Projects funded by the NCN
The research on the use of novel analogues of endogenous antimicrobial peptides in therapy of staphylococcal skin infections
2016/23/B/NZ7/02919
Keywords:
antimicrobial peptides LL37 lactoferricin staphylococci biofilm cytotoxicity peptide syntesis lipopeptides skin infection
Descriptors:
- NZ7_14: Pharmacy, pharmacotherapy, pharmacology
Panel:
NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology
Host institution :
Gdański Uniwersytet Medyczny, Wydział Farmaceutyczny
woj. pomorskie
Principal investigator (from the host institution):
Number of co-investigators in the project: 8
Call: OPUS 12 - announced on 2016-09-15
Amount awarded: 672 690 PLN
Project start date (Y-m-d): 2017-09-06
Project end date (Y-m-d): 2021-09-05
Project duration:: 48 months (the same as in the proposal)
Project status: Project settled
Project description
Download the project description in a pdf file
Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.
Equipment purchased [PL]
- Laptop (4 500 PLN)
- Termostat (16 000 PLN)
- Wyparka próżniowa z systemem próżniowym (31 000 PLN)
- Inkubator z wytrząsaniem (32 000 PLN)
- Wytrząsarka typu vortex (2 szt.) (4 000 PLN)
- Zestaw komputerowy (2 szt.) (8 000 PLN)
- Drukarka z możliwością kopiowania dokumentów (900 PLN)
Information in the final report
- Publication in academic press/journals (5)
- Lipidated Analogs of the LL-37-Derived Peptide Fragment KR12—Structural Analysis, Surface-Active Properties and Antimicrobial ActivityAuthors:Kamysz E., Sikorska E., Jaśkiewicz M., Bauer M., Neubauer D., Bartoszewska S., Barańska-Rybak W., Kamysz W.Academic press:International Journal of Molecular Sciences (rok: 2020, tom: 21, strony: 45313), Wydawca: MDPIStatus:PublishedDOI:10.3390/ijms21030887 - link to the publication
- Probing the binding selected metal ions and biologically active substances to the antimicrobial peptide LL-37 using DSC, ITC measurements and calculationsAuthors:Makowska J., Wyrzykowski D., Kamysz E., Tesmar E., Kamysz W., Chmurzyński LAcademic press:Journal of Thermal Analysis and Calorimetry (rok: 2019, tom: 138, strony: 4523–4529), Wydawca: SpringerStatus:PublishedDOI:10.1007/s10973-019-08310-9 - link to the publication
- Antimicrobial Activity of Different Antimicrobial Peptides (AMPs) Against Clinical Methicillin-resistant Staphylococcus aureus (MRSA)Authors:Ciandrini E., Morroni G., Arzeni D., Kamysz W., Neubauer D., Kamysz E., Cirioni O., Brescini L., Baffone W., Campana R.Academic press:Current Topics in Medicinal Chemistry, (rok: 2018, tom: 18, strony: 2116-2126), Wydawca: Bentham ScienceStatus:PublishedDOI:10.2174/1568026618666181022140348 - link to the publication
- Efficacy of Cathelicidin LL-37 in an MRSA Wound Infection Mouse ModelAuthors:Oriana Simonetti, Oscar Cirioni, Gaia Goteri, Guendalina Lucarini, Elżbieta Kamysz, Wojciech Kamysz, Fiorenza Orlando, Giulio Rizetto, Elisa Molinelli, Gianluca Morroni, Roberto Ghiselli, Mauro Provinciali, Andrea Giacometti, Annamaria OffidaniAcademic press:Antibiotics (rok: 2021, tom: 10, strony: 45303), Wydawca: MDPIStatus:PublishedDOI:10.3390/antibiotics10101210 - link to the publication
- Methods Used for the Eradication of Staphylococcal BiofilmsAuthors:Jaśkiewicz M., Janczura A., Nowicka J., Kamysz WAcademic press:Antibiotics (rok: 2019, tom: 8, strony: 45310), Wydawca: MDPIStatus:PublishedDOI:10.3390/antibiotics8040174 - link to the publication