Projektowanie i synteza narzędzi molekularnych do badań struktury i funkcji końca 5' mRNA (kapu) oraz badanie ich kompleksów z białkami metodą krystalografii rentgenowskiej
2017/24/T/NZ1/00345
Descriptors
- NZ1_3: Biofizyka
- NZ1_4: Biologia strukturalna
- ST5_16: Chemia biologiczna
Panel
NZ1 – Molecular biology, structural biology, biotechnology: molecular biology, structural biology, biotechnology
Host institution
Uniwersytet Warszawski, Wydział Fizyki
Voivodeship: mazowieckie
Principal investigator (from the host institution)
Number of co-investigators in the project: 2
Call
ETIUDA 5 – announced on 2016-12-15
- Amount awarded
- 97 784 PLN
- Project start date
- 2017-10-02
- Project end date
- 2018-10-01
- Project duration
- 12 months (the same as in the proposal)
- Project status
- Project settled
Project description
Download the project description in a pdf file
Note — project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.
Information in the final report
Publication in academic press/journals (3)
-
The identity and methylation status of the first transcribed nucleotide in eukaryotic mRNA 5 cap modulates protein expression in living cells
- Authors:
- Paweł J. Sikorski, Marcin Warmiński, Dorota Kubacka, Tomasz Ratajczak, Dominika Nowis, Joanna Kowalska, Jacek Jemielity
- Academic press:
- Nucleic Acids Research (year: 2020, volume: 48(4), pages: 1607-1626), Publisher: Oxford University Press
- Status:
- Published
- DOI:
- 10.1093/nar/gkaa032 – link to the publication
-
Kinetic analysis of IFIT1 and IFIT5 interactions with different native and engineered RNAs and its consequences for designing mRNA-based therapeutics
- Authors:
- Beata Miedziak, Anna Dobieżyńska, Zbigniew M. Darżynkiewicz, Julia Bartkowska, Joanna Miszkiewicz, Joanna Kowalska, Marcin Warmiński, Michał Tyras, Joanna Trylska, Jacek Jemielity, Edward Darzynkiewicz, Renata Grzela
- Academic press:
- RNA (year: 2020, volume: 26, pages: 58-68), Publisher: Cold Spring Harbor Laboratory Press
- Status:
- Published
- DOI:
- 10.1261/rna.073304.119 – link to the publication
-
5′-Phosphorothiolate Dinucleotide Cap Analogues: Reagents for Messenger RNA Modification and Potent Small-Molecular Inhibitors of Decapping Enzymes
- Authors:
- Blazej A. Wojtczak, Pawel J. Sikorski, Kaja Fac-Dabrowska, Anna Nowicka, Marcin Warminski, Dorota Kubacka, Elzbieta Nowak, Marcin Nowotny, Joanna Kowalska, Jacek Jemielity
- Academic press:
- Journal of the American Chemical Society (year: 2018, volume: 140(18), pages: 5987-5999), Publisher: American Chemical Society
- Status:
- Published
- DOI:
- 10.1021/jacs.8b02597 – link to the publication