Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

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The role of the ESCRT-0 protein complex in viral RNA-dependent activation of TLR3 signaling in murine astrocytes

2016/23/N/NZ6/02499

Keywords:

TLR3 HRS STAM ESCRT-0 HSV-1 dsRNA HSE signal transduction innate immunity

Descriptors:

  • NZ6_1: Adaptive and innate immunity
  • NZ6_3: Animal immunology
  • NZ6_5: Virology

Panel:

NZ6 - Human and animal immunology and infection: immunity, immune disorders, immunotherapy, infectious and invasive diseases, microbiology, transplantology, allergology

Host institution :

Szkoła Główna Gospodarstwa Wiejskiego w Warszawie, Instytut Medycyny Weterynaryjnej

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

Matylda Mielcarska 

Number of co-investigators in the project: 2

Call: PRELUDIUM 12 - announced on 2016-09-15

Amount awarded: 150 000 PLN

Project start date (Y-m-d): 2017-10-04

Project end date (Y-m-d): 2021-10-03

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (5)
  • Articles in post-conference publications (2)
  1. Cell Surface Expression of Endosomal Toll-Like Receptors-A Necessity or a Superfluous Duplication?
    Authors:
    Matylda B. Mielcarska, Magdalena Bossowska-Nowicka, Felix N. Toka
    Academic press:
    Frontiers in Immunology (rok: 2021, tom: 11, strony: Article ID: 620972, pages 1-13), Wydawca: Frontiers
    Status:
    Published
    DOI:
    10.3389/fimmu.2020.620972 - link to the publication
  2. Participation of Endosomes in Toll-Like Receptor 3 Transportation Pathway in Murine Astrocytes
    Authors:
    Matylda B. Mielcarska, Karolina P. Gregorczyk-Zboroch, Lidia Szulc-Dąbrowska, Magdalena Bossowska-Nowicka, Zbigniew Wyżewski, Joanna Cymerys, Marcin Chodkowski, Paula Kiełbik, Michał M. Godlewski, Małgorzata Gieryńska, Felix N. Toka
    Academic press:
    Frontiers in Cellular Neuroscience (rok: 2020, tom: 14, strony: Article ID: 544612, pages 1-17), Wydawca: Frontiers
    Status:
    Published
    DOI:
    10.3389/fncel.2020.544612 - link to the publication
  3. Disrupting neurons and glial cells oneness in the brain – the possible causal role of herpes simplex virus type 1 (HSV-1) in Alzheimer's disease
    Authors:
    Matylda B. Mielcarska, Katarzyna Skowrońska, Zbigniew Wyżewski, Felix N. Toka
    Academic press:
    International Journal of Molecular Sciences (rok: 2021, tom: 23(1), strony: 32), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms23010242 - link to the publication
  4. Syk and Hrs Regulate TLR3-Mediated Antiviral Response in Murine Astrocytes
    Authors:
    Matylda B. Mielcarska, Magdalena Bossowska-Nowicka, Karolina P. Gregorczyk-Zboroch, Zbigniew Wyżewski, Lidia Szulc-Dąbrowska, Małgorzata Gieryńska, Felix N. Toka
    Academic press:
    Oxidative Medicine and Cellular Longevity (rok: 2019, tom: Volume 2019, strony: Article ID 6927380, 21 pages), Wydawca: Hindawi
    Status:
    Published
    DOI:
    10.1155/2019/6927380 - link to the publication
  5. Functional failure of TLR3 and its signaling components contribute to herpes simplex encephalitis
    Authors:
    Matylda Barbara Mielcarska, Magdalena Bossowska-Nowicka, Felix Ngosa Toka
    Academic press:
    Journal of Neuroimmunology (rok: 2018, tom: 316, strony: 65-73), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.jneuroim.2017.12.011 - link to the publication
  1. Influence of poly(I:C) stimulation on Syk and Hrs expression in C8-D1A murine astrocytes
    Authors:
    Mielcarska M. B., Bossowska-Nowicka M., Toka F. N.
    Conference:
    XIX Konferencja DIAGMOL 2018 "Biologia molekularna w diagnostyce chorób zakaźnych i biotechnologii" (rok: 2018, ), Wydawca: Wydawnictwo Szkoły Głównej Gospodarstwa Wiejskiego
    Data:
    konferencja 17 listopada
    Status:
    Published
  2. Knockdown of Syk and Hrs in murine astrocytes alters immune response following TLR3 stimulation
    Authors:
    Matylda B. Mielcarska, Magdalena Bossowska-Nowicka, Felix N. Toka
    Conference:
    XX Konferencja Diagmol 2019 "Biologia molekularna w diagnostyce chorób zakaźnych i biotechnologii" (rok: 2019, ), Wydawca: Wydawnictwo Szkoły Głównej Gospodarstwa Wiejskiego
    Data:
    konferencja 43792
    Status:
    Published

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