Intratumor heterogeneity and its role in cancer progression and prognosis; a study based on molecular imaging of cancer by MALDI-MSI
2016/23/B/NZ4/03901
Keywords
Descriptors
- NZ2_3: Proteomika
- NZ4_5: Patomorfologia
- NZ5_3: Patogeneza chorób człowieka
Panel
NZ4 – Biology of tissues, organs and organisms: morphology and functions of animal's and human's systems, organs and organisms, experimental medicine, basics of neurology
Host institution
Centrum Onkologii - Instytut im. Marii Skłodowskiej-Curie, Oddział w Gliwicach
Voivodeship: śląskie
Principal investigator (from the host institution)
Number of co-investigators in the project: 7
Call
OPUS 12 – announced on 2016-09-15
- Amount awarded
- 1 496 300 PLN
- Project start date
- 2017-08-30
- Project end date
- 2022-08-29
- Project duration
- 60 months (the same as in the proposal)
- Project status
- Project settled
Project description
Download the project description in a pdf file
Note — project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.
Equipment purchased [PL]
- Inkubatror to enzymatycznego trawienia preparatów tkankowych SunDigest. Cost: 86 000 PLN
- Laser smartbeam II do spektrometru ultrafleXtreme. Cost: 103 000 PLN
- Pakiet oprogramowania Matlab.
- Programowalny aparat do odparafinowywania preparatów tkankowych. Cost: 32 000 PLN
Information in the final report
Publication in academic press/journals (5)
-
Molecular Heterogeneity of Papillary Thyroid Cancer: Comparison of Primary Tumors and Synchronous Metastases in Regional Lymph Nodes by Mass Spectrometry Imaging
- Authors:
- Gawin M, Kurczyk A, Stobiecka E, Frątczak K, Polańska J, Pietrowska M, Widłak P
- Academic press:
- Endocrine Pathology (year: 2019, volume: 30, pages: 250-262), Publisher: Humana Press Inc.
- Status:
- Published
- DOI:
- 10.1007/s12022-019-09593-2 – link to the publication
-
Prognostic Value of Molecular Intratumor Heterogeneity in Primary Oral Cancer and Its Lymph Node Metastases Assessed by Mass Spectrometry Imaging
- Authors:
- Kurczyk A, Gawin M, Paul P, Chmielik E, Rutkowski T, Pietrowska M, Widłak P
- Academic press:
- Molecules (year: 2022, volume: 27(17), pages: e5458), Publisher: MDPI
- Status:
- Published
- DOI:
- 10.3390/molecules27175458 – link to the publication
-
Intra-Tumor Heterogeneity Revealed by Mass Spectrometry Imaging Is Associated with the Prognosis of Breast Cancer.
- Authors:
- Gawin M, Kurczyk A, Niemiec J, Stanek-Widera A, Grela-Wojewoda A, Adamczyk A, Biskup-Frużyńska M, Polańska J, Widłak P
- Academic press:
- Cancers (Basel) (year: 2021, volume: 13(17), pages: e4349), Publisher: MDPI
- Status:
- Published
- DOI:
- 10.3390/cancers13174349 – link to the publication
-
Discrimination of normal oral mucosa from oral cancer by mass spectrometry imaging of proteins and lipids
- Authors:
- Bednarczyk K, Gawin M, Chekan M, Kurczyk A, Mrukwa G, Pietrowska M, Polanska J, Widlak P
- Academic press:
- Journal of Molecular Histology (year: 2019, volume: 50, pages: 46032), Publisher: Springer
- Status:
- Published
- DOI:
- 10.1007/s10735-018-9802-3 – link to the publication
-
Classification of Thyroid Tumors Based on Mass Spectrometry Imaging of Tissue Microarrays; a Single-Pixel Approach
- Authors:
- 161. Kurczyk A, Gawin M, Chekan M, Wilk A, Łakomiec K, Mrukwa G, Frątczak K, Polanska J, Fujarewicz K, Pietrowska M, Widlak P
- Academic press:
- International Journal of Molecular Sciences (year: 2020, volume: 21(17), pages: e6289), Publisher: MDPI
- Status:
- Published
- DOI:
- 10.3390/ijms21176289 – link to the publication