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Keywords

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Comparative effects of 1-methyl-1,2,3,4-tetrahydroisoquinoline (1MeTIQ) and olanzapine on the cognitive dysfunction measured in animal models of schizophrenia.

2017/25/B/NZ7/01096

Keywords:

schizophrenia 1MeTIQ antipsychotic activity

Descriptors:

  • NZ7_14: Pharmacy, pharmacotherapy, pharmacology

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Agnieszka Wąsik 

Number of co-investigators in the project: 10

Call: OPUS 13 - announced on 2017-03-15

Amount awarded: 1 067 965 PLN

Project start date (Y-m-d): 2018-01-19

Project end date (Y-m-d): 2021-10-18

Project duration:: 45 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Oprogramowanie do pomiaru behawioru wraz z kamerą i komputerem (40 000 PLN)
  2. pompa infuzyjna (20 000 PLN)

Information in the final report

  • Publication in academic press/journals (4)
  • Articles in post-conference publications (7)
  • Book publications / chapters in book publications (1)
  1. 1MeTIQ and olanzapine, despite their neurochemical impact, did not ameliorate performance in fear conditioning and social interaction tests in an MK-801 rat model of schizophrenia
    Authors:
    Magdalena Białoń 1, Agnieszka Chocyk 2, Iwona Majcher-Maślanka 2, Marcelina Żarnowska 1, Krzysztof Michalski 1, Lucyna Antkiewicz-Michaluk 1, Agnieszka Wąsik 3
    Academic press:
    Pharmacological Reports (rok: 2021, tom: 73, strony: 490–505), Wydawca: SPRINGER
    Status:
    Published
    DOI:
    10.1007/s43440-020-00209-9. - link to the publication
  2. Comparison of the effects of 1MeTIQ and olanzapine on performance in the elevated plus maze test and monoamine metabolism in the brain after ketamine treatment
    Authors:
    Agnieszka Wąsik, Magdalena Białoń, Marcelina Żarnowska, Lucyna Antkiewicz-Michaluk
    Academic press:
    Pharmacology, Biochemistry and Behavior (rok: 2019, tom: 181, strony: 17-27), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.pbb.2019.04.002. - link to the publication
  3. Pro-cognitive effect of 1MeTIQ on recognition memory in the ketamine model of schizophrenia in rats: the behavioural and neurochemical effects.
    Authors:
    Białoń M, Żarnowska M, Antkiewicz-Michaluk L, Wąsik A
    Academic press:
    Psychopharmacology (rok: 2020, tom: brak, strony: brak), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s00213-020-05484-1. - link to the publication
  4. The impact of the combined administration of 1MeTIQ and MK-801 on cell viability, oxidative stress markers and glutamate release in the rat hippocampus
    Authors:
    Agnieszka Wąsik1, Magdalena Białoń1, Danuta Jantas2, Marcelina Żarnowska1
    Academic press:
    Neurotoxicity Research (rok: 2021, tom: brak, strony: brak), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s12640-021-00428-9 - link to the publication
  1. The effect of chronic treatment with 1MeTIQ on frontal and hippocampal BDNF and PSD-95 level in rat model of schizophrenia
    Authors:
    Magdalena Białoń, Agnieszka Wąsik
    Conference:
    FENS regional meeting (rok: 2021, ), Wydawca: Elsevier
    Data:
    konferencja 25-27 sierpnia 2021
    Status:
    Published
  2. The impact of MK-801 and 1MeTIQ on the activity of antioxidant enzymes in the rat's hippocampus
    Authors:
    Agnieszka Wąsik, Magdalena Białoń
    Conference:
    CEBC (rok: 2021, ), Wydawca: Springer
    Data:
    konferencja 7-9 czerwca 2021
    Status:
    Published
  3. Changes in the activity of both serotonergic and glutamatergic systems after treatment 1MeTIQ tested in animal model of schizophrenia
    Authors:
    Agnieszka Wąsik, Magdalena Białoń, Marcelina Żarnowska
    Conference:
    FENS regional meeting (rok: 2021, ), Wydawca: Elsevier
    Data:
    konferencja 25-27 sierpnia 2021
    Status:
    Published
  4. Comparison of the effects of acute dose of 1-MeTIQ and olanzapine in probabilistic learning test in MK-801-treated rats
    Authors:
    Magdalena Białoń, Agnieszka Wąsik, Karolina Noworyta-Sokołowska, Marcelina Żarnowska, Rafał Ryguła
    Conference:
    XX Kongres PTF (rok: 2019, ), Wydawca: Elsevier
    Data:
    konferencja 5-7.06.2019
    Status:
    Published
  5. The impact of multiple administration of 1MeTIQ on the rats behavior measured by probabilistic reversal-learning task
    Authors:
    Agnieszka Wąsik1, Karolina Noworyta-Sokołowska2, Magdalena Białoń1, Marcelina Żarnowska1, Rafał Ryguła2
    Conference:
    XX Kongres PTF (rok: 2019, ), Wydawca: Elsevier
    Data:
    konferencja 5-7.06.2019
    Status:
    Published
  6. 1MeTIQ reverses the behavioral schizophrenia-like symptoms produced by ketamine in rats
    Authors:
    Agnieszka Wąsik, Magdalena Białoń, Marta Hereta, Lucyna Antkiewicz-Michaluk
    Conference:
    3rd CEBC 2018 (rok: 2018, ), Wydawca: Elsevier
    Data:
    konferencja 15-18. 09. 2018
    Status:
    Published
    DOI:
    link to the publication
  7. The effect of chronic treatment with MK-801 and 1-methyl-1,2,3,4- tetrahydroisoqunoline on activity of antioxidative enzymes in rats' front al cortex
    Authors:
    Magdalena Białoń, Agnieszka Wąsik
    Conference:
    CEBC (rok: 2021, ), Wydawca: Springer
    Data:
    konferencja 7-9 czerwca 2021
    Status:
    Published
  1. Psychiatric disorders in animal models of schizophrenia
    Authors:
    Agnieszka Wąsik
    Book:
    Handbook of neurotoxicity (rok: 2021, tom: brak, strony: 45303), Wydawca: SPRINGER
    Status:
    Published

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