Projects funded by the NCN

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Information of the project and the call

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Impact of uremia on the shaping of systemic and local innate immune responses

2016/23/B/NZ6/00086

Keywords:

infections kidney uremic toxins innate immunity miRNA

Descriptors:

  • NZ6_1: Adaptive and innate immunity
  • NZ6_4: Bacteriology
  • NZ6_2: Clinical immunology

Panel:

NZ6 - Human and animal immunology and infection: immunity, immune disorders, immunotherapy, infectious and invasive diseases, microbiology, transplantology, allergology

Host institution :

Uniwersytet Jagielloński, Wydział Biochemii, Biofizyki i Biotechnologii

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Maciej Lech 

Number of co-investigators in the project: 4

Call: OPUS 12 - announced on 2016-09-15

Amount awarded: 1 225 900 PLN

Project start date (Y-m-d): 2017-08-09

Project end date (Y-m-d): 2022-08-08

Project duration:: 60 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (10)
  1. Aristolochic acid I determine the phenotype and activation of macrophages in acute and chronic kidney disease
    Authors:
    Mohsen Honarpisheh, Orestes Foresto-Neto , Stefanie Steiger, Franziska Kraft, Paulina Koehler, Ekaterina von Rauchhaupt, Jan Potempa, Karina Adamowicz, Joanna Koziel, Maciej Lech
    Academic press:
    Scientific Reports (rok: 2018, tom: 8, strony: 45304), Wydawca: Springer Nature
    Status:
    Published
    DOI:
    10.1038/s41598-018-30628-x - link to the publication
  2. IFN Regulatory Factor 4 Controls Post-ischemic Inflammation and Prevents Chronic Kidney Disease
    Authors:
    Georg Lorenz, Foteini Moschovaki-Filippidou, Vivian Würf, Philipp Metzger, Stefanie Steiger, Falk Batz, Javier Carbajo-Lozoya, Joanna Koziel, Max Schnurr, Clemens D. Cohen, Christoph Schmaderer, Hans-Joachim Anders, Maja Lindenmeyer and Maciej Lech
    Academic press:
    Front. Immunol. (rok: 2019, tom: 10, strony: 45306), Wydawca: Frontiers
    Status:
    Published
    DOI:
    10.3389/fimmu.2019.02162 - link to the publication
  3. The Vicious Circle: Uremia, Porphyromonas gingivalis Infection, and Kidney Inflammatory Disease Progression.
    Authors:
    Karina Adamowicz, Andrea Ribeiro, Anna Golda, Marta Wadowska, Jan Potempa, Christoph Schmaderer, Hans-Joachim Anders, Joanna Koziel, Maciej Lech
    Academic press:
    Journal of Innate immunity , Wydawca: Karger
    Status:
    Submitted
    DOI:
    brak - link to the publication
  4. Uremic Toxin Indoxyl Sulfate Promotes Macrophage-Associated Low-Grade Inflammation and Epithelial Cell Senescence.
    Authors:
    Ribeiro A, Liu F, Srebrzynski M, Rother S, Adamowicz K, Wadowska M, Steiger S, Anders HJ, Schmaderer C, Koziel J, Lech M.
    Academic press:
    International Journal of Molecular Sciences (rok: 2023, tom: 24(9), strony: 8031), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms24098031 - link to the publication
  5. •Epigenetic regulation of mitochondrial-endoplasmic reticulum dynamics in kidney diseases.
    Authors:
    Shelke V, Yelgonde V, Kale A, Lech M, Gaikwad AB.
    Academic press:
    Journal of Cellular Physiology (rok: 2023, tom: 238(8), strony: 1716-1731), Wydawca: Wiley
    Status:
    Published
    DOI:
    10.1002/jcp.31058. - link to the publication
  6. A randomized prospective cross over study on the effects of medium cut-off membranes on T cellular and serologic immune phenotypes in hemodialysis
    Authors:
    Georg Lorenz, Yuli Shen, Renate Ilona Hausinger, Caroline Scheid, Marie Eckermann, Sophia Hornung, Joana Cardoso, Maciej Lech, Andrea Ribeiro, Bernhard Haller, Christopher Holzmann-Littig, Dominik Steubl, Matthias C Braunisch, Roman Günthner , Andreas Poschenrieder, Britt Freitag, Mario Weber, Peter Luppa, Uwe Heemann, Christoph Schmaderer
    Academic press:
    Scientific Reports (rok: 2022, tom: 12(1):16419, strony: 45303), Wydawca: Nature Portfolio
    Status:
    Published
    DOI:
    10.1038/s41598-022-20818-z - link to the publication
  7. Hippo signaling in acute kidney injury to chronic kidney disease transition: Current understandings and future targets.
    Authors:
    Habshi T, Shelke V, Kale A, Lech M, Gaikwad AB.
    Academic press:
    Drug Discovery Today (rok: 2023, tom: 28(8), strony: 103649), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.drudis.2023.103649 - link to the publication
  8. Macrophage-Specific MCPIP1/Regnase-1 Attenuates Kidney Ischemia-Reperfusion Injury by Shaping the Local Inflammatory Response and Tissue Regeneration
    Authors:
    Andrea Ribeiro , Ewelina Dobosz , Moritz Krill , Paulina Köhler, Marta Wadowska, Stefanie Steiger, Christoph Schmaderer , Joanna Koziel , Maciej Lech
    Academic press:
    Cells (rok: 2022, tom: 11, strony: 16), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/cells11030397 - link to the publication
  9. Murine myeloid cell MCPIP1 suppresses autoimmunity by regulating B-cell expansion and differentiation
    Authors:
    Ewelina Dobosz , Georg Lorenz, Andrea Ribeiro , Vivian Würf , Marta Wadowska, Jerzy Kotlinowski , Christoph Schmaderer , Jan Potempa , Mingui Fu , Joanna Koziel , Maciej Lech
    Academic press:
    Disease Models & Mechanisms (DMM) (rok: 2021, tom: 14, strony: 13), Wydawca: The Company of Biologists
    Status:
    Published
    DOI:
    10.1242/dmm.047589 - link to the publication
  10. Systemic but not MDSC-specific IRF4 deficiency promotes an immunosuppressed tumor microenvironment in a murine pancreatic cancer model
    Authors:
    Metzger P, Kirchleitner SV, Boehmer DFR, Hörth C, Eisele A, Ormanns S, Gunzer M, Lech M, Lauber K, Endres S, Duewell P, Schnurr M, König LM.
    Academic press:
    Cancer Immunol Immunotherapy (rok: 2020, tom: 10, strony: 2101-2112), Wydawca: springer
    Status:
    Published
    DOI:
    10.1007/s00262-020-02605-9. - link to the publication

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