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Molecular and pharmacological approaches based on inhibition of glycolysis to overcome de novo- and antiangiogenic therapy-induced resistance of GBM

2017/25/B/NZ3/00251

Keywords

Descriptors

  • NZ3_2: Fizjologia komórki
  • NZ3_5: Neurobiologia molekularna
  • NZ7_14: Farmacja, farmakoterapia, farmakologia

Panel

NZ3 – Cellular and developmental biology: cell biology, developmental biology, ageing biology, neurobiology

Host institution

Wojskowy Instytut Higieny i Epidemiologii im. gen. Karola Kaczkowskiego

Voivodeship: mazowieckie

Other projects carried out by the institution »

Principal investigator (from the host institution)

dr hab. Beata Teresa Pająk

Number of co-investigators in the project: 5

Call

OPUS 13 – announced on 2017-03-15

Amount awarded
1 254 900 PLN
Project start date
2018-02-09
Project end date
2022-10-08
Project duration
56 months (the same as in the proposal)
Project status
Project settled

Project description

Download the project description in a pdf file

Note — project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Chłodziarko-zamrażarka. Cost: 2 500 PLN
  2. Dewar z ciekłym azotem. Cost: 5 000 PLN
  3. Komora laminarna do hodowli komórkowych. Cost: 28 000 PLN
  4. Kołyska laboratoryjna do Western blot. Cost: 3 000 PLN
  5. Pipetor automatyczny do pipet serologicznych. Cost: 2 000 PLN
  6. Rozbudowa systemu do archiwizacji żeli o program do analizy obrazów HRP. Cost: 18 000 PLN

Information in the final report

Publication in academic press/journals (6)

  1. X-ray wavefunction refinement and comprehensive structural studies on bromo-substituted analogues of 2-deoxy-D-glucose in solid state and solution.

    Authors:
    M. Ziemniak, S. Pawlędzio, A. Zawadzka-Kazimierczuk, P. Dominiak, D. Trzybiński, W. Koźmiński, R. Zieliński, I. Fokt, W. Priebe, K. Woźniak, B. Pająk
    Academic press:
    RSC Advances (year: 2022, volume: 12, pages: 8345), Publisher: Royal Society of Chemistry
    Status:
    Published
    DOI:
    10.1039/d2ra90029g – link to the publication

  2. 2-Deoxy-d-Glucose and Its Analogs: From Diagnostic to Therapeutic Agents

    Authors:
    B. Pajak, E. Siwiak, M. Sołtyka, A. Priebe, R. Zielin ́ski, I. Fokt , M. Ziemniak, A. Jaskiewicz , R. Borowski, T. Domoradzki. and W. Priebe
    Academic press:
    International Journal of Molecular Sciences (year: 2020, volume: 21, pages: 234), Publisher: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms21010234 – link to the publication

  3. Experimental and Computational Studies on Structure and Energetic Properties of Halogen Derivatives of 2-Deoxy-D-Glucose

    Authors:
    Marcin Ziemniak, Anna Zawadzka-Kazimierczuk, Sylwia Pawledzio, Maura Malinska, Maja Sołtyka, Damian Trzybinski, Wiktor Koźminński, Stanisław Skora, Rafał Zieliński, Izabela Fokt, Waldemar Priebe, Krzysztof Woźniak, Beata Pająk
    Academic press:
    International Journal of Molecular Sciences (year: 2021, volume: 22, pages: 3720), Publisher: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms22073720 – link to the publication

  4. Synergistic Anticancer Effect of Glycolysis and Histone Deacetylases Inhibitors in a Glioblastoma Model

    Authors:
    Beata Pająk, Ewelina Siwiak-Niedbalska, Anna Jaskiewicz, Maja Sołtyka, Rafał Zieliński, Tomasz Domoradzki, Izabela Fokt, Stanisław Skóra, Waldemar Priebe
    Academic press:
    Biomedicines (year: 2021, volume: 9, pages: 1749), Publisher: MDPI
    Status:
    Published
    DOI:
    10.3390/biomedicines9121749 – link to the publication

  5. Looking for the Holy Grail—Drug Candidates for Glioblastoma Multiforme Chemotherapy

    Authors:
    Beata Pająk
    Academic press:
    Biomedicines (year: 2022, volume: 10, pages: 1001), Publisher: MDPI
    Status:
    Published

  6. WP1234 – a novel anticancer agent with bifunctional activity in a glioblastoma model

    Authors:
    B. Pająk, E. Siwiak-Niedbalska, A. Jaśkiewicz, M. Sołtyka. T. Domoradzki
    Academic press:
    Biomedicines (year: 2022, volume: 10, pages: 2799), Publisher: MDPI
    Status:
    Published
    DOI:
    10.3390/biomedicines10112799 – link to the publication

Articles in post-conference publications (1)

  1. New derivatives of 2-deoxy-D-glucose (2-DG) in the therapy of glioblastoma multiforme - preliminary studies

    Authors:
    E. Siwiak, M. Sołtyka, A. Jaśkiewicz, M. Ziemniak, W. Priebe, B. Pajak
    Conference:
    4th International Brain Research School (year: 2019, pages: 10), Publisher: Society of Cell Membranes and Free Oxygen Radicals
    Date:
    conference 44006
    Status:
    Published

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