Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

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Endothelial inflammation studied in situ within functional blood vessels using Raman imaging, atomic force microscopy and imaged cytometry

2017/24/C/ST4/00075

Keywords:

Raman spectroscopy atomic force microscopy Raman fiber probes endothelium isolated functional blood vessels inflammation

Descriptors:

  • ST4_3: Molecular architecture and structure
  • ST4_13: Solid-state chemistry, surface physicochemistry
  • NZ7_14: Pharmacy, pharmacotherapy, pharmacology

Panel:

ST4 - Chemistry: physical chemistry/chemical physics, theoretical chemistry, analytical chemistry, inorganic chemistry, organic chemistry, method development

Host institution :

Uniwersytet Jagielloński, Jagiellońskie Centrum Rozwoju Leków (JCET)

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Marta Pacia 

Number of co-investigators in the project: 3

Call: SONATINA 1 - announced on 2016-12-15

Amount awarded: 688 346 PLN

Project start date (Y-m-d): 2017-12-22

Project end date (Y-m-d): 2022-10-21

Project duration:: 58 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (6)
  • Book publications / chapters in book publications (1)
  1. Combined Raman- and AFM-based detection of biochemical and nanomechanical features of endothelial dysfunction in aorta isolated from ApoE/LDLR−/− mice
    Authors:
    Martina Maase, Anna Rygula, Marta Z. Pacia, Bartosz Proniewski, Lukasz Mateuszuk, Magdalena Sternak, Agnieszka Kaczor, Stefan Chlopicki, Kristina Kusche-Vihrog
    Academic press:
    Nanomedicine: Nanotechnology, Biology, and Medicine (rok: 2019, tom: 16, strony: 97-105), Wydawca: Elselvier
    Status:
    Published
    DOI:
    10.1016/j.nano.2018.11.014 - link to the publication
  2. Rapid shear stress‑dependent ENaC membrane insertion is mediated by the endothelial glycocalyx and the mineralocorticoid receptor
    Authors:
    Zülfü C. Cosgun,Magdalena Sternak, Benedikt Fels, Anna Bar, Grzegorz Kwiatkowski, Marta Z. Pacia, Lisbeth Herrnböck, Martina Lindemann, Johannes Stegbauer, Sascha Höges, Stefan Chlopicki, Kristina Kusche-Vihrog
    Academic press:
    Cellular and Molecular Life Sciences (rok: 2022, tom: 79, strony: 45305), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s00018-022-04260-y - link to the publication
  3. Heterogeneity of chemical composition of lipid droplets in endothelial inflammation and apoptosis
    Authors:
    Marta Z. Pacia, Magdalena Sternak, Lukasz Mateuszuk, Marta Stojak, Agnieszka Kaczor, Stefan Chlopicki
    Academic press:
    Biochimica et Biophysica Acta (BBA) - Molecular Cell Research (rok: 2020, tom: 1867, strony: 45302), Wydawca: Elselvier
    Status:
    Published
    DOI:
    10.1016/j.bbamcr.2020.118681 - link to the publication
  4. Estimation of the content of lipids composing endothelial lipid droplets based on Raman imaging
    Authors:
    Marta Z. Pacia, Katarzyna Majzner, Krzysztof Czamara, Magdalena Sternak, Stefan Chlopicki, Malgorzata Baranska
    Academic press:
    Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids (rok: 2020, tom: 1865, strony: 45301), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.bbalip.2020.158758 - link to the publication
  5. Lipid Droplets Formation Represents an Integral Component of Endothelial Inflammation Induced by LPS
    Authors:
    Krzysztof Czamara, Marta Stojak, Marta Z. Pacia, Alicja Zieba, Malgorzata Baranska, Stefan Chlopicki, Agnieszka Kaczor
    Academic press:
    Cells (rok: 2021, tom: 10, strony: 45306), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/cells10061403 - link to the publication
  6. Rac1 regulates lipid droplets formation, nanomechanical, and nanostructural changes induced by TNF in vascular endothelium in the isolated murine aorta
    Authors:
    Marta Z. Pacia (corresponding author), Natalia Chorazy, Magdalena Sternak, Benedikt Fels, Michal Pacia, Mariusz Kepczynski, Kristina Kusche-Vihrog, Stefan Chlopicki
    Academic press:
    Cellular and Molecular Life Sciences (rok: 2022, tom: 79, strony: 45304), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s00018-022-04362-7 - link to the publication
  1. Vibrational imaging of proteins: changes in the tissues and cells in the lifestyle disease studies
    Authors:
    Katarzyna Majzner, Krzysztof Czamara, Marta Z. Pacia, Jakub Dybas, Ewelina Bik, Karolina Chrabaszcz, Ewelina Wiercigroch, Adrianna Dorosz, Adrinna Wislocka, Katarzyna M. Marzec, Kamilla Malek, Malgorzata Baranska
    Book:
    Vibrational spectroscopy in protein research (rok: 2020, tom: brak, strony: 177-218), Wydawca: Elsevier
    Status:
    Published

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