Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Novel strategies to accelerate homing of HSPCs and hematopoietic reconstitution after transplantation

2016/23/B/NZ3/03157

Keywords:

hematopoietic stem cells SDF-1 bioactive lipids priming effect hematopoietic transplants hematopoietic reconstitution

Descriptors:

  • NZ3_8: Stem cell biology
  • NZ3_1: Cell biology

Panel:

NZ3 - Cellular and developmental biology: cell biology, developmental biology, ageing biology, neurobiology

Host institution :

Warszawski Uniwersytet Medyczny, Wydział Lekarski

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Mariusz Ratajczak 

Number of co-investigators in the project: 5

Call: OPUS 12 - announced on 2016-09-15

Amount awarded: 1 737 300 PLN

Project start date (Y-m-d): 2017-08-17

Project end date (Y-m-d): 2021-08-16

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Instrument PCR do analiz ekspresji genów w czasie rzeczywistym (150 000 PLN)
  2. Analizator hematologiczny (80 000 PLN)
  3. Instrument do magnetycznego sortowania komórek (180 000 PLN)

Information in the final report

  • Publication in academic press/journals (17)
  1. Signaling of the Complement Cleavage Product Anaphylatoxin C5a Through C5aR (CD88) Contributes to Pharmacological Hematopoietic Stem Cell Mobilization
    Authors:
    Kamila Bujko, Sylwia Rzeszotek, Kai Hoehlig, Jun Yan, Axel Vater, Mariusz Z. Ratajczak
    Academic press:
    Stem Cell Reviews and Reports (rok: 2017, tom: 13, strony: 793-800), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s12015-017-9769-6 - link to the publication
  2. The Complement Cascade as a Mediator of Human Malignant Hematopoietic Cell Trafficking
    Authors:
    Anna Lenkiewicz, Kamila Bujko, Katarzyna Brzezniakiewicz-Janus, Bing Xu, Mariusz Z. Ratajczak
    Academic press:
    Frontiers in Immunology (rok: 2019, tom: 10, strony: 1292), Wydawca: Frontiers
    Status:
    Published
    DOI:
    10.3389/fimmu.2019.01292 - link to the publication
  3. The Inhibition of CD39 and CD73 Cell Surface Ectonucleotidases by Small Molecular Inhibitors Enhances the Mobilization of Bone Marrow Residing Stem Cells by Decreasing the Extracellular Level of Adenosine
    Authors:
    Mateusz Adamiak, Kamila Bujko, Katarzyna Brzezniakiewicz-Janus, Magda Kucia, Janina Ratajczak, Mariusz Z. Ratajczak
    Academic press:
    Stem Cell Reviews and Reports (rok: 2019, tom: 15, strony: 892-899), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s12015-019-09918-y - link to the publication
  4. The emerging Link Between the Complement Cascade and Purinergic Signaling in Stress Hematopoiesis
    Authors:
    Mariusz Z. Ratajczak, Mateusz Adamiak, Magda Kucia, William Tse, Janina Ratajczak, Wieslaw Wiktor-Jedrzejczak
    Academic press:
    Frontiers in Immunology (rok: 2018, tom: 9, strony: bd), Wydawca: bd
    Status:
    Published
    DOI:
    10.3389/fimmu.2018.01295 - link to the publication
  5. Bioactive phospholipids enhance migration and adhesion of human leukemic cells by inhibiting heme oxygenase 1 (HO-1) and inducible nitric oxygenase synthase (iNOS) in a p38 MAPK-dependent manner
    Authors:
    Ahmed Abdelbaset-Ismail, Monika Cymer, Sylwia Borkowska-Rzeszotek, Katarzyna Brzeźniakiewicz-Janus, Pranela Rameshwar, Sham S. Kakar, Janina Ratajczak, Mariusz Z. Ratajczak
    Academic press:
    Stem Cell Reviews and Reports (rok: 2019, tom: 1, strony: 139-154), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s12015-018-9853-6. - link to the publication
  6. Innate Immunity Communicates Using the Language of Extracellular Microvesicles
    Authors:
    Mariusz Z. Ratajczak, Janina Ratajczak
    Academic press:
    Stem Cell Reviews and Reports (rok: 2021, tom: 2, strony: 502-510), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s12015-021-10138-6 - link to the publication
  7. Novel Evidence that Purinergic Signaling - Nlrp3 Inflammasome Axis Regulates Circadian Rhythm of Hematopoietic Stem/Progenitor Cells Circulation in Peripheral Blood
    Authors:
    Mateusz Adamiak, Andrzej Ciechanowicz, Marta Skoda, Monika Cymer, Michal Tracz, Bing Xu, Mariusz Z. Ratajczak
    Academic press:
    Stem Cell Reviews and Reports (rok: 2020, tom: 1, strony: 45300), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s12015-020-09953-0 - link to the publication
  8. Nlrp3 Inflammasome Signaling Regulates the Homing and Engraftment of Hematopoietic Stem Cells (HSPCs) by Enhancing Incorporation of CXCR4 Receptor into Membrane Lipid Rafts
    Authors:
    Mateusz Adamiak, Ahmed Abdel-Latif, Kamila Bujko, Arjun Thapa, Krzysztof Anusz, Michał Tracz, Katarzyna Brzezniakiewicz-Janus, Janina Ratajczak, Magda Kucia, and Mariusz Z. Ratajczak
