Projects funded by the NCN


Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

Delete all

The evaluation of protamine-induced thrombocytopenia and its potential thromboembolic complications in experimental animal models

2016/23/N/NZ7/00442

Keywords:

protamine heparin thrombocytopenia thrombosis

Descriptors:

  • NZ7_1: Epidemiology
  • NZ7_14: Pharmacy, pharmacotherapy, pharmacology
  • NZ7_15: Toxicology

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Uniwersytet Medyczny w Białymstoku, Wydział Farmaceutyczny z Oddziałem Medycyny Laboratoryjnej

woj. podlaskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

Joanna Mikłosz 

Number of co-investigators in the project: 3

Call: PRELUDIUM 12 - announced on 2016-09-15

Amount awarded: 148 000 PLN

Project start date (Y-m-d): 2017-09-01

Project end date (Y-m-d): 2021-08-31

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Waga półmikroanalityczna (15 000 PLN)
  2. Wielofunkcyjna platforma chirurgiczna (7 000 PLN)

Information in the final report

  • Publication in academic press/journals (3)
  • Articles in post-conference publications (5)
  1. Cardiovascular and respiratory toxicity of protamine sulfate in zebrafish and rodent models
    Authors:
    Joanna Mikłosz, Bartlomiej Kalaska, Piotr Podlasz, Małgorzata Chmielewska-Krzesińska, Miłosz Zajączkowski, Adam Kosiński, Dariusz Pawlak, Andrzej Mogielnicki
    Academic press:
    Pharmaceutics (rok: 2021, tom: 13(3), strony: 359), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/pharmaceutics13030359 - link to the publication
  2. The inhibitory effect of protamine on platelets is attenuated by heparin without inducing thrombocytopenia in rodents
    Authors:
    Joanna Miklosz, Bartłomiej Kalaska, Kamil Kaminski, Małgorzata Rusak, Krzysztof Szczubialka, Maria Nowakowska, Dariusz Pawlak, Andrzej Mogielnicki.
    Academic press:
    Marine Drugs (rok: 2019, tom: 17(9), strony: 45309), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/md17090539 - link to the publication
  3. Pharmacogenetic considerations of anticoagulant medication
    Authors:
    Joanna Mikłosz; Bartłomiej Kałaska; Andrzej Mogielnicki
    Academic press:
    Journal of Physiology and Pharmacology (rok: 2018, tom: 69, strony: 14 pp), Wydawca: Polish Physiological Society
    Status:
    Published
    DOI:
    10.26402/jpp.2018.4.01 - link to the publication
  1. Małopłytkowość indukowana protaminą oraz jej potencjalne powikłania zakrzepowo-zatorowe w eksperymentalnym modelu zwierzęcym.
    Authors:
    Joanna Mikłosz; Bartłomiej Kałaska; Dariusz Pawlak; Andrzej Mogielnicki
    Conference:
    XXII Międzynarodowy Kongres Polskiego Towarzystwa Kardiologicznego (rok: 2018, ), Wydawca: Via Medica
    Data:
    konferencja 13-15.09
    Status:
    Published
  2. The Role of Nitric Oxide and Cationic Groups in Cardiovascular and Respiratory Toxicity of Protamine Sulfate in Zebrafish and Rodent
    Authors:
    Joanna Mikłosz, Bartlomiej Kalaska, Piotr Podlasz, Małgorzata Chmielewska-Krzesińska, Miłosz Zajączkowski, Adam Kosiński, Dariusz Pawlak, Andrzej Mogielnicki
    Conference:
    XXIX Congress of the International Society of Thrombosis and Haemostasis (ISTH) (rok: 2021, ), Wydawca: Research and Practice in Thrombosis and Haemostasis
    Data:
    konferencja 2021-07-17-21
    Status:
    Published
  3. The interactions of protamine and heparin with platelets in rodents
    Authors:
    Joanna Mikłosz, Bartłomiej Kałaska, Kamil Kamiński, Małgorzata Rusak, Dominik Czaplicki, Joanna Bereta, Maria Nowakowska, Krzysztof Szczubiałka, Dariusz Pawlak, Andrzej Mogielnicki.
    Conference:
    XXVII Congress of the International Society of Thrombosis and Haemostasis (ISTH) (rok: 2019, ), Wydawca: Research and Practice in Thrombosis and Haemostasis
    Data:
    konferencja 2019-07-06-10
    Status:
    Published
  4. The effects of protamine sulfate on the hemostasis, cardiovascular and respiratory functions in different animal models.
    Authors:
    Joanna Mikłosz, Bartlomiej Kalaska, Piotr Podlasz, Małgorzata Chmielewska-Krzesińska, Miłosz Zajączkowski, Małgorzata Rusak, Adam Kosiński, Dariusz Pawlak, Andrzej Mogielnicki
    Conference:
    28th Congress of the Polish Physiological Society (rok: 2021, ), Wydawca: Journal of Physiology and Pharmacology
    Data:
    konferencja 2021-09-15-17
    Status:
    Published
  5. Antiplatelet effect of protamine is attenuated by heparin in rats and mice
    Authors:
    Aleksandra Jakimczuk, Joanna Mikłosz, Bartłomiej Kałaska, Dariusz Pawlak, Andrzej Mogielnicki
    Conference:
    6th Lublin International Medical Congress for Students and Young Doctors (rok: 2019, ), Wydawca: Students' Scientific Society, Medical University of Lublin
    Data:
    konferencja 28-30.11
    Status:
    Published