Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Requirement of conserved folding catalysts in the functionality of several essential proteins, metabolic pathways and key virulence factors

2017/25/B/NZ6/02021

Keywords:

peptidyl prolyl isomerase cyclophilin parvulin FK506 IspH FabZ

Descriptors:

  • NZ6_4: Bacteriology
  • NZ1_10: Microbiology
  • NZ2_1: Molecular genetics

Panel:

NZ6 - Human and animal immunology and infection: immunity, immune disorders, immunotherapy, infectious and invasive diseases, microbiology, transplantology, allergology

Host institution :

Politechnika Gdańska, Wydział Chemiczny

woj. pomorskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Satish Raina 

Number of co-investigators in the project: 5

Call: OPUS 13 - announced on 2017-03-15

Amount awarded: 1 315 084 PLN

Project start date (Y-m-d): 2018-01-03

Project end date (Y-m-d): 2021-07-02

Project duration:: 42 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. spektrofotometr UV/VIS z kontrolowaną temperaturą.
  2. wytrząsarka powietrzna z kontrolowaną temperaturą.
  3. Aparatura do pomiaru powinowactwa wiązania w oddziaływaniach białko-białko techniką izotermicznego miareczkowania kalorymetrycznego (ITC) (475 000 PLN)
  4. system do pomiaru syntezy DNA w czasie rzeczywistym (real-time PCR system).

Information in the final report

  • Publication in academic press/journals (6)
  1. Multicopy suppressor analysis of strains lacking cytoplasmic peptidyl-prolyl cis/trans isomerases identifies three new PPIase activities in Escherichia coli that includes the DksA transcription factor
    Authors:
    Pawel Wojtkiewicz, Daria Biernacka, Patrycja Gorzelak, Anna Stupak, Gracjana Klein and Satish Raina
    Academic press:
    International Journal of Molecular Sciences (rok: 2020, tom: 21, strony: E5843), Wydawca: MDPI Basel, Switzerland
    Status:
    Published
    DOI:
    10.3390/ijms21165843 - link to the publication
  2. Identification of substrates of cytoplasmic peptidyl-prolyl cis/trans isomerases and their collective essentiality in Escherichia coli
    Authors:
    Gracjana Klein, Pawel Wojtkiewicz, Daria Biernacka, Anna Stupak, Patrycja Gorzelak and Satish Raina
    Academic press:
    International Journal of Molecular Sciences (rok: 2020, tom: 21, strony: E4212), Wydawca: MDPI Basel, Switrzerland
    Status:
    Published
    DOI:
    10.3390/ijms21124212 - link to the publication
  3. Molecular basis of essentiality of early critical steps in the lipopolysaccharide biogenesis in Escherichia coli K-12: requirement of MsbA, cardiolipin, LpxL, LpxM and GcvB
    Authors:
    Patrycja Gorzelak, Gracjana Klein and Satish Raina
    Academic press:
    International Journal of Molecular Sciences (rok: 2021, tom: 22, strony: E5099), Wydawca: MDPI Basel, Switzerland
    Status:
    Published
    DOI:
    10.3390/ijms22105099 - link to the publication
  4. Checkpoints that regulate balanced biosynthesis of lipopolysaccharide and its essentiality in Escherichia coli
    Authors:
    Gracjana Klein, Alicja Wieczorek, Martyna Szuster and Satish Raina
    Academic press:
    International Journal of Molecular Sciences (rok: 2022, tom: 23, strony: 189), Wydawca: MDPI Basel, Switzerland
    Status:
    Published
    DOI:
    10.3390/ijms23010189 - link to the publication
  5. Regulated assembly of LPS, its structural alterations and cellular response to LPS defect
    Authors:
    Gracjana Klein and Satish Raina
    Academic press:
    International Journal of Molecular Sciences (rok: 2019, tom: 20, strony: E356), Wydawca: MDPI Basel, Switzerland
    Status:
    Published
    DOI:
    10.3390/ijms20020356 - link to the publication
  6. Regulation of the first committed step in lipopolysaccharide biosynthesis catalyzed by LpxC requires the essential protein LapC (YejM) and HslVU protease
    Authors:
    Daria Biernacka, Patrycja Gorzelak, Gracjana Klein and Satish Raina
    Academic press:
    International Journal of Molecular Sciences (rok: 2020, tom: 21, strony: E9088), Wydawca: MDPI Basel, Switzerland
    Status:
    Published
    DOI:
    10.3390/ijms21239088 - link to the publication

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