Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

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Characterization of clozapine and risperidone mechnism of action at the cell nucleus level

2017/25/B/NZ4/01403

Keywords:

antipsychotic drugs clozapine risperidone nuclear proteins

Descriptors:

  • NZ2_3:
  • NZ5_7:
  • NZ4_9:

Panel:

NZ4 - Biology of tissues, organs and organisms: morphology and functions of animal's and human's systems, organs and organisms, experimental medicine, basics of neurology

Host institution :

Uniwersytet Jagielloński, Wydział Biochemii, Biofizyki i Biotechnologii

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Sylwia Kędracka-Krok 

Number of co-investigators in the project: 9

Call: OPUS 13 - announced on 2017-03-15

Amount awarded: 1 299 700 PLN

Project start date (Y-m-d): 2018-02-06

Project end date (Y-m-d): 2023-02-05

Project duration:: 60 months (the same as in the proposal)

Project status: Project settled

Project description

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Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (4)
  • Book publications / chapters in book publications (1)
  1. Contrasting Effects of Clozapine and Risperidone on Cholesterol Metabolism, Synaptic Proteins, and Transcriptional Regulation in Human LUHMES Neurons
    Authors:
    Piotr Rybczynski1,2,# Radosław Cacala1, Zuzanna Cepil1, Ewelina Fic1, Weronika Romanska1,2, Łukasz Marczak3, Katarzyna Pustelny1 and Sylwia Kedracka-Krok1#*
    Academic press:
    Molecular Neurobiology (rok: 2025, tom: 63, strony: 21), Wydawca: Spriner
    Status:
    Published
    DOI:
    10.1007/s12035-025-05515-y - link to the publication
  2. NT2-derived Astrocyte-Neuron Co-Culture Reflects Physiological Relevance and Offers Research Validity
    Authors:
    Sylwia Kedracka-Krok1*, Ewelina Fic1, Zuzanna Cepil1, Piotr Rybczyński1, Agata Szlaga2, Radosław Cacała1, Sławomir Lasota3, Anna Blasiak2, Marta Dziedzicka-Wasylewska1
    Academic press:
    Cellular & Molecular Biology Letters (rok: 2025, tom: 30, strony: 44), Wydawca: Springer Nature
    Status:
    Published
    DOI:
    10.1186/s11658-025-00765-z - link to the publication
  3. Clozapine's Molecular Signature: Selective 5-HT2A Receptor Downregulation and Signaling in Rat Brain Cortical Regions
    Authors:
    Sylwia Kedracka-Krok1, Jakub Nowak1,4, Ewelina Fic1, Joanna Solich2, Piotr Rybczynski1,3, Weronika Romanska1,3, Patrycja Sarga1, Katarzyna Pustelny1, Marta Dziedzicka-Wasylewska1
    Academic press:
    Journal of Neurochemistry (rok: 2025, tom: 169, strony: 24), Wydawca: Wiley
    Status:
    Published
    DOI:
    10.1111/jnc.70229 - link to the publication
  4. Proteome Analysis of PC12 Cells Reveals Alterations in Translation Regulation and Actin Signaling Induced by Clozapine
    Authors:
    Jankowska U, Skupien-Rabian B, Swiderska B, Prus G, Dziedzicka-Wasylewska M, Kedracka-Krok S.
    Academic press:
    Neurochemical Research (rok: 2021, tom: 8, strony: 2097-2111), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s11064-021-03348-4 - link to the publication
  1. Analysis of a nuclear intrinsically disordered proteome
    Authors:
    Bozena Skupien-Rabian, Urszula Jankowska and Sylwia Kedracka-Krok
    Book:
    Methods in Molecular Biology (rok: 2020, tom: 2175, strony: 181-196), Wydawca: Springer
    Status:
    Published

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