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Modulation of mutant huntingtin level by genistein in the mouse model of Huntington's disease and its effects on psychomotor development of animals

2017/25/N/NZ2/00812

Keywords:

Huntington's disease genistein autophagy animal behaviour in neurogenetic disorders

Descriptors:

  • NZ2_1: Molecular genetics
  • NZ4_7: Neurophysiology
  • NZ3_5: Molecular neurobiology

Panel:

NZ2 - Genetics, genomics: molecular genetics, genomics, proteomics, bioinformatics, systems biology, genetic epidemiology

Host institution :

Uniwersytet Gdański, Wydział Biologii

woj. pomorskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

Karolina Pierzynowska 

Number of co-investigators in the project: 3

Call: PRELUDIUM 13 - announced on 2017-03-15

Amount awarded: 180 000 PLN

Project start date (Y-m-d): 2018-01-24

Project end date (Y-m-d): 2023-01-23

Project duration:: 60 months (the same as in the proposal)

Project status: Project settled

Project description

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Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (7)
  1. Behavioral- and blood-based biomarkers for Huntington's disease: Studies on the R6/1 mouse model with prospects for early diagnosis and monitoring of the disease
    Authors:
    Podlacha M, Pierzynowska K, Gaffke L, Jerzemowska G, Piotrowska E, Węgrzyn G
    Academic press:
    Brain, Behavior & Immunity - Health (rok: 2022, tom: 23, strony: 100482), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.bbih.2022.100482 - link to the publication
  2. Genistein induces degradation of mutant huntingtin in fibroblasts from Huntington's disease patients
    Authors:
    Pierzynowska K., Gaffke L., Cyske Z., Węgrzyn G
    Academic press:
    Metabolic Brain Disease (rok: 2019, tom: 34, strony: 715-720), Wydawca: Springer-Nature
    Status:
    Published
    DOI:
    10.1007/s11011-019-00405-4 - link to the publication
  3. Molekularne mechanizmy działania genisteiny w świetle terapii chorób genetycznych i immunologicznych
    Authors:
    Pierzynowska K, Podlacha M, Brokowska J, Gaffke L, Mantej J, Cyske Z, Rintz E, Osiadły M, Bartkowski M, Puchalski M, Grabski M, Pierzynowski M, Pankanin D, Piotrowska E, Tukaj S, Wegrzyn G.
    Academic press:
    Postępy biochemii (rok: 2018, tom: 64, strony: 262-276), Wydawca: Polskie Towarzystwo Biochemiczne
    Status:
    Published
    DOI:
    10.18388/pb.2018_140 - link to the publication
  4. Correction of symptoms of Huntington's disease by genistein through the FOXO3-mediated autophagy 3 stimulation
    Authors:
    Pierzynowska K, Podlacha M, Gaffke L, Rintz E, Wiśniewska K, Cyske Z, Węgrzyn G
    Academic press:
    Nature Neuroscience (rok: 2023, tom: -, strony: -), Wydawca: Nature Publishing Group
    Status:
    Submitted
    DOI:
    brak - link to the publication
  5. Autophagy stimulation as a promising approach in treatment of neurodegenerative diseases
    Authors:
    Pierzynowska K, Gaffke L, Cyske Z, Puchalski M, Rintz E, Bartkowski M, Osiadły M, Pierzynowski M, Mantej J, Piotrowska E, Węgrzyn G.
    Academic press:
    Metabolic Brain Disease (rok: 2018, tom: 33, strony: 989-1008), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s11011-018-0214-6 - link to the publication
  6. Hair dysmorphology in the R6/1 and R6/2 mouse models of Huntington's disease
    Authors:
    Pierzynowska K, Podlacha M, Luszczek D, Rintz E, Gaffke L, Szczudło Z, Tomczyk M, Smolenski RT, Węgrzyn G
    Academic press:
    Gene (rok: 2021, tom: 765, strony: 145133), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.gene.2020.145133 - link to the publication
  7. Potencjał autofagii indukowanej przez genisteinę w leczeniu chorób neurodegeneracyjnych
    Authors:
    Pierzynowska K, Cyske Z, Gaffke Z, Rintz E, Mantej J, Podlacha M, Wiśniewska K, Żabińska M, Sochocka M, Lorenc P, Bielańska P, Giecewicz I, Węgrzyn G
    Academic press:
    Postępy Biochemii (rok: 2021, tom: 67, strony: 117-129), Wydawca: Polskie Towarzystwo Biochemiczne
    Status:
    Published
    DOI:
    10.18388/pb.2021_380 - link to the publication

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