Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

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Optimization of supramolecular helicates size in terms of interaction with DNA and antitumor activity

2017/24/C/ST5/00181

Keywords:

helicate silver(I) copper(I) DNA anticancer activity

Descriptors:

  • ST5_12: Methods of nanomaterials/materials synthesis
  • ST5_14: Other related subjects
  • ST5_16:

Panel:

ST5 - Materials: materials synthesis, structure-properties relations, advanced and functional materials with designed properties, (macro)molecular architecture, material engineering

Host institution :

Uniwersytet im. Adama Mickiewicza w Poznaniu, Wydział Chemii

woj. wielkopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Marta Fik 

Number of co-investigators in the project: 3

Call: SONATINA 1 - announced on 2016-12-15

Amount awarded: 497 853 PLN

Project start date (Y-m-d): 2017-11-03

Project end date (Y-m-d): 2020-03-02

Project duration:: 28 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (9)
  1. Synthesis and Spectroscopic Investigation of a Hexaaza Lanthanum(III) Macrocycle with a Hybrid-Type G4 DNA Stabilizing Effect
    Authors:
    Marta A. Fik-Jaskółka, Izabela Pospieszna-Markiewicz, Giovanni N. Roviello, Maciej Kubicki, Wanda Radecka-Paryzek, Violetta Patroniak
    Academic press:
    Inorganic Chemistry (rok: 2021, tom: 60, strony: 2122-2126), Wydawca: American Chemical Society
    Status:
    Published
    DOI:
    10.1021/acs.inorgchem.0c03260 - link to the publication
  2. Anthracene-thymine luminophores: Synthesis, photophysical properties, and imaging in living HeLa cells
    Authors:
    Artur Jabłoński, Aleksandra Kowalczyk, Marta A. Fik, Damian Trzybiński, Krzysztof Woźniak, Katerina Vinogradova, Sława Glińska, Valerije Vrček, Rafał Czerwieniec, Konrad Kowalski
    Academic press:
    Dyes and Pigments (rok: 2019, tom: 170, strony: 107554), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.dyepig.2019.107554 - link to the publication
  3. Co(II/III) Complexes with Benzoxazole and Benzothiazole Ligands as Efficient Heterogenous Photocatalysts for Organic Dyes Degradation
    Authors:
    Martyna Szymańska, Włodzimierz Czepa, Cezary Hołubowicz, Renata Świsłocka, Teresa Łuczak, Maciej Kubicki, Joanna Karpińska, Marta A. Fik-Jaskółka, Violetta Patroniak
    Academic press:
    Catalysts (rok: 2019, tom: 9, strony: 913), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/catal9110913 - link to the publication
  4. Dynamic Helicates Self-Assembly from Homo and Heterotopic Dynamic Covalent Ligand Strands
    Authors:
    Antonio Santoro, Jan Holub, Marta Fik-Jaskółka, Ghislaine Vantomme, Jean-Marie Lehn
    Academic press:
    Chemistry - A European Journal (rok: 2020, tom: 26, strony: 15664-15671), Wydawca: Wiley-VCH GmbH
    Status:
    Published
    DOI:
    10.1002/chem.202003496 - link to the publication
  5. Luminescent pyrenyl-GNA nucleosides: synthesis, photophysics and confocal microscopy studies in cancer HeLa cells
    Authors:
    Joanna Skiba, Aleksandra Kowalczyk, Marta A. Fik, Magdalena Gapińska, Damian Trzybiński, Krzysztof Woźniak, Valerije Vrček, Rafał Czerwieniec, Konrad Kowalski
    Academic press:
    Photochemical & Photobiological Sciences (rok: 2019, tom: 18, strony: 2449-2460), Wydawca: Royal Society of Chemistry
    Status:
    Published
    DOI:
    10.1039/c9pp00271e - link to the publication
  6. Thiophene-benzothiazole dyad ligand and its Ag(I) complex – Synthesis, characterization, interactions with DNA and BSA
    Authors:
    Martyna Szymańska, Małgorzata Insińska-Rak, Grzegorz Dutkiewicz, Giovanni N. Roviello, Marta A. Fik-Jaskółka, Violetta Patroniak
    Academic press:
    Journal of Molecular Liquids (rok: 2020, tom: 319, strony: 114182), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.molliq.2020.114182 - link to the publication
  7. New Artificial Biomimetic Enzyme Analogues Based on Iron(II/III) Schiff Base Complexes: An Effect of (Benz)imidazole Organic Moieties on Phenoxazinone Synthase and DNA Recognition
    Authors:
    Aleksandra Bocian, Martyna Szymańska, Daria Brykczyńska, Maciej Kubicki, Monika Wałęsa-Chorab, Giovanni N. Roviello, Marta A. Fik-Jaskółka, Adam Gorczyński, Violetta Patroniak
    Academic press:
    Molecules (rok: 2019, tom: 24, strony: 3173), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/molecules24173173 - link to the publication
  8. Biological macromolecule binding and anticancer activity of synthetic alkyne-containing L-phenylalanine derivatives
    Authors:
    Marta A. Fik-Jaskółka, Anna F. Mkrtchyan, Ashot S. Saghyan, Rosanna Palumbo, Agnieszka Belter, Liana A. Hayriyan, Hayarpi Simonyan, Valentina Roviello, Giovanni N. Roviello
    Academic press:
    Amino Acids (rok: 2020, tom: 52, strony: 755-769), Wydawca: Springer
    Status:
    Accepted for publication
    DOI:
    10.1007/s00726-020-02849-w - link to the publication
  9. Spectroscopic and SEM evidences for G4-DNA binding by a synthetic alkyne-containing amino acid with anticancer activity
    Authors:
    Marta A. Fik-Jaskółka, Anna F. Mkrtchyan, Ashot S. Saghyan, Rosanna Palumbo, Agnieszka Belter, Liana A. Hayriyan, Hayarpi Simonyan, Valentina Roviello, Giovanni N. Roviello
    Academic press:
    Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy (rok: 2020, tom: 229, strony: 117884), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.saa.2019.117884 - link to the publication

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