Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

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The role of brain glutamatergic system in the neuroendocrine regulation of cytochrome P450 expression and activity in the liver

2016/23/B/NZ7/02283

Keywords:

brain glutamatergic system ionotropic and metabotropic receptors hypothalamus pituitary neuroendocrine regulation liver cytochrome P450

Descriptors:

  • NZ7_14:

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Instytut Farmakologii PAN

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Władysława Anna Daniel 

Number of co-investigators in the project: 6

Call: OPUS 12 - announced on 2016-09-15

Amount awarded: 1 290 799 PLN

Project start date (Y-m-d): 2017-07-26

Project end date (Y-m-d): 2022-07-25

Project duration:: 60 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Wielofunkcyjny czytnik płytek (117 000 PLN)
  2. Zamrażarka niskotemperaturowa (-80 st. C) (62 000 PLN)

Information in the final report

  • Publication in academic press/journals (2)
  • Articles in post-conference publications (4)
  1. The effect of the selective NMDA receptor GluN2B subunit antagonist CP-101,606 on cytochrome P450 2D (CYP2D) expression and activity in the rat liver and brain
    Authors:
    Anna Haduch, Ewa Bromek, Renata Pukło, Joanna Jastrzębska, Przemysław J. Danek and Władysława A. Daniel
    Academic press:
    International Journal of Molecular Sciences (rok: 2022, tom: 23, strony: 45670), Wydawca: MDPI (Multidisciplinary Digital Publishing Institute, Basel Switzerland)
    Status:
    Published
    DOI:
    10.3390/ijms232213746 - link to the publication
  2. The mechanisms of interactions of psychotropic drugs with liver and brain cytochrome P450 and their significance for drug effect and drug-drug interactions
    Authors:
    Władysława A. Daniel, Ewa Bromek, Przemysław J. Danek and Anna Haduch
    Academic press:
    Biochemical Pharmacology (rok: 2022, tom: 199, strony: 115006), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.bcp.2022.115006 - link to the publication
  1. The effect of short- and long-termtreatment with NMDA receptor antagonist on the activity of cytochrome P450 in rat liver
    Authors:
    Wójcikowska O., Bromek E., Haduch A., Rysz M., Pukło R., Daniel W.A.
    Conference:
    NEURONUS 2020 IBRO Neuroscience Forum (rok: 2020, ), Wydawca: konferencja on-line
    Data:
    konferencja 8-11.12.
    Status:
    Published
  2. The positive allosteric modulator of mGlu5 receptor (VU 0360172), but not the mGlu2/3 receptor agonist (LY354740) affects liver cytochrome P450.
    Authors:
    Daniel W.A., Bromek E., Haduch A., Pukło R., Kot M.
    Conference:
    International Conference on cytochrome P450 (ICCP450) (), Wydawca: International Conference on cytochrome P450 (ICCP450)
    Data:
    konferencja 23-27.06.
    Status:
    Published
  3. The expression of cytochrome P450 in the liver is regulated by the GluN2B subunit NMDA receptor antagonist CP-101,606.
    Authors:
    Bromek E., Haduch A., Rysz M., Pukło R., Daniel W.A.
    Conference:
    International Conference on cytochrome P450 (ICCP450) (rok: 2019, ), Wydawca: International Conference on cytochrome P450 (ICCP450)
    Data:
    konferencja 23-27.06.
    Status:
    Published
  4. The positive allosteric modulator of mGlu5 receptor (VU 0360172), but not the mGlu2/3 receptor agonist (LY354740) affects liver cytochrome P450.
    Authors:
    Daniel W.A., Bromek E., Haduch A., Pukło R., Kot M.
    Conference:
    International Conference on cytochrome P450 (ICCP450) (rok: 2019, ), Wydawca: International Conference on cytochrome P450 (ICCP450)
    Data:
    konferencja 23-27.06.
    Status:
    Published

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