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Spontaneous senescence of ovarian cancer cells as an underestimated determinant of tumor progression: research on in vitro and in vivo models

2017/25/B/NZ3/00122

Keywords

Descriptors

  • NZ3_4: Starzenie
  • NZ5_3: Patogeneza chorób człowieka
  • NZ3_1: Biologia komórki

Panel

NZ3 – Cellular and developmental biology: cell biology, developmental biology, ageing biology, neurobiology

Host institution

Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu, Wydział Medyczny

Voivodeship: wielkopolskie

Other projects carried out by the institution »

Principal investigator (from the host institution)

prof. Krzysztof Stefan Książek

Number of co-investigators in the project: 9

Call

OPUS 13 – announced on 2017-03-15

Amount awarded
1 393 120 PLN
Project start date
2018-04-03
Project end date
2021-12-02
Project duration
44 months (the same as in the proposal)
Project status
Project settled

Project description

Download the project description in a pdf file

Note — project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Cytometr przepływowy.
  2. Czytnik wieloznacznikowy.
  3. Homogenizator ultradzwiękowy. Cost: 15 000 PLN
  4. Komora laminarna.
  5. Licznik komórek.
  6. System obrazowania komórek.
  7. Wielofunkcyjny czytnik płytek. Cost: 160 000 PLN
  8. Zamrażarka niskotemperaturow a z akcesoriami. Cost: 55 000 PLN
  9. Zestaw do eutanazji zwierząt za pomocą CO2.

Information in the final report

Publication in academic press/journals (9)

  1. Comprehensive review on how platinum- and taxane-based chemotherapy of ovarian cancer affects biology of normal cells

    Authors:
    Mikuła-Pietrasik J, Witucka A, Pakuła M, Uruski P, Begier-Krasińska B, Niklas A, Tykarski A, Książek K.
    Academic press:
    Cellular & Molecular Life Sciences (year: 2019, volume: 76, pages: 681-697), Publisher: Springer
    Status:
    Published
    DOI:
    10.1007/s00018-018-2954-1 – link to the publication

  2. Mechanisms and significance of therapy-induced and spontaneous senescence of cancer cells

    Authors:
    Mikuła-Pietrasik J, Niklas A, Uruski P, Tykarski A, Książek K.
    Academic press:
    Cellular and Molecular Life Sciences (year: 2020, volume: 77, pages: 213-229), Publisher: Springer
    Status:
    Published
    DOI:
    10.1007/s00018-019-03261-8 – link to the publication

  3. Deciphering the molecular mechanism of spontaneous senescence of primary epithelial ovarian cancer cells

    Authors:
    Pakuła M., Mały E., Uruski P., Witucka A., Bogucka M., Jaroszewska N., Makowska N., Niklas A., Moszyński R., Sajdak S., Tykarski A., Mikuła-Pietrasik J., Książek K.
    Academic press:
    Cancers (year: 2020, volume: 12, pages: 296), Publisher: MDPI
    Status:
    Published
    DOI:
    10.3390/cancers12020296 – link to the publication

  4. A unique pattern of mesothelial-mesenchymal transition induced in the normal peritoneal mesothelium by high-grade serous ovarian cancer

    Authors:
    Pakuła M, Uruski P, Niklas A., Woźniak A, Szpurek D., Tykarski A., Mikuła-Pietrasik J., Książek K.
    Academic press:
    Cancers (year: 2019, volume: 11, pages: 662), Publisher: MDPI
    Status:
    Published
    DOI:
    10.3390/cancers11050662 – link to the publication

  5. Where does cellular senescence belong in the pathophysiology of ovarian cancer?

    Authors:
    Ksiazek K.
    Academic press:
    Seminars in Cancer Biology (year: 2021, volume: ., pages: .), Publisher: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.semcancer.2020.11.021 – link to the publication

  6. Primary high-grade serous ovarian cancer cells are sensitive to senescence induced by carboplatin and paclitaxel in vitro

    Authors:
    Uruski P, Sepetowska A, Konieczna C, Pakuła M, Wyrwa M, Tussupkaliyev A, Tykarski A, Mikuła-Pietrasik J, Książek K.
    Academic press:
    Cell Mol Biology Letters (year: 2021, volume: 26, pages: 44), Publisher: BMC
    Status:
    Published
    DOI:
    10.1186/s11658-021-00287-4 – link to the publication

  7. Malignant Ascites Promote Adhesion of Ovarian Cancer Cells to Peritoneal Mesothelium and Fibroblasts

    Authors:
    Uruski P, Mikuła-Pietrasik J, Pakuła M, Budkiewicz S, Drzewiecki M, Gaiday AN, Wierzowiecka M, Naumowicz E, Moszyński R, Tykarski A, Książek K.
    Academic press:
    Int J Mol Sci (year: 2021, volume: 22, pages: 4222), Publisher: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms22084222. – link to the publication

  8. Patient-Specific Variables Determine the Extent of Cellular Senescence Biomarkers in Ovarian Tumors In Vivo

    Authors:
    Uruski P, Mikuła-Pietrasik J, Naumowicz E, Kaźmierczak K, Gaiday AN, Królak J, Nowakowski B, Moszyński R, Tykarski A, Książek K.
    Academic press:
    Biomedicines (year: 2021, volume: 9, pages: 330), Publisher: MDPI
    Status:
    Published
    DOI:
    10.3390/biomedicines9040330 – link to the publication

  9. Senescence-related deterioration of intercellular junctions in the peritoneal mesothelium promotes the transmesothelial invasion of ovarian cancer cells

    Authors:
    Pakuła M, Witucka A, Uruski P, Radziemski A, Moszyński R, Szpurek D, Maksin K, Woźniak A, Sajdak S, Tykarski A, Mikuła-Pietrasik J, Książek K.
    Academic press:
    Scientific Reports (year: 2019, volume: 20, pages: 7587), Publisher: Nature Publishing Group
    Status:
    Published
    DOI:
    10.1038/s41598-019-44123-4 – link to the publication

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