Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

Delete all

The second life of salinomycin: Chemo- and regioselective modifications of salinomycin and their influence on the anti-cancer and anti-microbial activity

2016/23/D/ST5/00242

Keywords:

Ionophores synthesis anticancer activity antimicrobial activity

Descriptors:

  • ST5_16:
  • ST5_23:

Panel:

ST5 - Materials: materials synthesis, structure-properties relations, advanced and functional materials with designed properties, (macro)molecular architecture, material engineering

Host institution :

Uniwersytet im. Adama Mickiewicza w Poznaniu, Wydział Chemii

woj. wielkopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Michał Antoszczak 

Number of co-investigators in the project: 5

Call: SONATA 12 - announced on 2016-09-15

Amount awarded: 726 338 PLN

Project start date (Y-m-d): 2017-07-11

Project end date (Y-m-d): 2020-07-10

Project duration:: 36 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Kolumny do HPLC (analityczne i preparatywne) (10 000 PLN)
  2. Modułowy, wielostanowiskowy system do syntezy równoległej (50 000 PLN)
  3. Kolumny do HPLC z wypełnieniem chiralnym (10 000 PLN)
  4. Komputer typu notebook (6 000 PLN)
  5. Laboratoryjna pompa strzykawkowa (15 000 PLN)
  6. Łaźnia (myjka) ultradźwiękowa (9 000 PLN)
  7. System do chromatografii typu FLASH i preparatywnej z detektorami UV oraz ELSD (300 000 PLN)
  8. Waga laboratoryjna (8 000 PLN)

