Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Intratumor heterogeneity and its role in cancer progression and prognosis; a study based on molecular imaging of cancer by MALDI-MSI

2016/23/B/NZ4/03901

Keywords:

tumor heterogeneity proteomics molecular imaging molecular phenotype,

Descriptors:

  • NZ2_3: Proteomics
  • NZ4_5: Anatomical pathology
  • NZ5_3: Pathogenesis of human diseases

Panel:

NZ4 - Biology of tissues, organs and organisms: morphology and functions of animal's and human's systems, organs and organisms, experimental medicine, basics of neurology

Host institution :

Narodowy Instytut Onkologii im. Marii Skłodowskiej-Curie - Państwowy Instytut Badawczy, Oddział w Gliwicach

woj. śląskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Piotr Widłak 

Number of co-investigators in the project: 7

Call: OPUS 12 - announced on 2016-09-15

Amount awarded: 1 496 300 PLN

Project start date (Y-m-d): 2017-08-30

Project end date (Y-m-d): 2022-08-29

Project duration:: 60 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Inkubatror to enzymatycznego trawienia preparatów tkankowych SunDigest (86 000 PLN)
  2. Laser smartbeam II do spektrometru ultrafleXtreme (103 000 PLN)
  3. Pakiet oprogramowania Matlab.
  4. Programowalny aparat do odparafinowywania preparatów tkankowych (32 000 PLN)

Information in the final report

  • Publication in academic press/journals (5)
  1. Classification of Thyroid Tumors Based on Mass Spectrometry Imaging of Tissue Microarrays; a Single-Pixel Approach
    Authors:
    161. Kurczyk A, Gawin M, Chekan M, Wilk A, Łakomiec K, Mrukwa G, Frątczak K, Polanska J, Fujarewicz K, Pietrowska M, Widlak P
    Academic press:
    International Journal of Molecular Sciences (rok: 2020, tom: 21(17), strony: e6289), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms21176289 - link to the publication
  2. Intra-Tumor Heterogeneity Revealed by Mass Spectrometry Imaging Is Associated with the Prognosis of Breast Cancer.
    Authors:
    Gawin M, Kurczyk A, Niemiec J, Stanek-Widera A, Grela-Wojewoda A, Adamczyk A, Biskup-Frużyńska M, Polańska J, Widłak P
    Academic press:
    Cancers (Basel) (rok: 2021, tom: 13(17), strony: e4349), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/cancers13174349 - link to the publication
  3. Prognostic Value of Molecular Intratumor Heterogeneity in Primary Oral Cancer and Its Lymph Node Metastases Assessed by Mass Spectrometry Imaging
    Authors:
    Kurczyk A, Gawin M, Paul P, Chmielik E, Rutkowski T, Pietrowska M, Widłak P
    Academic press:
    Molecules (rok: 2022, tom: 27(17), strony: e5458), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/molecules27175458 - link to the publication
  4. Discrimination of normal oral mucosa from oral cancer by mass spectrometry imaging of proteins and lipids
    Authors:
    Bednarczyk K, Gawin M, Chekan M, Kurczyk A, Mrukwa G, Pietrowska M, Polanska J, Widlak P
    Academic press:
    Journal of Molecular Histology (rok: 2019, tom: 50, strony: 45301), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s10735-018-9802-3 - link to the publication
  5. Molecular Heterogeneity of Papillary Thyroid Cancer: Comparison of Primary Tumors and Synchronous Metastases in Regional Lymph Nodes by Mass Spectrometry Imaging
    Authors:
    Gawin M, Kurczyk A, Stobiecka E, Frątczak K, Polańska J, Pietrowska M, Widłak P
    Academic press:
    Endocrine Pathology (rok: 2019, tom: 30, strony: 250-262), Wydawca: Humana Press Inc.
    Status:
    Published
    DOI:
    10.1007/s12022-019-09593-2 - link to the publication

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