Translational readthrough of premature termination codons (PTC readthrough) in genes mutated in primary ciliary dyskinesia - stimulation using non-aminoglycosides as an alternative for aminoglycoside antibiotics.
2016/23/N/NZ4/03228
Keywords
Descriptors
- NZ3_1: Biologia komórki
- NZ5_7: Leczenie chorób człowieka
- NZ4_12: Inne zagadnienia pokrewne
Panel
NZ4 – Biology of tissues, organs and organisms: morphology and functions of animal's and human's systems, organs and organisms, experimental medicine, basics of neurology
Host institution
Instytut Genetyki Człowieka PAN
Voivodeship: wielkopolskie
Principal investigator (from the host institution)
Number of co-investigators in the project: 2
Call
PRELUDIUM 12 – announced on 2016-09-15
- Amount awarded
- 149 780 PLN
- Project start date
- 2017-10-09
- Project end date
- 2021-04-08
- Project duration
- 42 months (the same as in the proposal)
- Project status
- Project settled
Project description
Download the project description in a pdf file
Note — project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.
Equipment purchased [PL]
- Laptop z oprogramowaniem. Cost: 5 000 PLN
Information in the final report
Publication in academic press/journals (2)
-
Advances in therapeutic use of a drug-stimulated translational readthrough of premature termination codons
- Authors:
- Maciej Dabrowski, Zuzanna Bukowy-Bieryllo, Ewa Zietkiewicz
- Academic press:
- Molecular Medicine (year: 2018, volume: 24, pages: 25), Publisher: BioMed Central
- Status:
- Published
- DOI:
- 10.1186/s10020-018-0024-7 – link to the publication
-
Properties of Non-Aminoglycoside Compounds Used to Stimulate Translational Readthrough of PTC Mutations in Primary Ciliary Dyskinesia
- Authors:
- Maciej Dabrowski, Zuzanna Bukowy-Bieryllo, Claire L. Jackson, Ewa Zietkiewicz
- Academic press:
- International Journal of Molecular Sciences (year: 2021, volume: 22, pages: 46036), Publisher: MDPI
- Status:
- Published
- DOI:
- 10.3390/ijms22094923 – link to the publication
Articles in post-conference publications (1)
-
Proceedings of the 4th BEAT-PCD Conference and 5th PCD Training School
- Authors:
- Laura E. Gardner, Katie L. Horton, Amelia Shoemark, Jane S. Lucas, Kim G. Nielsen, Helene Kobbernagel, Bruna Rubbo, Robert A. Hirst, Panayiotis Kouis, Nicola Ullmann, Ana Reula, Nisreen Rumman, Hannah M. Mitchison, Andreia Pinto, Charlotte Richardson, Anne Schmidt, James Thompson, René Gaupmann, Maciej Dabrowski, Pleasantine Mill, Siobhan B. Carr, Dominic P. Norris, Claudia E. Kuehni, Myrofora Goutaki & Claire Hogg
- Conference:
- 4th BEAT-PCD Conference and 5th PCD Training School (year: 2019, pages: 17), Publisher: BMC Proceedings
- Date:
- conference 26-29.03
- Status:
- Published
Book publications / chapters in book publications (1)
-
Stymulowany aminoglikozydami translacyjny odczyt przedwczesnych kodonów STOP w wybranych genach zaangażowanych w patogenezę pierwotnej dyskinezy rzęsek (PCD)
- Authors:
- Maciej Dąbrowski
- Book:
- Stymulowany aminoglikozydami translacyjny odczyt przedwczesnych kodonów STOP w wybranych genach zaangażowanych w patogenezę pierwotnej dyskinezy rzęsek (PCD) (year: 2018, volume: 1, pages: 1-135), Publisher: Instytut Genetyki Człowieka PAN
- Status:
- Published
- DOI:
- link to the publication