Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Oral supplementation of piglets with iron nanoparticles and liposomial iron as an innovative therapy in treating neonatal iron deficiency anemia: insight into molecular mechanisms of iron absorption.

2017/25/B/NZ9/01707

Keywords:

iron metabolism anaemia nanoparticles hepcidin piglets

Descriptors:

  • NZ9_2: Animal production
  • NZ5_8: Animal disease treatment
  • NZ4_2: Physiology

Panel:

NZ9 - Fundamentals of applied life sciences and biotechnology: agricultural, forestry, horticulture, animal production and fishery, food and nutrition sciences, industrial biosciences, environmental biotechnology and remediation

Host institution :

Instytut Genetyki i Hodowli Zwierząt Polskiej Akademii Nauk

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Rafał Starzyński 

Number of co-investigators in the project: 5

Call: OPUS 13 - announced on 2017-03-15

Amount awarded: 935 641 PLN

Project start date (Y-m-d): 2018-02-06

Project end date (Y-m-d): 2021-02-05

Project duration:: 36 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Analizator krwi zwierząt LaserCyte Dx (65 000 PLN)

Information in the final report

  • Publication in academic press/journals (8)
  • Articles in post-conference publications (6)
  1. Comparative Evaluation of Sucrosomial Iron and Iron Oxide Nanoparticles as Oral Supplements in Iron Deficiency Anemia in Piglets
    Authors:
    Mazgaj R, Lipiński P, Szudzik M, Jończy A, Kopeć Z, Stankiewicz AM, Kamyczek M, Swinkels D, Żelazowska B, Starzyński RR.
    Academic press:
    Int J Mol Sci. (rok: 2021, tom: 14;22(18), strony: 9930), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms22189930 - link to the publication
  2. Marginally reduced maternal hepatic and splenic ferroportin under severe nutritional iron deficiency in pregnancy maintains systemic iron supply
    Authors:
    Mazgaj R, Lipiński P, Edison ES, Bednarz A, Staroń R, Haberkiewicz O, Lenartowicz M, Smuda E, Jończy A, Starzyński RR.
    Academic press:
    American Journal of Haematology (rok: 2021, tom: x, strony: 45303), Wydawca: Wiley-Liss (United States)
    Status:
    Published
    DOI:
    10.1002/ajh.26152 - link to the publication
  3. Innovative oral sucrosomial ferric pyrophosphate-based supplementation rescues suckling piglets from iron deficiency anemia similarly to commonly used parenteral therapy with iron dextran.
    Authors:
    Mateusz Szudzik, Rafał Mazgaj, Paweł Lipiński, Robert Staroń, Aneta Jończy, Marek Pieszka2, Małgorzata Lenartowicz4, Aleksandra Bednarz, Marian Kamyczek, Coby Laarakkers, Dorine Swinkels, and Rafał R. Starzyński
    Academic press:
    Annals of Animal Science (rok: 2020, tom: 21, strony: 45305), Wydawca: Elsevier B.V.
    Status:
    Published
    DOI:
    10,2478/aoas-2020-0084 - link to the publication
  4. Iron Supplementation in Suckling Piglets: An Ostensibly Easy Therapy of Neonatal Iron Deficiency Anemia.
    Authors:
    Szudzik M, Starzyński RR, Jończy A, Mazgaj R, Lenartowicz M, Lipiński P
    Academic press:
    Pharmaceuticals (rok: 2019, tom: Jan 29;12(1):22, strony: 45303), Wydawca: MDPI, Basel, Switzerland
    Status:
    Published
    DOI:
    10.3390/ph12010022. - link to the publication
  5. Interaction between iron and omega-3 fatty acids metabolisms: where is the crosslink?
    Authors:
    Magdalena Ogłuszka, Paweł Lipiński, and Rafał Radosław Starzyński
    Academic press:
    Critical Reviews in Food Science and Nutrition (rok: 2020, tom: 23, strony: 45312), Wydawca: Taylor & Francis Group
    Status:
    Published
    DOI:
    10.1080/10408398.2020.1862047 - link to the publication
  6. Relationship between down-regulation of copper-related genes and decreased ferroportin protein level in the duodenum of iron-deficient piglets.
    Authors:
    Aneta Jończy, Rafał Mazgaj, Rafał Radosław Starzyński, Piotr Poznański, Mateusz Szudzik, Ewa Smuda, Marian Kamyczek, Paweł Lipiński
    Academic press:
