:
    Published
  6. Halogenation of natural flavonoids enhances their affinity to human protein kinase CK2
    Authors:
    Ewa Bugajska, Jarosław Poznański, Adam Mieczkowski
    Conference:
    2019 IUBMB Focused Meeting; 10th Inhibitors of Protein Kinases Conference joined with the 2nd Challenges in Molecular Biology, Biophysics and Biomedicine Meeting (rok: 2019, ), Wydawca: Institute of Biochemistry and Biophysics Polish Academy of Science
    Data:
    konferencja 43722
    Status:
    Published

O Narodowym Centrum Nauki

Finansowanie nauki

Współpraca zagraniczna

Centrum prasowe

Deklaracja dostępności
Przetwarzanie danych osobowych
Polityka cookies

Partnerzy