Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

Delete all

Molecular and pharmacological approaches based on inhibition of glycolysis to overcome de novo- and antiangiogenic therapy-induced resistance of GBM

2017/25/B/NZ3/00251

Keywords:

glycolysis inhibitors 2-deoksy-D-glucose glioblastoma multiforme

Descriptors:

  • NZ3_2: Cell physiology
  • NZ3_5: Molecular neurobiology
  • NZ7_14: Pharmacy, pharmacotherapy, pharmacology

Panel:

NZ3 - Cellular and developmental biology: cell biology, developmental biology, ageing biology, neurobiology

Host institution :

Wojskowy Instytut Higieny i Epidemiologii im. gen. Karola Kaczkowskiego

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Beata Pająk 

Number of co-investigators in the project: 5

Call: OPUS 13 - announced on 2017-03-15

Amount awarded: 1 254 900 PLN

Project start date (Y-m-d): 2018-02-09

Project end date (Y-m-d): 2022-10-08

Project duration:: 56 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Pipetor automatyczny do pipet serologicznych (2 000 PLN)
  2. Rozbudowa systemu do archiwizacji żeli o program do analizy obrazów HRP (18 000 PLN)
  3. Komora laminarna do hodowli komórkowych (28 000 PLN)
  4. Kołyska laboratoryjna do Western blot (3 000 PLN)
  5. Chłodziarko-zamrażarka (2 500 PLN)
  6. Dewar z ciekłym azotem (5 000 PLN)

Information in the final report

  • Publication in academic press/journals (6)
  • Articles in post-conference publications (1)
  1. Experimental and Computational Studies on Structure and Energetic Properties of Halogen Derivatives of 2-Deoxy-D-Glucose
    Authors:
    Marcin Ziemniak, Anna Zawadzka-Kazimierczuk, Sylwia Pawledzio, Maura Malinska, Maja Sołtyka, Damian Trzybinski, Wiktor Koźminński, Stanisław Skora, Rafał Zieliński, Izabela Fokt, Waldemar Priebe, Krzysztof Woźniak, Beata Pająk
    Academic press:
    International Journal of Molecular Sciences (rok: 2021, tom: 22, strony: 3720), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms22073720 - link to the publication
  2. Synergistic Anticancer Effect of Glycolysis and Histone Deacetylases Inhibitors in a Glioblastoma Model
    Authors:
    Beata Pająk, Ewelina Siwiak-Niedbalska, Anna Jaskiewicz, Maja Sołtyka, Rafał Zieliński, Tomasz Domoradzki, Izabela Fokt, Stanisław Skóra, Waldemar Priebe
    Academic press:
    Biomedicines (rok: 2021, tom: 9, strony: 1749), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/biomedicines9121749 - link to the publication
  3. 2-Deoxy-d-Glucose and Its Analogs: From Diagnostic to Therapeutic Agents
    Authors:
    B. Pajak, E. Siwiak, M. Sołtyka, A. Priebe, R. Zielin ́ski, I. Fokt , M. Ziemniak, A. Jaskiewicz , R. Borowski, T. Domoradzki. and W. Priebe
    Academic press:
    International Journal of Molecular Sciences (rok: 2020, tom: 21, strony: 234), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms21010234 - link to the publication
  4. Looking for the Holy Grail—Drug Candidates for Glioblastoma Multiforme Chemotherapy
    Authors:
    Beata Pająk
    Academic press:
    Biomedicines (rok: 2022, tom: 10, strony: 1001), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ - link to the publication
  5. WP1234 – a novel anticancer agent with bifunctional activity in a glioblastoma model
    Authors:
    B. Pająk, E. Siwiak-Niedbalska, A. Jaśkiewicz, M. Sołtyka. T. Domoradzki
    Academic press:
    Biomedicines (rok: 2022, tom: 10, strony: 2799), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/biomedicines10112799 - link to the publication
  6. X-ray wavefunction refinement and comprehensive structural studies on bromo-substituted analogues of 2-deoxy-D-glucose in solid state and solution.
    Authors:
    M. Ziemniak, S. Pawlędzio, A. Zawadzka-Kazimierczuk, P. Dominiak, D. Trzybiński, W. Koźmiński, R. Zieliński, I. Fokt, W. Priebe, K. Woźniak, B. Pająk
    Academic press:
    RSC Advances (rok: 2022, tom: 12, strony: 8345), Wydawca: Royal Society of Chemistry
    Status:
    Published
    DOI:
    10.1039/d2ra90029g - link to the publication
  1. New derivatives of 2-deoxy-D-glucose (2-DG) in the therapy of glioblastoma multiforme - preliminary studies
    Authors:
    E. Siwiak, M. Sołtyka, A. Jaśkiewicz, M. Ziemniak, W. Priebe, B. Pajak
    Conference:
    4th International Brain Research School (rok: 2019, ), Wydawca: Society of Cell Membranes and Free Oxygen Radicals
    Data:
    konferencja 44006
    Status:
    Published

O Narodowym Centrum Nauki

Finansowanie nauki

Współpraca zagraniczna

Centrum prasowe

Deklaracja dostępności
Przetwarzanie danych osobowych
Polityka cookies

Partnerzy