Information in the final report

  • Publication in academic press/journals (14)
  • Articles in post-conference publications (1)
  • Book publications / chapters in book publications (1)
  1. A medicinal chemistry perspective on salinomycin as a potent anticancer and anti-CSCs agent
    Authors:
    M. Antoszczak*
    Academic press:
    European Journal of Medicinal Chemistry (rok: 2019, tom: 164, strony: 366-377), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.ejmech.2018.12.057 - link to the publication
  2. Overcoming resistance to platinum-based drugs in ovarian cancer by salinomycin and its derivatives – An in vitro study
    Authors:
    M. Michalak, M.S. Lach, M. Antoszczak, A. Huczyński, W.M. Suchorska
    Academic press:
    Molecules (rok: 2020, tom: 25, strony: 537), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/molecules25030537 - link to the publication
  3. Synthesis and anticancer activity of tertiary amides of salinomycin and their C20-oxo analogues
    Authors:
    D. Czerwonka, A. Urbaniak, S. Sobczak, S. Piña-Oviedo, T.C. Chambers, M. Antoszczak*, A. Huczyński
    Academic press:
    ChemMedChem (rok: 2020, tom: 15, strony: 236-246), Wydawca: Wiley
    Status:
    Published
    DOI:
    10.1002/cmdc.201900593 - link to the publication
  4. A comprehensive review of salinomycin derivatives as potent anticancer and anti-CSCs agents
    Authors:
    M. Antoszczak*
    Academic press:
    European Journal of Medicinal Chemistry (rok: 2019, tom: 166, strony: 48-64), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.ejmech.2019.01.034 - link to the publication
  5. Biological activity of doubly modified salinomycin analogs - Evaluation in vitro and ex vivo
    Authors:
    M. Antoszczak*, A. Urbaniak, M. Delgado, E. Maj, B. Borgstrom, J. Wietrzyk, A. Huczyński, Y. Yuan, T.C. Chambers, D. Strand
    Academic press:
    European Journal of Medicinal Chemistry (rok: 2018, tom: 156, strony: 510-523), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.ejmech.2018.07.021 - link to the publication
  6. Salinomycin and its derivatives – A new class of multiple-targeted magic bullets"
    Authors:
    M. Antoszczak, A. Huczyński
    Academic press:
    European Journal of Medicinal Chemistry (rok: 2019, tom: 176, strony: 208-227), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.ejmech.2019.05.031 - link to the publication
  7. Synteza i aktywność biologiczna pochodnych salinomycyny
    Authors:
    M. Antoszczak*, A. Huczyński, B. Brzezinski
    Academic press:
    Wiadomości Chemiczne (rok: 2017, tom: 71, strony: 629-661), Wydawca: Polskie Towarzystwo Chemiczne
    Status:
    Published
    DOI:
    brak - link to the publication
  8. Antibacterial activity of singly and doubly modified salinomycin derivatives
    Authors:
    M. Sulik, K. Stępień, J. Stefańska, A. Huczyński, M. Antoszczak*
    Academic press:
    Bioorganic & Medicinal Chemistry Letters (rok: 2020, tom: 30, strony: 127062), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.bmcl.2020.127062 - link to the publication
  9. Biokoniugaty antybiotyków jonoforowych - Cele, strategie syntezy i właściwości
    Authors:
    M. Antoszczak*, M. Kordylas, A. Huczyński
    Academic press:
    Wiadomości Chemiczne (rok: 2018, tom: 72, strony: 45319), Wydawca: Polskie Towarzystwo Chemiczne
    Status:
    Published
    DOI:
    brak - link to the publication
  10. Salinomycin derivatives exhibit activity against primary acute lymphoblastic leukemia (ALL) cells in vitro
    Authors:
    A. Urbaniak, M. Delgado, M. Antoszczak, A. Huczyński, T.C. Chambers
    Academic press:
    Biomedicine & Pharmacotherapy (rok: 2018, tom: 99, strony: 384-390), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.biopha.2018.01.081 - link to the publication
  11. Synthesis and anticancer activity of dimeric polyether ionophores
    Authors:
    M. Sulik, E. Maj, J. Wietrzyk, A. Huczyński, M. Antoszczak*
    Academic press:
    Biomolecules (rok: 2020, tom: 10, strony: 1039), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/biom10071039 - link to the publication
  12. Singly and doubly modified analogues of C20-epi-salinomycin: A new group of antiparasitic agents against Trypanosoma brucei
    Authors:
    D. Czerwonka, Y. Barcelos, D. Steverding, A. Cioch, A. Huczyński, M. Antoszczak*
    Academic press:
    European Journal of Medicinal Chemistry (rok: 2020, ), Wydawca: Elsevier
    Status:
    Accepted for publication
    DOI:
    10.1016/j.ejmech.2020.112900 - link to the publication
  13. Anti-parasitic activity of polyether ionophores
    Authors:
    M. Antoszczak, D. Steverding, A. Huczyński
    Academic press:
    European Journal of Medicinal Chemistry (rok: 2019, tom: 166, strony: 32-47), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.ejmech.2019.01.035 - link to the publication
  14. Anti-trypanosomal activity of doubly modified salinomycin derivatives
    Authors:
    M. Antoszczak*, D. Steverding, M. Sulik, J. Janczak, A. Huczyński
    Academic press:
    European Journal of Medicinal Chemistry (rok: 2019, tom: 173, strony: 90-98), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.ejmech.2019.03.061 - link to the publication
  1. Double modification of polyether ionophores: Synthesis and biological activity of novel salinomycin derivatives
    Authors:
    M. Antoszczak*, D. Czerwonka, A. Urbaniak, S. Sobczak, T.C. Chambers, A. Huczyński
    Conference:
    2nd Molecules Medicinal Chemistry Symposium (MMCS): Facing Novel Challenges in Drug Discovery (rok: 2019, ), Wydawca: MDPI
    Data:
    konferencja 43600
    Status:
    Published
  1. Zastosowanie antybiotyków jonoforowych oraz ich pochodnych w walce ze śpiączką afrykańską
    Authors:
    M. Sulik, M. Antoszczak*, A. Huczyński
    Book:
    Na pograniczu chemii i biologii (rok: 2019, tom: XXXIX, strony: 45557), Wydawca: Wydawnictwo Naukowe UAM
    Status:
    Published

O Narodowym Centrum Nauki

Finansowanie nauki

Współpraca zagraniczna

Centrum prasowe

Deklaracja dostępności
Przetwarzanie danych osobowych
Polityka cookies

Partnerzy