Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

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Long non-coding RNA signature and function in autoimmune demyelination

2016/23/B/NZ6/02541

Keywords:

autoimmune demyelination lncRNA Th cells multiple sclerosis experimental autoimmune encephalomyelitis single cell transcriptome analysis

Descriptors:

  • NZ6_1:
  • NZ6_2:
  • NZ6_8:

Panel:

NZ6 - Human and animal immunology and infection: immunity, immune disorders, immunotherapy, infectious and invasive diseases, microbiology, transplantology, allergology

Host institution :

Uniwersytet Warmińsko-Mazurski w Olsztynie, Wydział Lekarski

woj. warmińsko-mazurskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Marcin Przemysław Mycko 

Number of co-investigators in the project: 7

Call: OPUS 12 - announced on 2016-09-15

Amount awarded: 1 596 600 PLN

Project start date (Y-m-d): 2017-08-29

Project end date (Y-m-d): 2023-10-28

Project duration:: 74 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (12)
  • Articles in post-conference publications (4)
  1. Exosomal profiling should be used to monitor disease activity in MS patients: Yes
    Authors:
    Mycko MP
    Academic press:
    Multiple Sclerosis Journal (rok: 2023, tom: 10, strony: 1204– 1205), Wydawca: SAGE PUBLICATIONS LTD, 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
    Status:
    Published
    DOI:
    10.1177/13524585231195860 - link to the publication
  2. The Heat Shock Protein HSP70 Promotes Th17 Genes' Expression via Specific Regulation of microRNA
    Authors:
    Cwiklinska H, Cichalewska-Studzinska M, Selmaj KW, Mycko MP.
    Academic press:
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (rok: 2020, tom: 21, strony: 2823), Wydawca: MDPI, ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
    Status:
    Published
    DOI:
    10.3390/ijms21082823 - link to the publication
  3. microRNA and exosome profiling in multiple sclerosis
    Authors:
    Mycko MP; Baranzini SE
    Academic press:
    MULTIPLE SCLEROSIS JOURNAL (rok: 2020, tom: 26, strony: 599-603), Wydawca: SAGE PUBLICATIONS LTD, 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
    Status:
    Published
    DOI:
    10.1177/1352458519879303 - link to the publication
  4. Fluid phase biomarkers in multiple sclerosis
    Authors:
    Krzysztof W Selmaj, Marcin P Mycko, Roberto Furlan, Konrad Rejdak
    Academic press:
    Curr Opin Neurol (rok: 2022, tom: 35, strony: 286-292), Wydawca: Wolters Kluwer
    Status:
    Published
    DOI:
    10.1097/WCO.0000000000001058 - link to the publication
  5. microRNA and exosome profiling in multiple sclerosis
    Authors:
    Mycko MP; Baranzini SE
    Academic press:
    MULTIPLE SCLEROSIS JOURNAL (rok: 2020, tom: 26, strony: 599-603), Wydawca: SAGE PUBLICATIONS LTD, 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
    Status:
    Published
    DOI:
    10.1177/1352458519879303 - link to the publication
  6. Reconsidering the route of drug delivery in refractory multiple sclerosis: Toward a more effective drug accumulation in the central nervous system
    Authors:
    Kalkowski L, Walczak P, Mycko MP, Malysz-Cymborska I
    Academic press:
    Medical Research Review (rok: 2023, tom: 43, strony: 2237-2259), Wydawca: Wiley
    Status:
    Published
    DOI:
    10.1002/med.21973 - link to the publication
  7. Multiple Sclerosis: circRNA Profile Defined Reveals Links to B-Cell Function
    Authors:
    Anna E Zurawska, Marcin P Mycko, Igor Selmaj, Cedric S Raine , Krzysztof W Selmaj
    Academic press:
    Neurology Neuroimmunology Neuroinflammation (rok: 2021, tom: 8(5), strony: e1041), Wydawca: Wolters Kluwer
