Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Mitofusin 2 role in cell death and cell survival in brain ischemia-reperfusion model

2016/23/D/NZ3/01631

Keywords:

mitofusin 2 autophagy mitochondrial biogenesis brain ischemia

Descriptors:

  • NZ3_6: Cell neurobiology
  • NZ3_7: Signal transduction

Panel:

NZ3 - Cellular and developmental biology: cell biology, developmental biology, ageing biology, neurobiology

Host institution :

Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego Polskiej Akademii Nauk

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Maria Kawalec 

Number of co-investigators in the project: 5

Call: SONATA 12 - announced on 2016-09-15

Amount awarded: 663 000 PLN

Project start date (Y-m-d): 2017-08-10

Project end date (Y-m-d): 2022-08-09

Project duration:: 60 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. kołyska laboratoryjna (4 000 PLN)
  2. Komputer stacjonarny z podstawowym oprogramowaniem i drukarką (10 000 PLN)
  3. Wytrząsarka laboratoryjna (1 500 PLN)
  4. dźwiękoszczelny sonikator laboratoryjny (30 000 PLN)

Information in the final report

  • Publication in academic press/journals (2)
  • Articles in post-conference publications (5)
  1. Mitofusin 2 integrates mitochondrial network remodelling, mitophagy and the renewal of respiratory chain proteins in neurons after oxygen and glucose deprivation
    Authors:
    Wojtyniak Piotr, Boratynska-Jasinska Anna, Serwach Karolina, Gruszczynska-Biegala Joanna, Zablocka Barbara, Jaworski Jacek, Kawalec Maria
    Academic press:
    Molecular Neurobiology (rok: 2022, tom: 59, strony: 6502–6518), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s12035-022-02981-6 - link to the publication
  2. Mitochondrial dynamics, elimination and biogenesis during post-ischemic recovery in ischemia-resistant and ischemia-vulnerable gerbil hippocampal regions
    Authors:
    Maria Kawalec, Piotr Wojtyniak, Ewelina Bielska, Anita Lewczuk, Anna Boratyńska-Jasińska, Małgorzata Beręsewicz-Haller, Małgorzata Frontczak-Baniewicz, Magdalena Gewartowska, Barbara Zabłocka
    Academic press:
    Biochimica et Biophysica Acta. Molecular Basis of Disease (rok: 2022, tom: -, strony: Online ahead of print), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.bbadis.2022.166633 - link to the publication
  1. Different role of mitochondrial autophagy and biogenesis in neuronal death and survival after transient brain ischemia in gerbils
    Authors:
    Piotr Wojtyniak, Ewelina Bielska, Anita Lewczuk, Anna Boratyńska-Jasińska, Małgorzata Beresewicz-Haller, Małgorzata Fronczak-Baniewicz, Magdalena Gewartowska, Barbara Zabłocka, Maria Kawalec
    Conference:
    Autophagy in brain health and disease (rok: 2022, ), Wydawca: EMBO
    Data:
    konferencja 11-14.05.2022
    Status:
    Published
  2. Different relations between autophagy and mitochondrial biogenesis during postischemic recovery in vulnerable and resistant hippocampal brain regions
    Authors:
    Wojtyniak P., Boratyńska-Jasińska A., Chęcińska A., Małek M., Zabłocka B., Kawalec M.
    Conference:
    FENS Regional Meeting 2021 (rok: 2021, ), Wydawca: Polish Neuroscience Society oraz Lithuanian Neuroscience Association
    Data:
    konferencja 25-27.08.2021
    Status:
    Published
  3. Mitochondrial dynamics during postischemic recovery of vulnerable and resistant regions of gerbil hippocampus
    Authors:
    Kawalec M., Wojtyniak P., Bielska E., Boratyńska-Jasińska A., Lewczuk A., Beręsewicz-Haller M., Frontczak-Baniewicz M., Zabłocka B.
    Conference:
    BRAIN and BRAIN-PET 2022 (rok: 2022, ), Wydawca: SAGE journals. Journal of Cerebral Blood Flow & Metabolism
    Data:
    konferencja 29.05.2022-1.06.2022
    Status:
    Published
  4. Mitofusin 2 role in mitophagy and mitochondria biogenesis in neurons after transient oxygen and glucose deprivation
    Authors:
    Wojtyniak P., Boratyńska-Jasińska A., Jaworski J., Zabłocka B., Kawalec M.
    Conference:
    Vesicle Trafficking & Pathways to Neurodegeneration (rok: 2021, ), Wydawca: Wellcome Trust
    Data:
    konferencja 17-19.05.2021
    Status:
    Published
  5. Role of mitofusin 2 in Pink1/parkin pathway in different models of brain ischemia
    Authors:
    Wojtyniak P., Boratyńska-Jasińska A., Małek M., Jaworski J., Zabłocka B., Kawalec M.
    Conference:
    Autophagy: From molecular principles to human diseases (rok: 2019, ), Wydawca: EMBO
    Data:
    konferencja 2019-08-26 do 2019-08-30
    Status:
    Published

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