Projects funded by the NCN

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Keywords

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Evaluation of the influence of progressive noradrenergic neurodegeneration on dopaminergic system functioning in context of presymptomatic phase of Parkinson's disease.

2017/25/B/NZ7/02406

Keywords:

noradrenergic system dopaminergic system transgenic models Parkinson's disease

Descriptors:

  • NZ7_14: Pharmacy, pharmacotherapy, pharmacology
  • NZ4_9: Systems neurobiology
  • NZ5_3: Pathogenesis of human diseases

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Grzegorz Kreiner 

Number of co-investigators in the project: 5

Call: OPUS 13 - announced on 2017-03-15

Amount awarded: 1 620 000 PLN

Project start date (Y-m-d): 2018-01-03

Project end date (Y-m-d): 2023-07-02

Project duration:: 66 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Oprogramowanie do archiwizacji i dokumentacji przebiegu projektu (15 000 PLN)
  2. Laptop z podstawowym oprogramowaniem DTP.
  3. Elektroporator (41 200 PLN)
  4. Laptop z podstawowym oprogramowaniem DTP (10 000 PLN)
  5. Stolik stereotaktyczny z pompą infuzyjną.
  6. Wirówka z chłodzeniem (32 000 PLN)

Information in the final report

  • Publication in academic press/journals (4)
  • Articles in post-conference publications (11)
  1. Genetic lesions of the noradrenergic system trigger induction of oxidative stress and inflammation in the ventral midbrain
    Authors:
    Barut J, Rafa-Zabłocka K, Jurga AM, Bagińska M, Nalepa I, Parlato R, Kreiner G
    Academic press:
    Neurochemistry International (rok: 2022, tom: 155, strony: 45301), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.neuint.2022.105302 - link to the publication
  2. Stimulation of noradrenergic transmission by reboxetine is beneficial for a mouse model of progressive parkinsonism
    Authors:
    Kreiner G, Rafa-Zabłocka K, Barut J, Chmielarz P, Kot M, Bagińska M, Parlato R, Daniel WA, Nalepa I
    Academic press:
    Scientific Reports (rok: 2019, tom: 4,02916666666667, strony: 45300), Wydawca: Nature Publishing Group
    Status:
    Published
    DOI:
    10.3389/fnmol.2019.00106. - link to the publication
  3. What have we learned recently from transgenic mouse models about neurodegeneration? The most promising discoveries of this millennium
    Authors:
    Kreiner G
    Academic press:
    Pharmacol Rep (rok: 2018, tom: 70, strony: 1105-1115), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.pharep.2018.09.006 - link to the publication
  4. Integration of the deacetylase SIRT1 in the response to nucleolar stress: metabolic implications for neurodegenerative diseases
    Authors:
    Kreiner G, Sönmez A, Liss B, Parlato R
    Academic press:
    Front Mol Neurosci (rok: 2019, tom: vol. 12, strony: fnmol.2019.00106), Wydawca: Frontiers
    Status:
    Published
    DOI:
    10.3389/fnmol.2019.00106 - link to the publication
  1. Novel transgenic mice model to study presymptomatic phase of Parkinson's Disease: attempt of CRISPR/Cas9 exploitation for genetically evoked progressive degeneration of noradrenergic neurons
    Authors:
    Barut J, Rafa-Zabłocka K, Chmielarz P, Jurga A, Bagińska M, Parlato R, Domanskyi A, Nalepa I, Kreiner G
    Conference:
    Neuronus 2020 - IBRO Neuroscience Forum online (rok: 2020, ), Wydawca: Student's Neuroscience Society NEURONUS
    Data:
    konferencja 8-11.12
    Status:
    Published
  2. Phenotypic alterations observed in mice genetically depleted of Dbh-expressing cells in the locus coeruleus associated with the prodromal symptoms of Parkinson's disease
    Authors:
    Rafa-Zablocka K, Barut J, Kreiner G
    Conference:
    51st Annual Meeting of SfN - Neuroscience 2022 (rok: 2022, ), Wydawca: Society for Neuroscience
