Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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In search of biochemical, mechanical and functional fingerprints of oxidative stress in RBCs

2016/23/B/ST4/00795

Keywords:

Raman spectroscopy (RS) Fourier transform infrared (FT-IR) spectroscopy atomic force microscopy (AFM) red blood cells (RBCs) oxidative stress

Descriptors:

  • ST4_3: Molecular architecture and structure
  • NZ1_3: Biophysics
  • ST4_13: Solid-state chemistry, surface physicochemistry

Panel:

ST4 - Chemistry: physical chemistry/chemical physics, theoretical chemistry, analytical chemistry, inorganic chemistry, organic chemistry, method development

Host institution :

Uniwersytet Jagielloński, Jagiellońskie Centrum Rozwoju Leków (JCET)

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Katarzyna Marzec 

Number of co-investigators in the project: 6

Call: OPUS 12 - announced on 2016-09-15

Amount awarded: 1 239 900 PLN

Project start date (Y-m-d): 2017-10-02

Project end date (Y-m-d): 2021-05-01

Project duration:: 43 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Dysku wewnętrzny SSD interface SATA III (134 PLN)
  2. Przenośny komputer/notebook wyposażony w niezbędne oprogramowanie.
  3. Laser do spektrometru (50 000 PLN)
  4. Ektacytometr (94 000 PLN)

