Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

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Editing of HNF1A gene in human induced pluripotent stem cells with CRISPR/Cas9 for disease modeling of endothelial (dys)function in maturity onset diabetes of the young (MODY)

2016/23/B/NZ1/01804

Keywords:

endothelium HNF1A diabetes

Descriptors:

  • NZ1_1: Molecular biology
  • NZ1_7: Cell engineering
  • NZ1_9: Biotechnology

Panel:

NZ1 - Molecular biology, structural biology, biotechnology: molecular biology, structural biology, biotechnology

Host institution :

Uniwersytet Jagielloński, Małopolskie Centrum Biotechnologii Uniwersytetu Jagiellońskiego

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Neli Kachamakova-Trojanowska 

Number of co-investigators in the project: 3

Call: OPUS 12 - announced on 2016-09-15

Amount awarded: 898 300 PLN

Project start date (Y-m-d): 2017-07-14

Project end date (Y-m-d): 2021-05-13

Project duration:: 46 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Komputer przenośny.

Information in the final report

  • Publication in academic press/journals (4)
  • Articles in post-conference publications (2)
  1. Integrated transcriptome and proteome analyses unveil cytoskeletal alterations in an endothelial model of monogenic diabetes
    Authors:
    Dawid Skoczek, Damian Kloska, Marta Targosz-Korecka, Jerzy Hohendorff, Marian Babincak, Krzysztof Szade, Aleksandra Kopacz, Maciej Malecki, Jacek Stepniewski, Neli Kachamakova-Trojanowska
    Academic press:
    Genome Medicine , Wydawca: BMC
    Status:
    Submitted
    DOI:
    brak - link to the publication
  2. Human iPSCs-Derived Endothelial Cells with Mutation in HNF1A as a Model of Maturity- Onset Diabetes of the Young
    Authors:
    Neli Kachamakova-Trojanowska, Jacek Stepniewski and Jozef Dulak
    Academic press:
    Cells (rok: 2019, tom: 8/1440, strony: 1440), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/cells8111440 - link to the publication
  3. Hypoxia as a Driving Force of Pluripotent Stem Cell Reprogramming and Differentiation to Endothelial Cells
    Authors:
    Paulina Podkalicka, Jacek Stepniewski, Olga Mucha, Neli Kachamakova-Trojanowska, Jozef Dulak, Agnieszka Loboda
    Academic press:
    Biomolecules (rok: 2020, tom: Nov 29; 10 (12), strony: 1614), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/biom10121614. - link to the publication
  4. Maturity onset diabetes of the young – new approaches for disease modelling
    Authors:
    Dawid Skoczek, Józef Dulak, Neli Kachamakova-Trojanowska
    Academic press:
    International Journal of Molecular Sciences (rok: 2021, tom: 22(14), strony: 21), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms22147553 - link to the publication
  1. Modeling of endothelial (dys)function in maturity onset diabetes of the young using induced pluripotent stem cells
    Authors:
    N. Kachamakova-Trojanowska, J. Stepniewski, E. Puente, J. Dulak
    Conference:
    44th FEBS Congress, From Molecules to Living Systems (rok: 2019, ), Wydawca: FEBS Press
    Data:
    konferencja 43652
    Status:
    Published
  2. HNF1A-MODY disease modeling in a dish - a possible role of IL-8 in the increased vascular permeability
    Authors:
    Skoczek D, Stepniewski J, Kamuda K , Dulak J, Kachamakova-Trojanowska N
    Conference:
    Frontiers in CardioVascular Biomedicine (rok: 2022, ), Wydawca: Oxford academic, Cardiovascular Research
    Data:
    konferencja 29th April – 1st May
    Status:
    Published

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