    Status:
    Published
    DOI:
    10.1212/NXI.0000000000001041 - link to the publication
  8. Impact of Diminished Expression of circRNA on Multiple Sclerosis Pathomechanisms
    Authors:
    Marcin P Mycko, Anna E Zurawska, Igor Selmaj, Krzysztof W Selmaj
    Academic press:
    Front Immunol (rok: 2022, tom: 13, strony: 875994), Wydawca: Frontiers
    Status:
    Published
    DOI:
    10.3389/fimmu.2022.875994 - link to the publication
  9. Linking Mechanisms of Vitamin D Signaling with Multiple Sclerosis.
    Authors:
    Carlberg C, Mycko MP.
    Academic press:
    Cells (rok: 2023, tom: 12, strony: 2391), Wydawca: MDPI Open Access Journals
    Status:
    Published
    DOI:
    10.3390/cells12192391 - link to the publication
  10. Fluid phase biomarkers in multiple sclerosis
    Authors:
    Krzysztof W Selmaj, Marcin P Mycko, Roberto Furlan, Konrad Rejdak
    Academic press:
    Curr Opin Neurol (rok: 2022, tom: 35, strony: 286-292), Wydawca: Wolters Kluwer
    Status:
    Published
    DOI:
    10.1097/WCO.0000000000001058 - link to the publication
  11. Circular RNAs as a novel layer of regulatory mechanism in multiple sclerosis.
    Authors:
    Zurawska A, Mycko MP, Selmaj KW
    Academic press:
    J Neuroimmunol. (rok: 2019, tom: 334, strony: 45665), Wydawca: ELSEVIER, RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
    Status:
    Published
    DOI:
    10.1016/j.jneuroim.2019.576971 - link to the publication
  12. The Heat Shock Protein HSP70 Promotes Th17 Genes' Expression via Specific Regulation of microRNA
    Authors:
    Cwiklinska H, Cichalewska-Studzinska M, Selmaj KW, Mycko MP.
    Academic press:
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (rok: 2020, tom: 21, strony: 2823), Wydawca: MDPI, ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
    Status:
    Published
    DOI:
    10.3390/ijms21082823 - link to the publication
  1. Genome-wide transcriptome analysis of MS exosomes
    Authors:
    M. Mycko, L. Paukszto, J.P. Jastrzebski, K. Selmaj
    Conference:
    Conference: 35th Congress of the European-Committee-for-Treatment-and-Research-in-Multiple-Sclerosis (ECTRIMS) / 24th Annual Conference of Rehabilitation in MS Location: Stockholm, SWEDEN (rok: 2019, ), Wydawca: SAGE PUBLICATIONS LTD, 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
    Data:
    konferencja SEP 11-13, 2019
    Status:
    Published
  2. Circular RNA expression profiling indicates proinflammatory mechanisms in relapsing-remitting MS
    Authors:
    Mycko M; Zurawska A; Selmaj K
    Conference:
    5th Congress of the European-Academy-of-Neurology (EAN) (rok: 2019, ), Wydawca: WILEY, 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
    Data:
    konferencja JUN 29-JUL 02, 2019
    Status:
    Published
  3. Non-coding circular RNA genomowide profiling in MS reveals a pathogenic circuit disrupting B cells
    Authors:
    M.P. Mycko, A. Zurawska, I. Selmaj, K. Selmaj
    Conference:
    38th Congress of the European-Committee-for-Treatment-and-Research-in-Multiple-Sclerosis (rok: 2022, ), Wydawca: SAGE
    Data:
    konferencja OCT 26-28
    Status:
    Published
  4. Circular RNA expression profiling indicates proinflammatory mechanisms in relapsing-remitting MS
    Authors:
    Mycko M; Zurawska A; Selmaj K
    Conference:
    5th Congress of the European-Academy-of-Neurology (EAN) (rok: 2019, ), Wydawca: WILEY, 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
    Data:
    konferencja JUN 29-JUL 02, 2019
    Status:
    Published

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