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Mechanism of alternative splicing regulation by MBNL proteins

2017/24/C/NZ1/00112

Keywords:

alternative splicing MBNL protein:RNA interaction,

Descriptors:

  • NZ1_1: Molecular biology
  • NZ1_2: Biochemistry
  • NZ2_2: Genomics, transcriptomics, epigenomics

Panel:

NZ1 - Molecular biology, structural biology, biotechnology: molecular biology, structural biology, biotechnology

Host institution :

Uniwersytet im. Adama Mickiewicza w Poznaniu, Wydział Biologii

woj. wielkopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Katarzyna Taylor 

Number of co-investigators in the project: 1

Call: SONATINA 1 - announced on 2016-12-15

Amount awarded: 996 346 PLN

Project start date (Y-m-d): 2017-10-16

Project end date (Y-m-d): 2020-10-15

Project duration:: 36 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (5)
  1. Intrinsic regulatory role of RNA structural arrangement in alternative splicing control
    Authors:
    Taylor K., Sobczak K.
    Academic press:
    International Journal of Molecular Sciences (rok: 2020, tom: 21, strony: 0), Wydawca: Multidisciplinary Digital Publishing Institute
    Status:
    Published
    DOI:
    10.3390/ijms21145161 - link to the publication
  2. MBNL splicing activity depends on RNA binding site structural context
    Authors:
    Taylor K, Sznajder LJ, Cywoniuk P, Thomas JD, Swanson MS, Sobczak K.
    Academic press:
    Nucleic Acids Reseach (rok: 2018, tom: 46, strony: 9119-9133), Wydawca: Oxford University Press
    Status:
    Published
    DOI:
    10.1093/nar/gky565 - link to the publication
  3. Global Increase in Circular RNA Levels in Myotonic Dystrophy
    Authors:
    Karol Czubak, Katarzyna Taylor, Agnieszka Piasecka, Krzysztof Sobczak, Katarzyna Kozlowska, Anna Philips, Saam Sedehizadeh, J. David Brook, Marzena Wojciechowska and Piotr Kozlowski
    Academic press:
    Frontiers in Genetics (rok: 2019, tom: 10, strony: article 649), Wydawca: Frontiers
    Status:
    Published
    DOI:
    10.3389/fgene.2019.00649 - link to the publication
  4. Muscleblind-like 2 controls the hypoxia response of cancer cells
    Authors:
    Fischer S., Liddo A.D., Taylor K., Gerhardus A.S., Sobczak K., Zarnack K., Weigand J.E.
    Academic press:
    RNA (rok: 2020, ), Wydawca: Cold Spring Harbor Laboratory Press
    Status:
    Published
    DOI:
    10.1261/rna.073353.119 - link to the publication
  5. Loss of MBNL1 induces RNA mis-processing in the thymus and peripheral blood
    Authors:
    Sznajder J.L., Scotti M.M., Jihae Shin J., Taylor K., Ivankovic F., Nutter C.A., Aslam F.N., Subramony S.H., Ranum L.P., Swanson M.S.
    Academic press:
    Nature Communication (rok: 2020, tom: 11, strony: 0), Wydawca: Nature Research
    Status:
    Published
    DOI:
    10.1038/s41467-020-15962-x - link to the publication

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