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The role of (R,S)-Sulforaphane-induced activation of Nrf2 transcription factor in the regulation of depressive-like behavior in the olfactory bulbectomy model in mice.

2016/23/N/NZ4/01337

Keywords

Descriptors

  • NZ3_5: Neurobiologia molekularna
  • NZ4_12: Inne zagadnienia pokrewne
  • NZ1_1: Biologia molekularna

Panel

NZ4 – Biology of tissues, organs and organisms: morphology and functions of animal's and human's systems, organs and organisms, experimental medicine, basics of neurology

Host institution

Uniwersytet Rzeszowski, Kolegium Nauk Medycznych

Voivodeship: podkarpackie

Other projects carried out by the institution »

Principal investigator (from the host institution)

dr Patrycja Anna Pańczyszyn-Trzewik

Number of co-investigators in the project: 2

Call

PRELUDIUM 12 – announced on 2016-09-15

Amount awarded
149 976 PLN
Project start date
2017-09-13
Project end date
2023-03-12
Project duration
66 months (the same as in the proposal)
Project status
Project settled

Project description

Download the project description in a pdf file

Note — project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

Publication in academic press/journals (3)

  1. Rola czynnika Nrf2 i jego aktywatorów w patogenezie wybranych chorób związanych z dysfunkcją układu nerwowego

    Authors:
    P. Pańczyszyn-Trzewik, A. Surowiec, J. Wnorowski, R. Zavatskyi, M. Sowa-Kućma
    Academic press:
    Postępy Biologii Komórki (year: 2020, volume: 47, pages: 101-118), Publisher: Postępy Biologii Komórki
    Status:
    Published

  2. The Importance of α-Klotho in Depression and Cognitive Impairment and Its Connection to Glutamate Neurotransmission : An Up-to-Date Review

    Authors:
    P.Pańczyszyn-Trzewik, E. Czechowska, K. Stachowicz, M. Sowa-Kućma
    Academic press:
    International Journal of Molecular Sciences (year: 2023, volume: Vol. 24, iss. 20, pages: 15268), Publisher: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms242015268 – link to the publication

  3. Oxidative stress responses and their alterations in the Nrf2-NMDA receptor pathway in the brain of suicide victims

    Authors:
    P.Pańczyszyn-Trzewik, P. Misztak, W. Opoka, G. Nowak, M. Sowa-Kućma
    Academic press:
    Journal of Physiology and Pharmacology (year: 2023, volume: Vol. 74, iss. 3, pages: 335-346), Publisher: Polish Physiological Society
    Status:
    Published
    DOI:
    10.26402/jpp.2023.3.08 – link to the publication

Articles in post-conference publications (5)

  1. Rola i potencjalne zastosowanie terapeutyczne sulforafanu w wybranych chorobach ośrodkowego układu nerwowego

    Authors:
    J. Jakubowska, P. Pańczyszyn-Trzewik, M. Sowa-Kućma
    Conference:
    III Ogólnopolska Konferencja Naukowa Przegląd i badania nad Ośrodkowym Układem Nerwowym - obecny stan wiedzy i perspektywy na przyszłość (year: 2022, pages: 24-25), Publisher: Wydawnictwo Naukowe TYGIEL Sp. z o. o
    Date:
    conference 14.10.2022
    Status:
    Published
    DOI:
    link to the publication

  2. Antidepressant-like effect of (R,S)- sulforaphane (an activator of Nrf2) in the olfactory bulbectomy model in mice

    Authors:
    P.Pańczyszyn-Trzewik, M. Sowa-Kućma, K. Stachowicz, P. Misztak, G. Nowak
    Conference:
    31st ECNP Congress, Barcelona - Hiszpania (year: 2019, pages: S128-S129), Publisher: European Neuropsychopharmacology
    Date:
    conference 6-9.10.2018
    Status:
    Published

  3. Alterations in Nrf2 Protein Level in The Frontal Cortex of Suicide Victims and Depressed Subjects are Associated with Nf κB(P65) Changes - Evidence From Post Mortem Brain Study

    Authors:
    P.Pańczyszyn-Trzewik, E. Sujkowska, S. Samojedny, M. Sowa-Kućma
    Conference:
    12th Neuronus 2022 Neuroscience Forum (year: 2022, pages: Vol. 82, supl. 1, s. 48), Publisher: Acta Neurobiologiae Experimentalis
    Date:
    conference 15-17.10.2022
    Status:
    Published

  4. Lipid Protein Balance in Major Depressive Disorder - Ftir and Raman Analysis in Post Mortem Human Frontal Cortex

    Authors:
    S. Samojedny, E. Sujkowska, P. Pańczyszyn-Trzewik, M. Sowa-Kućma
    Conference:
    12th Neuronus 2022 Neuroscience Forum (year: 2022, pages: Vol. 82, supl. 1, s. 47), Publisher: Acta Neurobiologiae Experimentalis
    Date:
    conference 15-17.10.2022
    Status:
    Published

  5. Depresja - nowe cele farmakoterapii

    Authors:
    E. Sujkowska, P.Pańczyszyn-Trzewik, M. Sowa-Kućma
    Conference:
    Ogólnopolska Konferencja Naukowa Zagrożenia zdrowia człowieka - przyczyny, stan obecny, sposoby na przyszłość (year: 2022, pages: 19-20), Publisher: Wydawnictwo Naukowe TYGIEL Sp. z o. o.
    Date:
    conference 26.05.2022
    Status:
    Published
    DOI:
    link to the publication

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