Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

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The role of cGMP-dependent signaling in the regulation of expression and activity of deacetylase SIRT1: a novel mechanism of induction of insulin resistance in podocytes exposed to high glucose concentrations

2016/23/B/NZ4/03448

Keywords:

podocyte SIRT1 deacetylation PDE5 PKGI hyperglycemia insulin resistance

Descriptors:

  • NZ3_2: Cell physiology
  • NZ4_4: Pathophysiology
  • NZ3_1: Cell biology

Panel:

NZ4 - Biology of tissues, organs and organisms: morphology and functions of animal's and human's systems, organs and organisms, experimental medicine, basics of neurology

Host institution :

Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego Polskiej Akademii Nauk

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Dorota Rogacka 

Number of co-investigators in the project: 7

Call: OPUS 12 - announced on 2016-09-15

Amount awarded: 1 102 805 PLN

Project start date (Y-m-d): 2017-08-09

Project end date (Y-m-d): 2021-08-08

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Komora laminarna (70 000 PLN)
  2. Wirówka z chłodzeniem (30 000 PLN)
  3. Suchy blok grzejny na probówki 1.5 ml (3 200 PLN)
  4. System dokumentacji żeli i blotów (125 000 PLN)
  5. Zestaw do western blot (23 000 PLN)
  6. Zamrażarka niskotemperaturowa (38 000 PLN)

Information in the final report

  • Publication in academic press/journals (5)
  • Articles in post-conference publications (1)
  1. Inhibition of phosphodiesterase 5A by tadalafil improves SIRT1 expression and activity in insulin-resistant podocytes
    Authors:
    Dorota Rogacka, Patrycja Rachubik, Irena Audzeyenka, Tomasz Kulesza, Maria Szrejder, Dorota Myślińska, Stefan Angielski, Agnieszka Piwkowska
    Academic press:
    Cellular Signalling , Wydawca: Elsevier
    Status:
    Submitted
    DOI:
    brak - link to the publication
  2. Regulation of podocytes function by AMP-activated protein kinase
    Authors:
    Rogacka Dorota, Audzeyenka Irena, Piwkowska Agnieszka
    Academic press:
    Archives of Biochemistry and Biophysics (rok: 2020, tom: 692, strony: 108541), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.abb.2020.108541 - link to the publication
  3. Involvement of nitric oxide synthase/nitric oxide pathway in the regulation of SIRT1-AMPK crosstalk in podocytes: Impact on glucose uptake
    Authors:
    Rogacka Dorota, Audzeyenka Irena, Rachubik Patrycja, Szrejder Maria, Typiak Merlena, Angielski Stefan, Piwkowska Agnieszka
    Academic press:
    Archives of Biochemistry and Biophysics (rok: 2021, tom: 709, strony: 108985), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.abb.2021.108985 - link to the publication
  4. Insulin resistance in glomerular podocytes: potential mechanisms of induction
    Authors:
    Rogacka Dorota
    Academic press:
    Archives of Biochemistry and Biophysics (rok: 2021, tom: 710, strony: 109005), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.abb.2021.109005 - link to the publication
  5. Enhancement of cGMP/PKG-dependent pathway activity ameliorates hyperglycemia induced decrease in SIRT1-AMPK activity in podocytes: impact on glucose uptake and podocyte function
    Authors:
    Dorota Rogacka, Patrycja Rachubik, Irena Audzeyenka, Maria Szrejder, Tomasz Kulesza, Dorota Myślińska, Stefan Angielski, Agnieszka Piwkowska
    Academic press:
    Biochimica et Biophysica Acta - Molecular Cell Research (rok: 2022, tom: 1869, strony: 119362), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.bbamcr.2022.119362 - link to the publication
  1. NO/cGMP pathway modulates glucose uptake via regulation of SIRT1 deacetylase expression and activity in podocytes exposed to high glucose concentrations
    Authors:
    Rogacka Dorota, Audzeyenka Irena, Piwkowska Agnieszka
    Conference:
    European Renal Association-European Dialysis and Transplant Association 57th Virtual Congress (rok: 2020, ), Wydawca: Oxford University Press
    Data:
    konferencja 6-9.06.2020
    Status:
    Published

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