Information in the final report

  • Publication in academic press/journals (10)
  • Articles in post-conference publications (7)
  1. Age–related and atherosclerosis–related erythropathy in ApoE/LDLR−/− mice
    Authors:
    J. Dybas, K. Bulat, A. Blat, T. Mohaissen, A. Wajda, M. Mardyla, M. Kaczmarska, M. Franczyk-Zarow, K. Malek, S. Chlopicki, K.M. Marzec
    Academic press:
    Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease (rok: 2020, tom: 1866 (12), strony: 165972 (1-11)), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.bbadis.2020.165972 - link to the publication
  2. Raman imaging of heme metabolism: In situ in macrophages and Kupffer cells
    Authors:
    J. Dybas, M. Grosicki, M. Baranska, K.M. Marzec
    Academic press:
    Analyst (rok: 2018, tom: 143, strony: 3489-3498), Wydawca: Royal Society of Chemistry
    Status:
    Published
    DOI:
    10.1039/C8AN00282G - link to the publication
  3. Probing the structure-function relationship of hemoglobin in living human red blood cells
    Authors:
    J. Dybas, M. J. Bokamper, K. M. Marzec, P. J. Mak
    Academic press:
    Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy (rok: 2020, tom: 239, strony: 118530), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.saa.2020.118530 - link to the publication
  4. Parasites under the Spotlight: Applications of Vibrational Spectroscopy to Malaria Research
    Authors:
    D. Perez-Guaita, K.M. Marzec, A. Hudson, C. Evans, T. Chernenko, C. Matthäus, M. Miljkovic, M. Diem, P. Heraud, J.S. Richards, D. Andrew, D.A. Anderson, C. Doerig, J. Garcia-Bustos, D. McNaughton, B.R. Wood
    Academic press:
    Chemical Reviews (rok: 2018, tom: 118(11), strony: 5330-5358), Wydawca: American Chemical Society
    Status:
    Published
    DOI:
    10.1021/acs.chemrev.7b00661 - link to the publication
  5. An analysis of isolated and intact RBC membranes – a comparison of a semi-quantitative approach by means of FTIR, nano-FTIR and Raman spectroscopies
    Authors:
    A. Blat, J. Dybas, M. Kaczmarska, K. Chrabaszcz, K. Bułat, R. B. Kostogrys, A. Cernescu, K. Malek, K. M. Marzec
    Academic press:
    Analytical Chemistry (rok: 2019, tom: 91 (15), strony: 9867-9874), Wydawca: American Chemical Society
    Status:
    Published
    DOI:
    10.1021/acs.analchem.9b01536 - link to the publication
  6. FTIR, Raman and AFM characterization of the clinically valid biochemical parameters in acute ischemic stroke
    Authors:
    A. Blat, J. Dybas, K. Chrabaszcz, K. Bulat, A. Jasztal, M. Kaczmarska, T. Popiela, A. Slowik, K. Malek, M.G. Adamski, K.M. Marzec
    Academic press:
    Scientific Reports (rok: 2019, tom: 9, strony: 15475), Wydawca: Nature Publishing Group
    Status:
    Published
    DOI:
    10.1038/s41598-019-51932-0 - link to the publication
  7. Temporal relationship between systemic endothelial dysfunction and alterations in erythrocyte function in a murine model of chronic heart failure
    Authors:
    T. Mohaissen, B. Proniewski, M. Targosz‐Korecka, A. Bar, A. Kij, K. Bulat, A. Wajda, A. Blat, K. Matyjaszczyk-Gwarda, M. Grosicki, A. Tworzydlo, R. Rodrigues-Diez, M. Sternak, K. Wojnar-Lason, A. Kubisiak, A. Briones, K. M. Marzec, S. Chlopicki
    Academic press:
    Cardiovascular Research (rok: 2021, tom: brak, strony: 1-17 (CVR-2020-1724)), Wydawca: Oxford Academic
    Status:
    Published
    DOI:
    10.1093/cvr/cvab306 - link to the publication
  8. Trends in biomedical analysis of red blood cells – Raman spectroscopy against other spectroscopic, microscopic and classical techniques
    Authors:
    J. Dybas, F.C. Alcicek, A. Wajda, M. Kaczmarska, A. Zimna, K. Bulat, A. Blat, T. Stepanenko, T. Mohaissen, E. Szczesny-Malysiak, D. Perez-Guaita, B.R. Wood, K.M. Marzec
    Academic press:
    Trands in analytical chemistry (TRAC) (rok: 2021, tom: brak, strony: 1-48 (Accepted Manuscript Nr: TRAC-D-21-00210R1 )), Wydawca: Elsevier
    Status:
    Accepted for publication
    DOI:
    10.1016/j.trac.2021.116481 - link to the publication
  9. Spectroscopic Signature of Red Blood Cells in the D-galactose-Induced Accelerated Aging Model
    Authors:
    A. Blat, T. Stepanenko, K. Bulat, A. Wajda, J. Dybas, T. Mohaissen, F. C. Alcicek, E. Szczesny- Malysiak, K. Malek, A. Fedorowicz, K.M. Marzec
    Academic press:
    International Journal of Molecular Sciences (rok: 2021, tom: 22, strony: 2660 (1-15).), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms22052660 - link to the publication
  10. Sex-specific differences of ATP levels in red blood cells isolated from ApoE/LDLR double-deficient mice
    Authors:
    F.C. Alcicek, T. Mohaissen, K. Bulat, J. Dybas, E. Szczesny-Malysiak, M. Kaczmarska, M. Franczyk-Zarow, R. Kostogrys, K.M. Marzec
    Academic press:
    Acta Physiologica (rok: 2021, tom: brak, strony: brak), Wydawca: Wiley
    Status:
    Submitted
    DOI:
    brak - link to the publication
  1. Resonance Raman Spectroscopy – fundamentals and biomedical applications
    Authors:
    K.M. Marzec
    Conference:
    ASC Winter School 2018 (rok: 2018, ), Wydawca: Wydział Chemii UJ
    Data:
    konferencja 28.02.2018.
    Status:
    Published
  2. Raman, FT-IR, AFM and complementary techniques in studies of the biochemical, mechanical and functional alterations in red blood cells
    Authors:
    K.M. Marzec, J. Dybas, A. Blat, M. Mardyła, K. Bulat, M. Baranska, S. Chlopicki
    Conference:
    XXXIV European Congress on Molecular Spectroscopy - EUCMOS 2018 (rok: 2018, ), Wydawca: Joao Duarte, Unipessoal, Lda-OGAMI
    Data:
    konferencja 19 -24 sierpień 2018
    Status:
    Published
  3. Studies of the chemically induced changes of the mechanical properties of murine RBCs with the use of Atomic Force Microscopy (AFM)
    Authors:
    K. Bulat, J. dybas, A. Blat, M. Mardyla, A. Rygula, S. Chlopicki, M. Baranska, K.M. Marzec
    Conference:
    Joint Conference of Three Societies: The European Society for Clinical Hemorheology and Microcirculation, The International Society of Clinical Hemorheology and The International Society of Biorheology (ESCHM-ISCH-ISB-2018) (rok: 2018, ), Wydawca: ESCHM-ISCH-ISB-2018
    Data:
    konferencja 2-6 Lipca 2018
    Status:
    Published
  4. Oxidative damage of the murine RBC membrane in advanced atherosclerosis studied by vibrational spectroscopy and AFM microscopy
    Authors:
    J. Dybas, A. Blat, K. Bulat, M. Mardyla, M. Baranska, S. Chlopicki, K.M. Marzec
    Conference:
    XXXIV European Congress on Molecular Spectroscopy - EUCMOS 2018 (rok: 2018, ), Wydawca: Joao Duarte, Unipessoal, Lda-OGAMI
    Data:
    konferencja 19-24 August 2018
    Status:
    Published
  5. Label-Free characterization of Acute Ischemic Stroke-Retrived Clot Composition with Vibrational Spectroscopy
    Authors:
    A. Blat, J. Dybas, K. Chrabaszcz, K. Bulat, A. Jasztal, T. Popiela, A. Slowik, S. Chlopicki, K. Malek, M.G. Adamski, K.M. Marzec
    Conference:
    XXXIV European Congress on Molecular Spectroscopy - EUCMOS 2018 (rok: 2018, ), Wydawca: Joao Duarte, Unipessoal, Lda-OGAMI
    Data:
    konferencja 19 -24 sierpień 2018
    Status:
    Published
  6. Monitoring of hemoglobin NOx – induced adducts inside functional erythrocytes
    Authors:
    J. Dybas, P. Berkowicz, B. Proniewski, K. Dziedzic-Kocurek, J. Stanek, M. Baranska, S. Chlopicki, K.M. Marzec
    Conference:
    International Society of Clinical Spectroscopy - SPEC 2018 (rok: 2018, ), Wydawca: University of Strathclyde
    Data:
    konferencja 10-15 czerwiec 2018
    Status:
    Published
  7. Zastosowanie spektroskopii oscylacyjnej i technik komplementarnych w obrazowaniu biomarkerów zmian chorobowych
    Authors:
    Katarzyna M. Marzec
    Conference:
    45 ZjazdFizykówPolskich (rok: 2019, ), Wydawca: Wydział Fizyki, Astronomii i Informatyki Stosowanej, Uniwersytet Jagielloński/Oddział Krakowski Polskiego Towarzystwa Fizycznego
    Data:
    konferencja 13-18.09.2019
    Status:
    Published

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