Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Changes in Candida albicans drug resistance and virulence in responce to different carbon sources

2016/23/B/NZ1/01928

Keywords:

Candida albicans ABC transporters ergosterol multidrug resistance

Descriptors:

  • NZ1_10: Microbiology
  • NZ1_3: Biophysics
  • NZ1_11: Other related subjects

Panel:

NZ1 - Molecular biology, structural biology, biotechnology: molecular biology, structural biology, biotechnology

Host institution :

Uniwersytet Wrocławski, Wydział Biotechnologii

woj. dolnośląskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Anna Krasowska 

Number of co-investigators in the project: 6

Call: OPUS 12 - announced on 2016-09-15

Amount awarded: 1 059 200 PLN

Project start date (Y-m-d): 2017-07-12

Project end date (Y-m-d): 2021-07-11

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Tensjometr.
  2. Ultrawirówka (170 000 PLN)

Information in the final report

  • Publication in academic press/journals (7)
  1. Fluconazole and Lipopeptide Surfactin Interplay During Candida albicans Plasma Membrane and Cell Wall Remodeling Increases Fungal Immune System Exposure
    Authors:
    Jakub Suchodolski, Daria Derkacz, Jakub Muraszko, Jarosław J. Panek , Aneta Jezierska , Marcin Łukaszewicz and Anna Krasowska
    Academic press:
    Pharmaceutics (rok: 2020, tom: 12, strony: 314-336), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/pharmaceutics12040314 - link to the publication
  2. Fructose induces fluconazole resistance in Candida albicans through activation of Mdr1 and Cdr1 transporters
    Authors:
    Suchodolski J. and Krasowska A.
    Academic press:
    International Journal of Molecular Sciences (rok: 2021, tom: 22, strony: 2127-2136), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms22042127 - link to the publication
  3. Lipid composition and cell surface hydrophobicity of Candida albicans influence the efficacy of fluconazole-gentamicin treatment
    Authors:
    Suchodolski J., Muraszko J., Korba A., Bernat P., Krasowska A.
    Academic press:
    Yeast (rok: 2020, tom: 37, strony: 117-129), Wydawca: Wiley
    Status:
    Published
    DOI:
    10.1002/yea.3455 - link to the publication
  4. Plasma membrane potential of Candida albicans measured by di-4-ANEPPS fluorescence depends on growth phase and regulatory factors
    Authors:
    Suchodolski J. and Krasowska A.
    Academic press:
    Microorganisms (rok: 2019, tom: 7, strony: 110-137), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/microorganisms7040110 - link to the publication
  5. Capric acid secreted by Saccharomyces boulardii influences the susceptibility of Candida albicans to fluconazole and amphotericin B
    Authors:
    Suchodolski J., Derkacz D., Bernat P., Krasowska A.
    Academic press:
    Scientific Report (rok: 2021, tom: 11, strony: 6519-6527), Wydawca: Springer Nature Research
    Status:
    Published
    DOI:
    10.1038/s41598-021-86012-9 - link to the publication
  6. Crucial role of ergosterol in plasma membrane composition, localisation and activity of Cdr1p and H+-ATPase in Candida albicans
    Authors:
    Suchodolski J., Muraszko J., Bernat P., Krasowska A.
    Academic press:
    Microorganisms (rok: 2019, tom: 22, strony: 378-413), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/microorganisms7100378 - link to the publication
  7. Lactate like fluconazole reduces ergosterol content in plasma membrane and synergically kills Candida albicans
    Authors:
    Suchodolski J., Muraszko J., Bernat P. and Krasowska A.
    Academic press:
    International Journal of Molecular Sciences (rok: 2021, tom: 22, strony: 5219-5228), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms22105219 - link to the publication

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