Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

Delete all

Impact of the coiled-coil segment on the functioning and assembly of yeast Rad50 dimer

2016/23/N/NZ1/00040

Keywords:

DNA damage double-strand breaks MRN complex Rad50 zinc hook

Descriptors:

  • NZ1_2: Biochemistry
  • NZ1_1: Molecular biology
  • NZ1_4: Structural biology

Panel:

NZ1 - Molecular biology, structural biology, biotechnology: molecular biology, structural biology, biotechnology

Host institution :

Uniwersytet Wrocławski, Wydział Biotechnologii

woj. dolnośląskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

Michał Padjasek 

Number of co-investigators in the project: 2

Call: PRELUDIUM 12 - announced on 2016-09-15

Amount awarded: 99 986 PLN

Project start date (Y-m-d): 2017-09-13

Project end date (Y-m-d): 2019-09-12

Project duration:: 24 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Spektrofotometr mikroobjętościowy (29 990 PLN)

Information in the final report

  • Publication in academic press/journals (1)
  • Articles in post-conference publications (2)
  1. Metal exchange in interprotein Zn(II)‐binding site of Rad50 hook domain – structural insights into Cd(II)‐induced DNA repair inhibition
    Authors:
    Michał Padjasek, Maciej Maciejczyk, Michał Nowakowski, Olga Kerber, Maciej Pyrka, Wiktor Koźmiński, Artur Krężel
    Academic press:
    Chemistry a European Journal (rok: 2019, ), Wydawca: John Wiley & Sons
    Status:
    Accepted for publication
    DOI:
    10.1002/chem.201904942 - link to the publication
  1. Single-molecule FRET reveals Zn(II)-dependent switch in S. cerevisiae Rad50 dimer's quaternary structure
    Authors:
    Michał Padjasek, Bartosz Krajnik, Adam Pomorski, Józef Tran, Artur Podhorecki, Artur Krężel
    Conference:
    FEBS CONGRESS 2018 (rok: 2018, ), Wydawca: FEBS openbio
    Data:
    konferencja 07-12.07
    Status:
    Published
  2. Single-molecule and molecular dynamics studies unravel the mystery of Rad50 zinc hook's conformational switch
    Authors:
    Michał Padjasek, Manuel David Peris-Diaz, Artur Krężel
    Conference:
    14th European Biological Inorganic Chemistry Conference (rok: 2018, ), Wydawca: University of Birmingham
    Data:
    konferencja 26-30.08
    Status:
    Published

O Narodowym Centrum Nauki

Finansowanie nauki

Współpraca zagraniczna

Centrum prasowe

Deklaracja dostępności
Przetwarzanie danych osobowych
Polityka cookies

Partnerzy