    Academic press:
    Stem Cell Reviews and Reports (rok: 2020, tom: 5, strony: 954-967), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s12015-020-10005-w - link to the publication
  9. A Novel Evidence That Mannan Binding Lectin (MBL) Pathway of Complement Cascade Activation is Involved in Homing and Engraftment of Hematopoietic Stem Progenitor Cells (HSPCs)
    Authors:
    Mateusz Adamiak, Monika Cymer, Krzysztof Anusz, Michał Tracz, and Mariusz Z. Ratajczak
    Academic press:
    Stem Cell Reviews and Reports (rok: 2020, tom: 4, strony: 693-701), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s12015-020-09983-8 - link to the publication
  10. ATP-Nlrp3 Inflammasome-Complement Cascade Axis in Sterile Brain Inflammation in Psychiatric Patients and its Impact on Stem Cell Trafficking
    Authors:
    Mariusz Z. Ratajczak, Aaron Mack, Kamila Bujko, Alison Domingues, Daniel Pedziwiatr, Magda Kucia, Janina Ratajczak, Henning Ulrich, Jolanta Kucharska-Mazur, Jerzy Samochowiec
    Academic press:
    Stem Cell Reviews (rok: 2019, tom: 15, strony: 497-505), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s12015-019-09888-1 - link to the publication
  11. Cancer from the perspective of stem cells and misappropriated tissue regeneration mechanisms
    Authors:
    Mariusz Z. Ratajczak, Kamila Bujko, Aaron Mack, Magda Kucia, Janina Ratajczak
    Academic press:
    Leukemia (rok: 2018, tom: 32, strony: 2519-2526), Wydawca: Springer Nature
    Status:
    Published
    DOI:
    10.1038/s41375-018-0294-7 - link to the publication
  12. Sterile inflammation of Brain, due to Activation of innate immunity, as a Culprit in Psychiatric Disorders
    Authors:
    Mariusz Z. Ratajczak, Daniel Pedziwiatr, Monika Cymer, Magda Kucia, Jolanta Kucharska-Mazur, Jerzy Samochowiec
    Academic press:
    Frontiers in Psychiatry (rok: 2018, tom: 9, strony: bd), Wydawca: bd
    Status:
    Published
    DOI:
    10.3389/fpsyt.2018.00060 - link to the publication
  13. A Circadian Rhythm in both Complement Cascade (ComC) Activation and Sphingosine-1-Phosphate (S1P) Levels in Human Peripheral Blood Supports a Role for the ComC–S1P Axis in Circadian Changes in the Number of Stem Cells Circulating in Peripheral Blood
    Authors:
    Marta Budkowska, Ewa Ostrycharz, Adrianna Wojtowicz, Zuzanna Marcinowska, Jarosław Woźniak, Mariusz Z. Ratajczak, Barbara Dołęgowska
    Academic press:
    Stem Cell Reviews and Reports (rok: 2018, tom: 14, strony: 677-685), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s12015-018-9836-7 - link to the publication
  14. An Overview of Novel Unconventional Mechanisms of Hematopoietic Development and Regulators of Hematopoiesis – a Roadmap for Future Investigations
    Authors:
    Kamila Bujko, Monika Cymer, Mateusz Adamiak, Mariusz Z. Ratajczak
    Academic press:
    Stem Cell Reviews and Reports (rok: 2019, tom: 15, strony: 785-794), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s12015-019-09920-4 - link to the publication
  15. Analysis of the Paternally-Imprinted DLK1–MEG3 and IGF2–H19 Tandem Gene Loci in NT2 Embryonal Carcinoma Cells Identifies DLK1 as a Potential Therapeutic Target
    Authors:
    Zachariah Payne Sellers, Gabriela Schneider, Magdalena Maj, Mariusz Z. Ratajczak
    Academic press:
    Stem Cell Reviews and Reports (rok: 2018, tom: 14, strony: 823-836), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s12015-018-9838-5 - link to the publication
  16. Novel evidence that extracellular nucleotides and purinergic signaling induce innate immunity-mediated mobilization of hematopoietic stem/progenitor cells
    Authors:
    Mateusz Adamiak, Kamila Bujko, Monika Cymer, Monika Plonka, Talita Glaser, Magda Kucia, Janina Ratajczak, Henning Ulrich, Ahmed Abdel-Latif, Mariusz Z. Ratajczak
    Academic press:
    Leukemia (rok: 2018, tom: 32, strony: 1920-1931), Wydawca: Springer Nature
    Status:
    Published
    DOI:
    10.1038/s41375-018-0122-0 - link to the publication
  17. Pannexin-1 channel fuels" by releasing ATP from bone marrow cells a state of sterile inflammation required for optimal mobilization and homing of hematopoietic stem cells
    Authors:
    Monika Cymer, Katarzyna Brzezniakiewicz-Janus, Kamila Bujko, Arjun Thapa, Janina Ratajczak, Krzysztof Anusz, Michał Tracz, Agnieszka Jackowska-Tracz, Mariusz Z. Ratajczak, and Mateusz Adamiak
    Academic press:
    Purinergic Signalling (rok: 2020, tom: 3, strony: 313-325), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s11302-020-09706-1 - link to the publication

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