Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

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Factors influencing effective transport of anticancer drugs through cell membranes studied on the example of the interactions of anthracyclines with biomimetic systems mimicking biological membranes of healthy and cancer cells.

2016/23/D/ST4/03200

Keywords:

model phospholipid membranes doxorubicin Langmuir technique

Descriptors:

  • ST4_5: Analytical chemistry
  • ST4_13: Solid-state chemistry, surface physicochemistry

Panel:

ST4 - Chemistry: physical chemistry/chemical physics, theoretical chemistry, analytical chemistry, inorganic chemistry, organic chemistry, method development

Host institution :

Uniwersytet Warszawski, Wydział Chemii

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Dorota Matyszewska 

Number of co-investigators in the project: 3

Call: SONATA 12 - announced on 2016-09-15

Amount awarded: 399 800 PLN

Project start date (Y-m-d): 2017-07-18

Project end date (Y-m-d): 2021-01-17

Project duration:: 42 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. pompa perystaltyczna (5 000 PLN)
  2. zestaw komputerowy z drukarką wielofunkcyjną (6 000 PLN)
  3. myjka ultradźwiękowa (2 000 PLN)
  4. oscyloskop.
  5. jednostka sterująca i zbierająca.
  6. wanna Langmuira z komputerem.
  7. pH-metr (4 000 PLN)
  8. potencjostat z komputerem (60 000 PLN)
  9. zestaw miszadeł magnetycznych (3 000 PLN)

Information in the final report

  • Publication in academic press/journals (4)
  1. Interactions of anticancer drugs doxorubicin and idarubicin with lipid monolayers: New insight into the composition, structure and morphology
    Authors:
    Dorota Matyszewska, Ewa Nazaruk, Richard A. Campbell
    Academic press:
    Journal of Colloid and Interface Science (rok: 2021, tom: 581, strony: 403-416), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.jcis.2020.07.092 - link to the publication
  2. The influence of charge and lipophilicity of daunorubicin and idarubicin on their penetration of model biological membranes – Langmuir monolayer and electrochemical studies
    Authors:
    Dorota Matyszewska
    Academic press:
    BBA - Biomembranes (rok: 2019, tom: 1862, strony: 183104), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.bbamem.2019.183104 - link to the publication
  3. Effect of pH on the interactions of doxorubicin with charged lipid monolayers containing 1,2-dimyristoyl-sn-glycero-3-phospho-L-serine - An important component of cancer cell membranes
    Authors:
    Dorota Matyszewska, Sandra Moczulska
    Academic press:
    Electrochimica Acta (rok: 2018, tom: 280, strony: 229-237), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.electacta.2018.05.119 - link to the publication
  4. The effect of acyl chain length and saturation on the interactions of pirarubicin with phosphatidylethanolamines in 2D model urothelial cancer cell membranes
    Authors:
    Dorota Matyszewska, Angelika Jocek
    Academic press:
    Journal of Molecular Liquids (rok: 2021, tom: 323, strony: 114633), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.molliq.2020.114633 - link to the publication

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