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Long non-coding RNA signature and function in autoimmune demyelination

2016/23/B/NZ6/02541

Keywords

Descriptors

  • NZ6_1: Odporność swoista i nieswoista
  • NZ6_2: Immunologia kliniczna
  • NZ6_8: Inne zagadnienia pokrewne

Panel

NZ6 – Human and animal immunology and infection: immunity, immune disorders, immunotherapy, infectious and invasive diseases, microbiology, transplantology, allergology

Host institution

Uniwersytet Warmińsko-Mazurski w Olsztynie, Wydział Lekarski

Voivodeship: warmińsko-mazurskie

Other projects carried out by the institution »

Principal investigator (from the host institution)

prof. Marcin Przemysław Mycko

Number of co-investigators in the project: 7

Call

OPUS 12 – announced on 2016-09-15

Amount awarded
1 596 600 PLN
Project start date
2017-08-29
Project end date
2023-10-28
Project duration
74 months (the same as in the proposal)
Project status
Project settled

Project description

Download the project description in a pdf file

Note — project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

Publication in academic press/journals (9)

  1. microRNA and exosome profiling in multiple sclerosis

    Authors:
    Mycko MP; Baranzini SE
    Academic press:
    MULTIPLE SCLEROSIS JOURNAL (year: 2020, volume: 26, pages: 599-603), Publisher: SAGE PUBLICATIONS LTD, 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
    Status:
    Published
    DOI:
    10.1177/1352458519879303 – link to the publication

  2. Linking Mechanisms of Vitamin D Signaling with Multiple Sclerosis.

    Authors:
    Carlberg C, Mycko MP.
    Academic press:
    Cells (year: 2023, volume: 12, pages: 2391), Publisher: MDPI Open Access Journals
    Status:
    Published
    DOI:
    10.3390/cells12192391 – link to the publication

  3. Circular RNAs as a novel layer of regulatory mechanism in multiple sclerosis.

    Authors:
    Zurawska A, Mycko MP, Selmaj KW
    Academic press:
    J Neuroimmunol. (year: 2019, volume: 334, pages: 46030), Publisher: ELSEVIER, RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
    Status:
    Published
    DOI:
    10.1016/j.jneuroim.2019.576971 – link to the publication

  4. The Heat Shock Protein HSP70 Promotes Th17 Genes' Expression via Specific Regulation of microRNA

    Authors:
    Cwiklinska H, Cichalewska-Studzinska M, Selmaj KW, Mycko MP.
    Academic press:
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (year: 2020, volume: 21, pages: 2823), Publisher: MDPI, ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
    Status:
    Published
    DOI:
    10.3390/ijms21082823 – link to the publication

  5. Reconsidering the route of drug delivery in refractory multiple sclerosis: Toward a more effective drug accumulation in the central nervous system

    Authors:
    Kalkowski L, Walczak P, Mycko MP, Malysz-Cymborska I
    Academic press:
    Medical Research Review (year: 2023, volume: 43, pages: 2237-2259), Publisher: Wiley
    Status:
    Published
    DOI:
    10.1002/med.21973 – link to the publication

  6. Fluid phase biomarkers in multiple sclerosis

    Authors:
    Krzysztof W Selmaj, Marcin P Mycko, Roberto Furlan, Konrad Rejdak
    Academic press:
    Curr Opin Neurol (year: 2022, volume: 35, pages: 286-292), Publisher: Wolters Kluwer
    Status:
    Published
    DOI:
    10.1097/WCO.0000000000001058 – link to the publication

  7. Impact of Diminished Expression of circRNA on Multiple Sclerosis Pathomechanisms

    Authors:
    Marcin P Mycko, Anna E Zurawska, Igor Selmaj, Krzysztof W Selmaj
    Academic press:
    Front Immunol (year: 2022, volume: 13, pages: 875994), Publisher: Frontiers
    Status:
    Published
    DOI:
    10.3389/fimmu.2022.875994 – link to the publication

  8. Multiple Sclerosis: circRNA Profile Defined Reveals Links to B-Cell Function

    Authors:
    Anna E Zurawska, Marcin P Mycko, Igor Selmaj, Cedric S Raine , Krzysztof W Selmaj
    Academic press:
    Neurology Neuroimmunology Neuroinflammation (year: 2021, volume: 8(5), pages: e1041), Publisher: Wolters Kluwer
    Status:
    Published
    DOI:
    10.1212/NXI.0000000000001041 – link to the publication

  9. Exosomal profiling should be used to monitor disease activity in MS patients: Yes

    Authors:
    Mycko MP
    Academic press:
    Multiple Sclerosis Journal (year: 2023, volume: 10, pages: 1204– 1205), Publisher: SAGE PUBLICATIONS LTD, 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
    Status:
    Published
    DOI:
    10.1177/13524585231195860 – link to the publication

Articles in post-conference publications (3)

  1. Non-coding circular RNA genomowide profiling in MS reveals a pathogenic circuit disrupting B cells

    Authors:
    M.P. Mycko, A. Zurawska, I. Selmaj, K. Selmaj
    Conference:
    38th Congress of the European-Committee-for-Treatment-and-Research-in-Multiple-Sclerosis (year: 2022, pages: 716), Publisher: SAGE
    Date:
    conference OCT 26-28
    Status:
    Published

  2. Genome-wide transcriptome analysis of MS exosomes

    Authors:
    M. Mycko, L. Paukszto, J.P. Jastrzebski, K. Selmaj
    Conference:
    Conference: 35th Congress of the European-Committee-for-Treatment-and-Research-in-Multiple-Sclerosis (ECTRIMS) / 24th Annual Conference of Rehabilitation in MS Location: Stockholm, SWEDEN (year: 2019, pages: 283-284), Publisher: SAGE PUBLICATIONS LTD, 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
    Date:
    conference SEP 11-13, 2019
    Status:
    Published

  3. Circular RNA expression profiling indicates proinflammatory mechanisms in relapsing-remitting MS

    Authors:
    Mycko M; Zurawska A; Selmaj K
    Conference:
    5th Congress of the European-Academy-of-Neurology (EAN) (year: 2019, pages: 679), Publisher: WILEY, 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
    Date:
    conference JUN 29-JUL 02, 2019
    Status:
    Published

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