Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Chemoenzymatic cascades of multicomponent reactions

2016/23/B/ST5/03307

Keywords:

cascade reactions multicomponent reactions biocatalysis selectivity peptidomimetics

Descriptors:

  • ST4_11: Coordination and supramolecular chemistry
  • ST5_18:
  • ST4_12: Photochemistry

Panel:

ST5 - Materials: materials synthesis, structure-properties relations, advanced and functional materials with designed properties, (macro)molecular architecture, material engineering

Host institution :

Instytut Chemii Organicznej Polskiej Akademii Nauk

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Ryszard Ostaszewski 

Number of co-investigators in the project: 5

Call: OPUS 12 - announced on 2016-09-15

Amount awarded: 1 110 500 PLN

Project start date (Y-m-d): 2017-07-18

Project end date (Y-m-d): 2021-01-17

Project duration:: 42 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Mieszadła magnetyczne (10 000 PLN)
  2. Chromatograf gazowy z detektorem FID wyposażony w zestaw kolumn analitycznych na fazach normalnych oraz chiralnych (205 000 PLN)
  3. Wytrząsarka orbitalna (5 000 PLN)
  4. Kolumna HPLC z chiralną fazą stacjonarną.

Information in the final report

  • Publication in academic press/journals (19)
  1. Evaluation of alcohols as substrates for the synthesis of 3,4-dihydropyrimidin-2(1H)-ones under environmentally friendly conditions
    Authors:
    A. Kęciek, D. Paprocki, D. Koszelewski, R. Ostaszewski
    Academic press:
    CATALYSIS COMMUNICATIONS (rok: 2020, tom: 135, strony: 165-170), Wydawca: ELSEVIER, RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
    Status:
    Published
    DOI:
    10.1016/j.catcom.2019.105887 - link to the publication
  2. 1,2-Diarylethanols—A New Class of Compounds That Are Toxic to E. coli K12, R2–R4 Strains
    Authors:
    P. Kowalczyk, D. Trzepizur , M. Szymczak , G. Skiba, K. Kramkowski R. Ostaszewski
    Academic press:
    materials (rok: 2021, tom: 14, strony: 2015), Wydawca: Multidisciplinary Digital Publishing Institute
    Status:
    Published
    DOI:
    10.3390/ma - link to the publication
  3. Coumarin Derivatives as New Toxic Compounds to Selected K12, R1–R4 E. coli Strains
    Authors:
    P. Kowalczyk, A. Madej, D. Paprocki, M. Szymczak, R. Ostaszewski
    Academic press:
    Materials (rok: 2020, tom: 13, strony: 2499), Wydawca: Multidisciplinary Digital Publishing Institute
    Status:
    Published
    DOI:
    10.3390/ma13112499 - link to the publication
  4. Efficient assay for the detection of hydrogen peroxide via estimation of the enzyme promiscuous activity in the perhydrolysis reaction
    Authors:
    M. Wilk, R. Ostaszewski,
    Academic press:
    ChemBioChem (rok: 2021, tom: 22, strony: 1464-1469), Wydawca: WILEY-V C H VERLAG GMBH POSTFACH 101161, 69451 WEINHEIM, GERMANY
    Status:
    Published
    DOI:
    10.1002/cbic.202000770 - link to the publication
  5. The studies on chemoselective promiscuous activity of hydrolases on acylals transformations
    Authors:
    Koszelewski, Dominik; Ostaszewski, Ryszard
    Academic press:
    BIOORGANIC CHEMISTRY (rok: 2019, tom: 93, strony: 102825), Wydawca: ACADEMIC PRESS INC ELSEVIER SCIENCE
    Status:
    Published
    DOI:
    10.1016/j.bioorg.2019.02.050 - link to the publication
  6. The influence of the isocyanoesters structure on the course of enzymatic Ugi reactions
    Authors:
    Monika Wilk, Anna Brodzka, Dominik Koszelewski, Arleta Madej, Daniel Paprocki, Anna Żądło-Dobrowolska, Ryszard Ostaszewski
    Academic press:
    Bioorganic Chemistry (rok: 2019, tom: 93, strony: 102817), Wydawca: ACADEMIC PRESS INC ELSEVIER SCIENCE
    Status:
    Published
    DOI:
    10.1016/j.bioorg.2019.02.042 - link to the publication
  7. Enzyme Promiscuity as a Remedy for the Common Problems with Knoevenagel Condensation
    Authors:
    Dominik Koszelewski, Ryszard Ostaszewski
    Academic press:
    CHEMISTRY-A EUROPEAN JOURNAL (rok: 2019, tom: 25, strony: 10156-10164), Wydawca: WILEY-V C H VERLAG GMBH
    Status:
    Published
    DOI:
    10.1002/chem.201901491 - link to the publication
  8. Biocatalytic Promiscuity of Lipases in Carbon-Phosphorus Bond Formation
    Authors:
    Dominik Koszelewki, Ryszard Ostaszewski
    Academic press:
    CHEMCATCHEM (rok: 2019, tom: 11, strony: 2554-2558), Wydawca: WILEY-V C H VERLAG GMBH
    Status:
    Published
    DOI:
    10.1002/cctc.201900397 - link to the publication
  9. Environmental‑friendly one‑pot cascade synthesis of 3‑cyanopiperidin‑2,6‑diones
    Authors:
    Daniel Paprocki · Stanisław Berłożecki · Ryszard Ostaszewski
