Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Solid state NMR spectroscopy as a tool supporting mechanochemistry development

2017/25/B/ST4/02684

Keywords:

Mechanochemistry mechanosynthesis Solid State NMR NMR Crystallography pharmaceutical cocrystals peptides

Descriptors:

  • ST4_3: Molecular architecture and structure
  • ST4_11: Coordination and supramolecular chemistry
  • ST4_4: Theoretical and computational chemistry

Panel:

ST4 - Chemistry: physical chemistry/chemical physics, theoretical chemistry, analytical chemistry, inorganic chemistry, organic chemistry, method development

Host institution :

Centrum Badań Molekularnych i Makromolekularnych Polskiej Akademii Nauk

woj. łódzkie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Marek Potrzebowski 

Number of co-investigators in the project: 5

Call: OPUS 13 - announced on 2017-03-15

Amount awarded: 1 207 600 PLN

Project start date (Y-m-d): 2018-01-19

Project end date (Y-m-d): 2023-01-18

Project duration:: 60 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Komputer stacjonarny z oprogramowaniem (Windows, Microsoft Oficce, Gauss View, Corel) (5 000 PLN)
  2. Zestaw komputerowy.
  3. modernizacja głowicy MASDVT.
  4. Modyfikacja sondy CP-MAS 1.3mm H/BB (60 000 PLN)
  5. Naczynia mielące do młyna.
  6. Młyn planetarno - kulowy z akcesoriami (naczynia reakacyjne, kule mielące itp.) (100 000 PLN)

Information in the final report

  • Publication in academic press/journals (9)
  • Book publications / chapters in book publications (1)
  1. Porous Molecular Capsules as Non-Polymeric Transducers of Mechanical Forces to Mechanophores
    Authors:
    Hanna Jędrzejewska, Ewelina Wielgus, Sławomir Kaźmierski, Halina Rogala, Michał Wierzbicki, Aneta Wróblewska, Tomasz Pawlak, Marek J. Potrzebowski, Agnieszka Szumna
    Academic press:
    Chemistry A European Journal (rok: 2020, tom: 26, strony: 1558-1566), Wydawca: Wiley-VCH
    Status:
    Published
    DOI:
    10.1002/chem.201904024. - link to the publication
  2. Expedient synthesis of N –Oxy-Heterocyclic Carbenes (NOHC) ligands and metal complexes using mechanochemistry
    Authors:
    Aneta Wróblewska, Gaëtan Lauriol, Grzegorz Mlostoń , Xavier Bantreilc , Frédéric Lamaty
    Academic press:
    Journal of Organometallic Chemistry (rok: 2021, tom: 949, strony: 121914-121920), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.jorganchem.2021.121914 - link to the publication
  3. Cocrystals Divorce and Marriage": When a Binary System Meets an Active Multifunctional Synthon in a Ball Mill
    Authors:
    Marta K. Dudek, Justyna Śniechowska, Aneta Wróblewska, Sławomir Kaźmierski
    Academic press:
    Chemistry A European Journal (rok: 2020, tom: 26, strony: 13264-13273), Wydawca: Wiley-VCH GmbH
    Status:
    Published
    DOI:
    10.1002/chem.202002238 - link to the publication
  4. Understanding the formation of apremilast cocrystals
    Authors:
    Marta K. Dudek, Ewelina Wielgus, Piotr Paluch, Justyna Śniechowska, Maciej Kostrzewa, Graeme M. Day, Grzegorz D. Bujacz, Marek J. Potrzebowski
    Academic press:
    Acta Crystallographica Section B (rok: 2019, tom: B75, strony: 803-814), Wydawca: Wiley: IUCr Journals
    Status:
    Published
    DOI:
    10.1107/S205252061900917X - link to the publication
  5. Virtual Cocrystal Screening Methods as Tools to Understand the Formation of Pharmaceutical CocrystalsA Case Study of Linezolid, a Wide-Range Antibacterial Drug
    Authors:
    Mehrnaz Khalaji, Marek J. Potrzebowski, Marta K. Dudek
    Academic press:
    Cryst. Growth Des. (rok: 2021, tom: 21, strony: 2301-2314), Wydawca: ACS
    Status:
    Published
    DOI:
    10.1021/acs.cgd.0c01707 - link to the publication
  6. tructural variety of heterosynthons in linezolid cocrystals with modified thermal properties
    Authors:
    Mehrnaz Khalaji, Aneta Wróblewska, Ewelina Wielgus, Grzegorz D. Bujacz, Marta K. Dudek, Marek J. Potrzebowski
    Academic press:
    Acta Crystallographica Section B (rok: 2020, tom: 76, strony: 892-912), Wydawca: Wiley: IUCr Journals
    Status:
    Published
    DOI:
    10.1107/S2052520620010896 - link to the publication
  7. A new look at the mechanism of cocrystal formation and coformers exchange in processes forced by mechanical and/or thermal stimuli - ex situ and in situ studies of low-melting eutectic mixtures.
    Authors:
    Marta K. Dudek, Katarzyna Trzeciak, Justyna Zając, Sławomir Kaźmierski, Edyta Pindelska and Marek J. Potrzebowski
    Academic press:
    Chmistry A European Journal (rok: 2023, ), Wydawca: Wiley
    Status:
    Submitted
    DOI:
    brak - link to the publication
  8. Application of 1-Hydroxy-4,5-Dimethyl-Imidazole 3-Oxide as Coformer in Formation of Pharmaceutical Cocrystals
    Authors:
    Aneta Wróblewska, Justyna Śniechowska, Sławomir Kaźmierski, Ewelina Wielgus, Grzegorz D. Bujacz, Grzegorz Mlostoń, Arkadiusz Chworoś, Justyna Suwara, Marek J. Potrzebowski
    Academic press:
    Pharmaceutics (rok: 2020, tom: 12(4), strony: 359), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/pharmaceutics12040359 - link to the publication
  9. π‑Philic Molecular Recognition in the Solid State as a Driving Forcefor Mechanochemical Formation of Apremilast Solvates andCocrystals
    Authors:
    Marta K. Dudek, Maciej Kostrzewa, Piotr Paluch, Marek J. Potrzebowski
    Academic press:
    Crystal Growth & Design (rok: 2018, tom: 18, strony: 3959-3970), Wydawca: ACS
    Status:
    Published
    DOI:
    10.1021/acs.cgd.8b00301 - link to the publication
  1. Fast and very fast MAS solid state NMR studies of pharmaceuticals
    Authors:
    Marta K.Dudek, SławomirKaźmierski, Marek J.Potrzebowski
    Book:
    Annual Reports on NMR Spectroscopy (rok: 2021, tom: 103, strony: 97-189), Wydawca: Elsevier
    Status:
    Published

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