Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

Delete all

Translational readthrough of premature termination codons (PTC readthrough) in genes mutated in primary ciliary dyskinesia - stimulation using non-aminoglycosides as an alternative for aminoglycoside antibiotics.

2016/23/N/NZ4/03228

Keywords:

primary ciliary dyskinesia premature termination codon readthrough aminoglycoside antibiotics nonsense mutations ciliopathies

Descriptors:

  • NZ3_1: Cell biology
  • NZ5_7: Human disease treatment
  • NZ4_12: Other related subjects

Panel:

NZ4 - Biology of tissues, organs and organisms: morphology and functions of animal's and human's systems, organs and organisms, experimental medicine, basics of neurology

Host institution :

Instytut Genetyki Człowieka Polskiej Akademii Nauk

woj. wielkopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

Maciej Dąbrowski 

Number of co-investigators in the project: 2

Call: PRELUDIUM 12 - announced on 2016-09-15

Amount awarded: 149 780 PLN

Project start date (Y-m-d): 2017-10-09

Project end date (Y-m-d): 2021-04-08

Project duration:: 42 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Laptop z oprogramowaniem (5 000 PLN)

Information in the final report

  • Publication in academic press/journals (2)
  • Articles in post-conference publications (1)
  • Book publications / chapters in book publications (1)
  1. Advances in therapeutic use of a drug-stimulated translational readthrough of premature termination codons
    Authors:
    Maciej Dabrowski, Zuzanna Bukowy-Bieryllo, Ewa Zietkiewicz
    Academic press:
    Molecular Medicine (rok: 2018, tom: 24, strony: 25), Wydawca: BioMed Central
    Status:
    Published
    DOI:
    10.1186/s10020-018-0024-7 - link to the publication
  2. Properties of Non-Aminoglycoside Compounds Used to Stimulate Translational Readthrough of PTC Mutations in Primary Ciliary Dyskinesia
    Authors:
    Maciej Dabrowski, Zuzanna Bukowy-Bieryllo, Claire L. Jackson, Ewa Zietkiewicz
    Academic press:
    International Journal of Molecular Sciences (rok: 2021, tom: 22, strony: 45305), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms22094923 - link to the publication
  1. Proceedings of the 4th BEAT-PCD Conference and 5th PCD Training School
    Authors:
    Laura E. Gardner, Katie L. Horton, Amelia Shoemark, Jane S. Lucas, Kim G. Nielsen, Helene Kobbernagel, Bruna Rubbo, Robert A. Hirst, Panayiotis Kouis, Nicola Ullmann, Ana Reula, Nisreen Rumman, Hannah M. Mitchison, Andreia Pinto, Charlotte Richardson, Anne Schmidt, James Thompson, René Gaupmann, Maciej Dabrowski, Pleasantine Mill, Siobhan B. Carr, Dominic P. Norris, Claudia E. Kuehni, Myrofora Goutaki & Claire Hogg
    Conference:
    4th BEAT-PCD Conference and 5th PCD Training School (rok: 2019, ), Wydawca: BMC Proceedings
    Data:
    konferencja 26-29.03
    Status:
    Published
  1. Stymulowany aminoglikozydami translacyjny odczyt przedwczesnych kodonów STOP w wybranych genach zaangażowanych w patogenezę pierwotnej dyskinezy rzęsek (PCD)
    Authors:
    Maciej Dąbrowski
    Book:
    Stymulowany aminoglikozydami translacyjny odczyt przedwczesnych kodonów STOP w wybranych genach zaangażowanych w patogenezę pierwotnej dyskinezy rzęsek (PCD) (rok: 2018, tom: 1, strony: 1-135), Wydawca: Instytut Genetyki Człowieka PAN
    Status:
    Published
    DOI:
    link to the publication

O Narodowym Centrum Nauki

Finansowanie nauki

Współpraca zagraniczna

Centrum prasowe

Deklaracja dostępności
Przetwarzanie danych osobowych
Polityka cookies

Partnerzy