    Data:
    konferencja 12-16.11.2022
    Status:
    Published
  3. Transgenic mice with progressive degeneration of noradrenergic neurons restricted to locus coeruleus present depressive-like behavior and motor disturbances
    Authors:
    Rafa-Zablocka K, Barut J, Baginska M, Kreiner G
    Conference:
    35th ECNP Congress (rok: 2022, ), Wydawca: Elsevier
    Data:
    konferencja 15-18.10.2022
    Status:
    Published
  4. Utilization of conditional single lentivirus CRISPR/Cas9 vector for efficient gene knockout generation in adult neurons in vivo and in vitro
    Authors:
    Barut J, Rafa-Zabłocka K, Chmielarz P, Bagińska M, Domanskyi A, Kreiner G
    Conference:
    FENS Regional Meeting (rok: 2021, ), Wydawca: Polish Neuroscience Society
    Data:
    konferencja 25-27.08.2021
    Status:
    Published
  5. Mice with genetically evoked selective loss of noradrenergic system as a possible tool to study presymptomatic phase of Parkinson's disease
    Authors:
    Kreiner G, Rafa-Zablocka K, Jurga A, Barut J, Bagińska M, Parlato R, Nalepa I
    Conference:
    48th Annual Meeting of SfN - Neuroscience 2018 (rok: 2018, ), Wydawca: Society for Neuroscience
    Data:
    konferencja 3-7.11
    Status:
    Published
  6. Single, conditional, lentiviral CRISPR/Cas9 vectors for efficient mutagenesis in neurons – a possible new strategy for modeling prodromal Parkinson's disease
    Authors:
    Barut J, Rafa-Zabłocka K, Chmielarz P, Domanskyi A, Baginska M, Herian M, Gołembiowska K, Kreiner G
    Conference:
    35th ECNP Congress (rok: 2022, ), Wydawca: Elsevier
    Data:
    konferencja 15-18.10.2022
    Status:
    Published
  7. E!cient cell-type specific mutagenesis in adult neurons using single, conditional, lentiviral CRISPR/Cas9 vectors - new strategy to study early e"ects of noradrenergic cells degeneration in Parkinson's disease.
    Authors:
    Barut J, Rafa-Zabłocka K, Wilczkowski M, Baginska M, Domanskyi A, Herian M, Gołembiowska K, Kreiner G
    Conference:
    51st Annual Meeting of SfN - Neuroscience 2022 (rok: 2022, ), Wydawca: Society for Neuroscience
    Data:
    konferencja 12-16.11.2022
    Status:
    Published
  8. Effects of genetic impairment of the noradrenergic system on the expression of inflammatory markers in the SN/VTA neurons of mice.
    Authors:
    Rafa-Zabłocka K, Barut J, Bagińska M, Nalepa I, Kreiner G
    Conference:
    4th Central European Biomedical Congress (rok: 2021, ), Wydawca: CEBC Abstracts
    Data:
    konferencja 7-9.06.2021
    Status:
    Published
  9. Evaluation of the TIF-IA-deficient mouse model of slow progressive noradrenergic degeneration as a tool to study presymptomatic phase of Parkinson's disease
    Authors:
    Rafa-Zabłocka K, Barut J, Baginska M, Domanskyi A, Nalepa I, Kreiner G
    Conference:
    FENS 2020 Virtual Forum | International Neuroscience (rok: 2020, ), Wydawca: FENS
    Data:
    konferencja 11-15.07
    Status:
    Published
  10. Exploitation of in-vitro and in-vivo models characterized by enhancement of astrocytes upon noradrenergic targeting for study of presymptomatic Parkinson's disease
    Authors:
    Barut J, Rafa-Zabłocka K, Jurga A, Bagińska M, Nalepa I, Parlato R, Kreiner G
    Conference:
    34th ECNP Congress (rok: 2021, ), Wydawca: Elsevier
    Data:
    konferencja 2-5.10.2021
    Status:
    Published
  11. The influence of genetically induced loss of noradrenergic neurons on the proand anti-inflammatory markers in the SN/VTA neurons of mice.
    Authors:
    Rafa-Zabłocka K, Barut J, Bagińska M, Nalepa I, Kreiner G
    Conference:
    FENS Regional Meeting (rok: 2021, ), Wydawca: Polish Neuroscience Society
    Data:
    konferencja 25-27.08.2021
    Status:
    Published

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