    Academic press:
    Environmental Chemistry Letters (rok: 2020, tom: 18, strony: 165-170), Wydawca: SPRINGER HEIDELBERG,
    Status:
    Published
    DOI:
    10.1007/s10311-019-00915-8 - link to the publication
  10. Evaluation of Biodegradable Glucose Based Surfactants as a Promoting Medium for the Synthesis of Peptidomimetics with the Coumarin Scaffold
    Authors:
    D. Paprocki, D. Koszelewski, A. Madej, A. Brodzka, P. Walde, R. Ostaszewski
    Academic press:
    ChemistrySelect (rok: 2020, tom: 5, strony: 9607 –9614), Wydawca: WILEY-V C H VERLAG GMBH POSTFACH 101161, 69451 WEINHEIM, GERMANY
    Status:
    Published
    DOI:
    10.1002/slct.202002266 - link to the publication
  11. Evaluation of droplet-based microfluidic platforms as a convenient tool for lipases and esterases assays
    Authors:
    Pawel Jankowskia, Adam Samborskia, Ryszard Ostaszewski, and Piotr Garstecki
    Academic press:
    PREPARATIVE BIOCHEMISTRY & BIOTECHNOLOGY (rok: 2019, tom: 49, strony: 727-734), Wydawca: TAYLOR & FRANCIS INC
    Status:
    Published
    DOI:
    10.1080/10826068.2019.1605527 - link to the publication
  12. Synthesis of (E)-α,β-unsaturated carboxylic esters derivatives from cyanoacetic acid via promiscuous enzyme-promoted cascade esterification/ Knoevenagel reaction
    Authors:
    Monika Wilk, Damian Trzepizur, Dominik Koszelewski, Anna Brodzka, Ryszard Ostaszewski
    Academic press:
    Bioorganic Chemistry (rok: 2019, tom: 93, strony: 102816), Wydawca: ACADEMIC PRESS INC ELSEVIER SCIENCE
    Status:
    Published
    DOI:
    10.1016/j.bioorg.2019.02.041 - link to the publication
  13. Synthesis of Enantiomerically Pure 5,6-Dihydropyran-2-ones via Chemoenzymatic Sequential DKR-RCM Reaction
    Authors:
    Dominik Koszelewski, Filip Borys, Anna Brodzka, Ryszard Ostaszewski
    Academic press:
    EUROPEAN JOURNAL OF ORGANIC CHEMISTRY (rok: 2019, tom: 209, strony: 1653-1658), Wydawca: WILEY-V C H VERLAG GMBH
    Status:
    Published
    DOI:
    10.1002/ejoc.201801819 - link to the publication
  14. The sustainable synthesis of peptidomimetics via chemoenzymatic tandem oxidation–Ugi reaction
    Authors:
    A. Madej, D. Koszelewski, D. Paprocki, A. Brodzka and R. Ostaszewski
    Academic press:
    RSC Advances (rok: 2018, tom: 8, strony: 28405 – 28413), Wydawca: ROYAL SOC CHEMISTRY THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLAND
    Status:
    Published
    DOI:
    10.1039/c8ra04583f - link to the publication
  15. The amine as carbonyl precursor in the chemoenzymatic synthesis of Passerini adducts in aqueous medium
    Authors:
    A. Madej, D. Koszelewski, D. Paprocki, A. Brodzka, R. Ostaszewski
    Academic press:
    Catalysis Communications (rok: 2020, tom: 145, strony: 106118), Wydawca: ELSEVIER RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS USA
    Status:
    Published
    DOI:
    10.1016/j.catcom.2020.106118 - link to the publication
  16. Wheat germ lipase: isolation, purification and applications
    Authors:
    Marcin Kublicki, Dominik Koszelewski, Anna Brodzka, Ryszard Ostaszewski
    Academic press:
    Critical Reviews in Biotechnology (rok: 2021, ), Wydawca: TAYLOR & FRANCIS LTD
    Status:
    Accepted for publication
    DOI:
    brak - link to the publication
  17. Dual activity of Grubbs-type catalyst in the transvinylation of carboxylic acids and ring closing-metathesis reactions
    Authors:
    A. Brodzka, D. Koszelewski,R. Ostaszewski
    Academic press:
    Journal of Organic Chemistry (rok: 2020, tom: 85, strony: 15305-15313), Wydawca: AMER CHEMICAL SOC 1155 16TH ST, NW, WASHINGTON, DC 20036
    Status:
    Published
    DOI:
    10.1021/acs.joc.0c02135 - link to the publication
  18. Multicomponent Reactions Accelerated by Aqueous Micelles
    Authors:
    Daniel Paprocki, Arleta Madej, Dominik Koszelewski, Anna Brodzka, Ryszard Ostaszewski
    Academic press:
    FRONTIERS IN CHEMISTRY (rok: 2018, tom: 6, strony: 45312), Wydawca: FRONTIERS MEDIA SA, AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
    Status:
    Published
    DOI:
    10.3389/fchem.2018.00502 - link to the publication
  19. Studies on the Synthesis of Endocyclic Enol Lactones via a RCM of Selected Vinyl Esters
    Authors:
    Anna Brodzka, Filip Borys, Dominik Koszelewski, Ryszard Ostaszewski
    Academic press:
    JOURNAL OF ORGANIC CHEMISTRY (rok: 2018, tom: 83, strony: 8655-8661), Wydawca: AMER CHEMICAL SOC, 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
    Status:
    Published
    DOI:
    10.1021/acs.joc.8b00807 - link to the publication

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