Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

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Characterization of a novel intracellular amplifier circuit that controls long-term responsiveness to type I and type II IFNs

2016/23/B/NZ2/00623

Keywords:

novel IFN signaling pathway STAT and IRF transcriptional regulation chromatin interactions interferon biology novel gene functions

Descriptors:

  • NZ2_7: Bioinformatics
  • NZ2_2: Genomics, transcriptomics, epigenomics
  • NZ2_1: Molecular genetics

Panel:

NZ2 - Genetics, genomics: molecular genetics, genomics, proteomics, bioinformatics, systems biology, genetic epidemiology

Host institution :

Uniwersytet im. Adama Mickiewicza w Poznaniu, Wydział Biologii

woj. wielkopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Johannes (Hans) Bluijssen (Bluyssen) 

Number of co-investigators in the project: 6

Call: OPUS 12 - announced on 2016-09-15

Amount awarded: 1 488 200 PLN

Project start date (Y-m-d): 2017-07-06

Project end date (Y-m-d): 2022-07-05

Project duration:: 60 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Zamrażarka.
  2. Wirowka (40 000 PLN)
  3. CO2 inkubator (65 000 PLN)
  4. Komputer wraz z monitorem.

Information in the final report

  • Publication in academic press/journals (5)
  • Book publications / chapters in book publications (1)
  1. Time-dependent recruitment of GAF, ISGF3 and IRF1 complexes shapes IFNα and IFNγ-activated transcriptional responses and explains mechanistic and functional overlap.
    Authors:
    Agata Sekrecka, Katarzyna Kluzek, Michal Sekrecki, Mahdi Eskandarian Boroujeni, Sanaz Hasani, Shota Yamauchi, Kiyonao Sada, Joanna Wesoly, Hans Bluyssen.
    Academic press:
    Cell. Mol. Life Sci. (rok: 2023, tom: 80, strony: 187), Wydawca: Springer Nature
    Status:
    Published
    DOI:
    10.1007/s00018-023-04830-8 - link to the publication
  2. Editorial: STATs and IRFs in Innate Immunity: From Transcriptional Regulators to Therapeutic Targets
    Authors:
    Chien-Kuo Lee and Hans A. R. Bluyssen
    Academic press:
    Frontiers in Immunology (rok: 2019, tom: 10, strony: 1829), Wydawca: Frontiers
    Status:
    Published
    DOI:
    10.3389/fimmu.2019.01829 - link to the publication
  3. Direct inhibition of IRF-dependent transcriptional regulatory mechanisms associated with disease
    Authors:
    Aleksandra M. Antończyk, Bart Krist, Malgorzata Szelag, Agata Michalska, Anna Piaszyk- Borychowska, Martyna Plens-Galaska, Joanna Wesoly, Hans A. Bluyssen
    Academic press:
    Frontiers in Immunology (rok: 2019, tom: 10, strony: 1176), Wydawca: Frontiers
    Status:
    Published
    DOI:
    10.3389/fimmu.2019.01176 - link to the publication
  4. A positive feedback amplifier circuit that regulates ISG expression and controls type I and type II IFN responses
    Authors:
    Michalska A, Blaszczyk K, Wesoly J, Bluyssen HA
    Academic press:
    Frontiers in Immunology (rok: 2018, tom: 9, strony: 1135), Wydawca: Frontiers
    Status:
    Published
    DOI:
    10.3389/fimmu.2018.01135 - link to the publication
  5. ISGF3 and STAT2/IRF9 Control Basal and IFN-Induced Transcription through Genome-Wide Binding of Phosphorylated and Unphosphorylated Complexes to Common ISRE-Containing ISGs.
    Authors:
    Nowicka, H.; Sekrecka, A.; Blaszczyk, K.; Kluzek, K.; Chang, C.; Wesoly, J.; Lee, C.; Bluyssen, H.A.R.
    Academic press:
    International Journal of Molecular Sciences (rok: 2023, tom: 24, strony: 17635), Wydawca: Multidisciplinary Digital Publishing Institute
    Status:
    Published
    DOI:
    10.3390/ - link to the publication
  1. eBook: STATs and IRFs in Innate Immunity: From Transcriptional Regulators to Therapeutic Targets
    Authors:
    editors: Chien-Kuo Lee and Hans A. R. Bluyssen
    Book:
    eBook: STATs and IRFs in Innate Immunity: From Transcriptional Regulators to Therapeutic Targets (rok: 2019, tom: n/d, strony: 1-219), Wydawca: Frontiers in Immunology
    Status:
    Published

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