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Information on the principal investigator and host institution

Information of the project and the call

Keywords

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Investigations of immunomodulatory properties of the heat shock protein 70 (Hsp70) in autoimmune skin diseases

2017/25/B/NZ6/00305

Keywords:

Hsp70 autoimmune skin diseases animal model immunotherapy

Descriptors:

  • NZ6_1: Adaptive and innate immunity

Panel:

NZ6 - Human and animal immunology and infection: immunity, immune disorders, immunotherapy, infectious and invasive diseases, microbiology, transplantology, allergology

Host institution :

Uniwersytet Gdański, Wydział Biologii

woj. pomorskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Stefan Tukaj 

Number of co-investigators in the project: 3

Call: OPUS 13 - announced on 2017-03-15

Amount awarded: 902 400 PLN

Project start date (Y-m-d): 2018-01-19

Project end date (Y-m-d): 2022-01-18

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Cytometr przepływowy (250 000 PLN)

Information in the final report

  • Publication in academic press/journals (11)
  1. Autologous extracellular Hsp70 exerts a dual role in rheumatoid arthritis.
    Authors:
    Tukaj S, Mantej J, Sobala M, Potrykus K, Sitko K.
    Academic press:
    Cell Stress Chaperones. (rok: 2020, tom: 25(6), strony: 1105-1110), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s12192-020-01114-z - link to the publication
  2. Bullous pemphigoid anti-BP180-NC16A autoantibody reactivity in healthy individuals is associated with marked hypovitaminosis D and Th2-like cytokine predominance
    Authors:
    Tukaj S, Bieber K, Prüßmann W, Prüßmann JN, Schmidt E, Zillikens D, Ludwig RJ, Kasperkiewicz M.
    Academic press:
    Archives of Dermatological Research (rok: 2022, tom: Epub ahead of print., strony: Epub ahead of print.), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s00403-022-02386-4 - link to the publication
  3. Case Report: Circulating Anti-SARS-CoV-2 Antibodies Do Not Cross-React With Pemphigus or Pemphigoid Autoantigens
    Authors:
    Kasperkiewicz M, Bednarek M, Tukaj S.
    Academic press:
    Front Med (Lausanne). (rok: 2021, tom: 8, strony: 807711), Wydawca: Frontiers
    Status:
    Published
    DOI:
    10.3389/fmed.2021.807711. - link to the publication
  4. Heat shock proteins in the therapy of autoimmune diseases: too simple to be true?
    Authors:
    Tukaj S, Kaminski M.
    Academic press:
    Cell Stress Chaperones. (rok: 2019, tom: 24, strony: 475-479.), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s12192-019-01000-3. - link to the publication
  5. Vitamin D in autoimmune bullous disease.
    Authors:
    Tukaj S.
    Academic press:
    Acta Biochim Pol. (rok: 2020, tom: Ahead of print, strony: Ahead of print), Wydawca: Acta Biochim Pol.
    Status:
    Published
    DOI:
    10.18388/abp.2020_2905. - link to the publication
  6. Pathological relevance of anti-Hsp70 IgG autoantibodies in epidermolysis bullosa acquisita
    Authors:
    Tukaj S*, Mantej J, Sitko K, Zillikens D, Ludwig RJ, Bieber K, Kasperkiewicz M.
    Academic press:
    Frontiers in Immunology (rok: 2022, tom: 13, strony: 877958), Wydawca: Frontiers
    Status:
    Published
    DOI:
    0.3389/fimmu.2022.877958 - link to the publication
  7. Autoantibodies to heat shock proteins 60, 70, and 90 in patients with rheumatoid arthritis.
    Authors:
    Mantej J, Polasik K, Piotrowska E, Tukaj S.
    Academic press:
    Cell Stress Chaperones. (rok: 2019, tom: 24, strony: 283-287), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s12192-018-0951-9. - link to the publication
  8. Evidence for a role of extracellular heat shock protein 70 in epidermolysis bullosa acquisita
    Authors:
    Tukaj S, Mantej J, Sitko K, Bednarek M, Zillikens D, Ludwig RJ, Bieber K, Kasperkiewicz M.
    Academic press:
    Exp Dermatol. (rok: 2021, tom: Ahead of print, strony: Online ahead of print.), Wydawca: Wiley
    Status:
    Published
    DOI:
    10.1111/exd.14495. - link to the publication
  9. Therapeutic Implications of Targeting Heat Shock Protein 70 by Immunization or Antibodies in Experimental Skin Inflammation
    Authors:
    Stefan Tukaj, Jagoda Mantej, Michał Sobala, Katarzyna Potrykus, Zbigniew Tukaj, Detlef Zillikens, Ralf J. Ludwig, Katja Bieber, Michael Kasperkiewicz
    Academic press:
    Front. Immunol. (rok: 2021, tom: 12, strony: 614320), Wydawca: Frontiers
    Status:
    Published
    DOI:
    10.3389/fimmu.2021.614320 - link to the publication
  10. Autoantibodies to heat shock protein 60, 70, and 90 are not altered in the anti-SARS-CoV-2 IgG-seropositive humans without or with mild symptoms
    Authors:
    Mantej J, Bednarek M, Sitko K, Świętoń M, Tukaj S.
    Academic press:
    Cell Stress Chaperones (rok: 2021, tom: 26, strony: 735-740), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s12192-021-01215-3 - link to the publication
  11. Heat Shock Protein 70 as a Double Agent Acting Inside and Outside the Cell: Insights into Autoimmunity
    Authors:
    Stefan Tukaj
    Academic press:
    Int J Mol Sci. (rok: 2020, tom: 21(15), strony: 5298), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms21155298. - link to the publication

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