Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

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Maternal obesity and epigenetic programming: from gametogenesis to early embryo development

2016/23/B/NZ4/03737

Keywords:

epigenetics obesity methylome transcriptome oocyte embryo

Descriptors:

  • NZ2_2: Genomics, transcriptomics, epigenomics
  • NZ4_11: Metabolism
  • NZ4_6: Endocrinology

Panel:

NZ4 - Biology of tissues, organs and organisms: morphology and functions of animal's and human's systems, organs and organisms, experimental medicine, basics of neurology

Host institution :

Instytut Rozrodu Zwierząt i Badań Żywności Polskiej Akademii Nauk

woj. warmińsko-mazurskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Antonio Galvao 

Number of co-investigators in the project: 4

Call: OPUS 12 - announced on 2016-09-15

Amount awarded: 795 756 PLN

Project start date (Y-m-d): 2017-08-24

Project end date (Y-m-d): 2021-08-23

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (3)
  • Articles in post-conference publications (7)
  1. Leptin signaling in the ovary of diet-induced obese mice regulates activation of NOD-like receptor protein 3 inflammasome
    Authors:
    Adamowski, Marek; Wołodko, Karolina; Oliveira, Joana; Castillo-Fernandez, Juan; Murta, Daniel; Kelsey, Gavin; Galvão, António M.
    Academic press:
    Frontiers in Cell and Developmental Biology (rok: 2021, tom: 9, strony: art. no 738731 (1-17)), Wydawca: Frontiers
    Status:
    Published
    DOI:
    10.3389/fcell.2021.738731 - link to the publication
  2. Leptin Resistance in the Ovary of Obese Mice is Associated with Profound Changes in the Transcriptome of Cumulus Cells
    Authors:
    WOŁODKO, Karolina; WALEWSKA, Edyta; ADAMOWSKI, Marek; CASTILLO-FERNANDEZ, Juan; KELSEY, Gavin; GALVÃO, António M.
    Academic press:
    Journal of Cellular Physiology and Biochemistry (rok: 2020, tom: 54, strony: 417-437), Wydawca: Journal of Cellular Physiology and Biochemistry
    Status:
    Published
    DOI:
    10.33594/000000228 - link to the publication
  3. Revisiting the impact of local leptin signaling in folliculogenesis and oocyte maturation in obese mothers
    Authors:
    Wołodko, Karolina; Castillo-Fernandez, Juan; Kelsey, Gavin; Galvão, António M.
    Academic press:
    International Journal of Molecular Sciences (rok: 2021, tom: 22(5), strony: art. no 4270 (1-26)), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms22084270 - link to the publication
  1. Maternal obesity affects the epigenome of oocytes and preimplantation embryos.
    Authors:
    Galvão A, Clark S, Kelsey G
    Conference:
    Advances at the interface between metabolism and epigenetics (rok: 2019, ), Wydawca: Robinson College
    Data:
    konferencja 43481
    Status:
    Published
  2. Effects of maternal obesity on oocyte methylome are reflected on blastocyst epigenome
    Authors:
    Galvão A, Clark S, Wolodko K, Castillo-Fernandez J, Kelsey G
    Conference:
    Mechanisms and Evolution of Intergenerational Change (rok: 2019, ), Wydawca: Wellcome Trust Genome Campus
    Data:
    konferencja 43732
    Status:
    Published
  3. How Maternal Obesity Affects the Oocyte Epigenome and Preimplantation Embryos
    Authors:
    António Galvão, Stephen Clark, Gavin Kelsey
    Conference:
    3rd Danube COnference on Epigenetics (rok: 2018, ), Wydawca: FEBS
    Data:
    konferencja 9-12 October 2018
    Status:
    Published
  4. Maternal Obesity Affects the Oocyte Epigenome in Mice
    Authors:
    António Galvão , Karolina Wolodko, Marek Adamowski, Stephen Clark, Gavin Kelsey
    Conference:
    51st Society for Study of Reproduction Meeting, New Orleans, USA (rok: 2018, ), Wydawca: Biology of Reproduction
    Data:
    konferencja 10-13 July 2018
    Status:
    Published
  5. Impaired Decidualisation in Obese Mice is Associated with Altered Uterine Leptin Signalling
    Authors:
    Walewska E, Witek K, Kelsey G, Pérez-Garcia V, Galvão A
    Conference:
    9th Congress of the Society for Reproductive Biology (rok: 2021, ), Wydawca: TBR
    Data:
    konferencja 02-04.09.2021, Poznań
    Status:
    Published
  6. Obesity Alters Leptin Signalling in Mouse Uterus: Putative Link with Impaired Decidualisation
    Authors:
    Walewska E, Witek K, Kelsey G, Pérez-Garcia V, Galvão A
    Conference:
    Placental Biology course, Centre for Trophoblast Research (rok: 2021, ), Wydawca: Cambridge University
    Data:
    konferencja 9th July 2021
    Status:
    Published
  7. Obesity Alters Leptin Signalling in Mouse Uterus: Putative Link to Epigenetic Regulation during Decidualisation
    Authors:
    Walewska E, Witek K, Kelsey G, Galvão A
    Conference:
    Centre for Trophoblast Research Annual Conference (rok: 2019, ), Wydawca: Bioscientifica
    Data:
    konferencja 43654
    Status:
    Published

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