    Nutrients (rok: 2020, tom: 13(1), strony: 104), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/nu13010104 - link to the publication
  7. Effect of oral supplementation of healthy pregnant sows with sucrosomial ferric pyrophosphate on maternal iron status and hepatic iron stores in newborn piglets.
    Authors:
    Rafał Mazgaj, Mateusz Szudzik, Paweł Lipiński, Aneta Jończy, Ewa Smuda, Marian Kamyczek, Beata Cieślak, Dorine Swinkels, Malgorzata Lenartowicz and Rafał R. Starzyński
    Academic press:
    Animals (rok: 2020, tom: 10, strony: 45309), Wydawca: MDPI ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
    Status:
    Published
    DOI:
    10.3390/ani10071113. - link to the publication
  8. Long-term effect of split iron dextran/hemoglobin supplementation on erythrocyte and iron status, growth performance, carcass parameters and meat quality of Polish Large White and 990 line pigs.
    Authors:
    Szudzik M., Lipiński P., Jończy A., Mazgaj R., Pieszka M., Kamyczek M., Smuda E., and Starzyński R.R.
    Academic press:
    Biological Trace Element Research (rok: 2019, tom: 8, strony: 45300), Wydawca: HUMANA PRESS INC 999 RIVERVIEW DRIVE SUITE 208, TOTOWA, NJ 07512 USA
    Status:
    Published
    DOI:
    10.1007/s12011-019-01950-w. - link to the publication
  1. Comparison of the therapeutical potential of oral Sucrosomial® Iron and parenteral iron dextran supplementations in neonatal iron deficiency anemia in pigs. Animal Genetics and Genomics, 2-4 July 2018, Olsztyn, Poland
    Authors:
    MATEUSZ SZUDZIK, PAWEŁ LIPIŃSKI, ROBERT STAROŃ, ANETA JOŃCZY, MAREK PIESZKA, MAŁGORZATA LENARTOWICZ, MATEUSZ OGÓREK, ALEKSANDRA BEDNARZ, MARIAN KAMYCZEK, AND RAFAŁ R. STARZYŃSKI
    Conference:
    Animal Genetics and Genomics (rok: 2018, ), Wydawca: Polskie Towarzystwo Genetyczne
    Data:
    konferencja 2-4 July 2018
    Status:
    Published
  2. Effect of orally Sucrosomial® iron and iron sulphate on sows during gestation on maternal iron status and piglets outcome.
    Authors:
    Mazgaj R., Szudzik M., Lipiński P., Jończy A., Kamyczek M., Starzyński R.
    Conference:
    EMBL 8th Congress of the International BioIron Society (rok: 2019, ), Wydawca: EMBL Heidelberg Germany
    Data:
    konferencja 5-10 May 2019
    Status:
    Published
  3. Żelazo liposomalne i nanocząstki żelaza jako innowacyjne suplementy w profilaktyce/terapii niedokrwistości u prosiąt – od KNOW do OPUS
    Authors:
    Starzyński R.R., Szudzik M., Lipiński P., Jończy A., Mazgaj R., Pieszka M., Kamyczek M., Smuda E.
    Conference:
    Konferencja podsumowująca KNOW "Zdrowe Zwierzę – Bezpieczna Żywność" (rok: 2019, ), Wydawca: Krajowy Naukowy Ośrodek Wiodący Konsorcjum Naukowe KNOW
    Data:
    konferencja 43805
    Status:
    Published
  4. Neonatal iron deficiency anemia in pigs: State of art, new oral procedures of IDA prevention using Heme and Sucrosomial® iron.
    Authors:
    RAFAŁ R. STARZYŃSKI, MATEUSZ SZUDZIK, EWA SMUDA, MAŁGORZATA LENARTOWICZ, MARIAN KAMYCZEK AND PAWEŁ LIPIŃSKI
    Conference:
    14th International Symposium on Digestive Physiology of Pigs (rok: 2018, ), Wydawca: DPP
    Data:
    konferencja 21st and the 24th of August 2018
    Status:
    Published
  5. Long-term effect of innovative iron supplementation on iron status and slaughter performance in 990 line and Polish Landrace (PL) pigs.
    Authors:
    Szudzik M., Lipiński P., Smuda E., Lenartowicz M., Bednarz A., Kamyczek M. and Starzyński R.R.
    Conference:
    Animal Genetics and Genomics (rok: 2018, ), Wydawca: University of Warmia and Mazury in Olsztyn
    Data:
    konferencja 2nd-4th July
    Status:
    Published
  6. Iron deficiency anemia (IDA) in young piglets negatively affects growth and development of skeletal muscle.
    Authors:
    Szudzik M., Lipinski P., Jonczy A., Mazgaj R., Starzynski R.
    Conference:
    EMBL 8th Congress of the International BioIron Society (rok: 2019, ), Wydawca: EMBL Heidelberg Germany
    Data:
    konferencja 5-10 May 2019
    Status:
    Published

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