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Functional, genetic and epigenetic aspects of DNA repair in Rheumatoid arthritis

2017/25/B/NZ6/01358

Keywords:

Rheumatoid arthritis DNA repair DNA damage

Descriptors:

  • NZ6_1: Adaptive and innate immunity
  • NZ2_1: Molecular genetics

Panel:

NZ6 - Human and animal immunology and infection: immunity, immune disorders, immunotherapy, infectious and invasive diseases, microbiology, transplantology, allergology

Host institution :

Uniwersytet Łódzki, Wydział Biologii i Ochrony Środowiska

woj. łódzkie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Tomasz Popławski 

Number of co-investigators in the project: 9

Call: OPUS 13 - announced on 2017-03-15

Amount awarded: 1 184 400 PLN

Project start date (Y-m-d): 2018-01-25

Project end date (Y-m-d): 2022-07-24

Project duration:: 54 months (the same as in the proposal)

Project status: Project settled

Project description

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Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (5)
  1. SNP in PTPN22, PADI4, and STAT4 but Not TRAF1 and CD40 Increase the Risk of Rheumatoid Arthritis in Polish Population
    Authors:
    Tomasz Budlewski, Joanna Sarnik, Grzegorz Galita, Grzegorz Dragan, Olga Brzezińska, Marta Popławska, Tomasz Popławski, Joanna Makowska
    Academic press:
    International Journal of Molecular Sciences (rok: 2023, tom: 24(8), strony: 7586), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms24087586 - link to the publication
  2. Increased Sensitivity of PBMCs Isolated from Patients with Rheumatoid Arthritis to DNA Damaging Agents Is Connected with Inefficient DNA Repair
    Authors:
    Grzegorz Galita, Olga Brzezianska, Izabela Gulbas, Joanna Sarnik, Marta Poplawska, Joanna Makowska, Tomasz Poplawski
    Academic press:
    Journal of Clinical Medicine (rok: 2020, tom: 9(4), strony: 988), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/jcm9040988 - link to the publication
  3. Polymorphisms in DNA Repair Genes and Association with Rheumatoid Arthritis in a Pilot Study on a Central European Population
    Authors:
    Grzegorz Galita, Joanna Sarnik, Olga Brzezinska, Tomasz Budlewski, Grzegorz Dragan, Marta Poplawska, Ireneusz Majsterek, Tomasz Poplawski, Joanna S Makowska
    Academic press:
    International Journal of Molecular Sciences (rok: 2023, tom: 24(4), strony: 3804), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms24043804 - link to the publication
  4. Machine Learning-Based Prediction of Rheumatoid Arthritis with Development of ACPA Autoantibodies in the Presence of Non-HLA Genes Polymorphisms
    Authors:
    Grzegorz Dudek, Sebastian Sakowski, Olga Brzezińska, Joanna Sarnik, Tomasz Budlewski, Grzegorz Dragan, Marta Poplawska, Tomasz Poplawski, Michal Bijak, Joanna Makowska
    Academic press:
    PLOS ONE , Wydawca: PLOS
    Status:
    Submitted
    DOI:
    brak - link to the publication
  5. The association between inefficient repair of oxidative DNA lesions and common polymorphisms of the key base excision repair genes as well as their expression levels in patients with Rheumatoid Arthritis
    Authors:
    Grzegorz Galita, Joanna Sarnik, Gabriela Zajac, Olga Brzezińska, Tomasz Budlewski, Marta Popławska, Karolina Przybylowska-Sygut, Joanna Makowska and Tomasz Popławski
    Academic press:
    Archives of Medical Science (rok: 2022, tom: -, strony: -), Wydawca: Termedia
    Status:
    Accepted for publication
    DOI:
    10.5114/aoms/163133 - link to the publication

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