Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

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Projektowanie i synteza narzędzi molekularnych do badań struktury i funkcji końca 5' mRNA (kapu) oraz badanie ich kompleksów z białkami metodą krystalografii rentgenowskiej

2017/24/T/NZ1/00345

Keywords:

Descriptors:

  • NZ1_3: Biophysics
  • NZ1_4: Structural biology
  • ST5_16:

Panel:

NZ1 - Molecular biology, structural biology, biotechnology: molecular biology, structural biology, biotechnology

Host institution :

Uniwersytet Warszawski, Wydział Fizyki

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

Marcin Warmiński 

Number of co-investigators in the project: 2

Call: ETIUDA 5 - announced on 2016-12-15

Amount awarded: 97 784 PLN

Project start date (Y-m-d): 2017-10-02

Project end date (Y-m-d): 2018-10-01

Project duration:: 12 months (the same as in the proposal)

Project status: Project settled

Project description

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Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (3)
  • Book publications / chapters in book publications (1)
  1. The identity and methylation status of the first transcribed nucleotide in eukaryotic mRNA 5 cap modulates protein expression in living cells
    Authors:
    Paweł J. Sikorski, Marcin Warmiński, Dorota Kubacka, Tomasz Ratajczak, Dominika Nowis, Joanna Kowalska, Jacek Jemielity
    Academic press:
    Nucleic Acids Research (rok: 2020, tom: 48(4), strony: 1607-1626), Wydawca: Oxford University Press
    Status:
    Published
    DOI:
    10.1093/nar/gkaa032 - link to the publication
  2. 5′-Phosphorothiolate Dinucleotide Cap Analogues: Reagents for Messenger RNA Modification and Potent Small-Molecular Inhibitors of Decapping Enzymes
    Authors:
    Blazej A. Wojtczak, Pawel J. Sikorski, Kaja Fac-Dabrowska, Anna Nowicka, Marcin Warminski, Dorota Kubacka, Elzbieta Nowak, Marcin Nowotny, Joanna Kowalska, Jacek Jemielity
    Academic press:
    Journal of the American Chemical Society (rok: 2018, tom: 140(18), strony: 5987-5999), Wydawca: American Chemical Society
    Status:
    Published
    DOI:
    10.1021/jacs.8b02597 - link to the publication
  3. Kinetic analysis of IFIT1 and IFIT5 interactions with different native and engineered RNAs and its consequences for designing mRNA-based therapeutics
    Authors:
    Beata Miedziak, Anna Dobieżyńska, Zbigniew M. Darżynkiewicz, Julia Bartkowska, Joanna Miszkiewicz, Joanna Kowalska, Marcin Warmiński, Michał Tyras, Joanna Trylska, Jacek Jemielity, Edward Darzynkiewicz, Renata Grzela
    Academic press:
    RNA (rok: 2020, tom: 26, strony: 58-68), Wydawca: Cold Spring Harbor Laboratory Press
    Status:
    Published
    DOI:
    10.1261/rna.073304.119 - link to the publication
  1. Solid-Phase Synthesis of RNA 5'-Azides and Their Application for Labeling, Ligation and Cyclization via Click Chemistry
    Authors:
    Marcin Warmiński, Joanna Kowalska, Jacek Jemielity
    Book:
    Current Protocols in Nucleic Acid Chemistry , Wydawca: John Wiley & Sons
    Status:
    Submitted

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