Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Smart nanoparticles based on polylactides copolymers and their stereocomplexes as potential delivery systems of biological active compounds

2016/23/D/ST5/02458

Keywords:

polylactide stereocomplexes nanoparticles drug-delivery carriers

Descriptors:

  • ST5_10: Functional materials/nanomaterials, nanoparticles
  • ST5_11: Smart materials – self assembled materials, external stimuli-responsive materials
  • ST5_22:

Panel:

ST5 - Materials: materials synthesis, structure-properties relations, advanced and functional materials with designed properties, (macro)molecular architecture, material engineering

Host institution :

Centrum Badań Molekularnych i Makromolekularnych Polskiej Akademii Nauk

woj. łódzkie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Marek Brzeziński 

Number of co-investigators in the project: 2

Call: SONATA 12 - announced on 2016-09-15

Amount awarded: 575 500 PLN

Project start date (Y-m-d): 2017-07-19

Project end date (Y-m-d): 2021-07-18

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Komputer przenośny (2 szt.) (8 000 PLN)
  2. Krany do linii próźniowej.
  3. Pompy infuzyjne PHD ULTRA™ (4 szt.) (72 000 PLN)
  4. Laptop Lenovo.
  5. Linia próżniowa (2 szt.) (20 000 PLN)
  6. Wirówka 50mL (10 000 PLN)
  7. Myjka ultradźwiękowa Sonic-5.
  8. Program MestReNova (4 000 PLN)
  9. Program Sigma Plot (3 szt.) (9 000 PLN)
  10. Kamera CDD (Carl Zeiss) (30 000 PLN)
  11. Mikroskop optyczny z kamerą (Microscope Primovert iLED) (45 000 PLN)
  12. Program CorelDRAW X8 (2 szt.) (6 000 PLN)
  13. Suszarka.
  14. Wyciągarka pipet P 97 (40 000 PLN)

Information in the final report

  • Publication in academic press/journals (13)
  1. Simultaneous Stereocomplexation of Polylactides during Polymerization of d-LA in the Presence of a PLLA Template
    Authors:
    Marek Brzeziński, Adam Michalski, Bartłomiej Kost, Marta Socka, Marcin Florczak, Grzegorz Łapienis, Tadeusz Biela
    Academic press:
    Macromol. Chem. Phys. (rok: 2020, tom: 221, strony: 1900571), Wydawca: Wiley
    Status:
    Published
    DOI:
    10.1002/macp.201900571 - link to the publication
  2. Microfluidic-assisted nanoprecipitation of biodegradable nanoparticles composed of PTMC/PCL (co)polymers, tannic acid and doxorubicin for cancer treatment
    Authors:
    Brzeziński, M., Socka, M., Makowski, T., Kost, B., Cieślak, M., Królewska-Golińska, K.
    Academic press:
    Colloids and Surfaces B: Biointerfaces (rok: 2021, tom: 201, strony: 111598), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.colsurfb.2021.111598 - link to the publication
  3. Nanobiocatalyst from lipase non-covalently immobilized on multiwalled carbon nanotubes for copolymerization of ε-caprolactone and trimethylene carbonate
    Authors:
    Marta Socka, Magdalena Sitko, Sławomir Boncel, Bartłomiej Kost, Anna Chrobok, Marek Brzezinski
    Academic press:
    Polymer Degradation and Stability (rok: 2019, tom: 170, strony: 109000), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.polymdegradstab.2019.109000 - link to the publication
  4. Stereocomplexed PLA microspheres: Control over morphology, drug encapsulation and anticancer activity
    Authors:
    M. Brzeziński, B. Kost, S. Wedepohl, M. Socka, T. Biela, M. Calderón
    Academic press:
    Colloids and Surfaces B: Biointerfaces (rok: 2019, tom: 184, strony: 110544), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.colsurfb.2019.110544 - link to the publication
  5. Biocompatible polymers combined with cyclodextrins: Fascinating materials for drug delivery applications
    Authors:
    Bartłomiej Kost , Marek Brzeziński , Marta Socka, Małgorzata Baśko, Tadeusz Biela
    Academic press:
    Molecules (rok: 2020, tom: 25, strony: 3404), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/molecules25153404 - link to the publication
  6. Microfluidics for producing polylactide nanoparticles and microparticles and their drug delivery application
    Authors:
    Marek Brzeziński, Marta Socka, Bartłomiej Kost
    Academic press:
    Polymer International (rok: 2019, tom: 68(6), strony: 997-1014), Wydawca: Wiley
    Status:
    Published
    DOI:
    10.1002/pi.5753 - link to the publication
  7. PLA Stereocomplexed Microspheres Modified with Methyl-β-Cyclodextrin as an Atropine Delivery System. Synthesis and Characterization
    Authors:
    Bartłomiej Kost, Marek Brzezinski, Magdalena Zimnicka, Marta Socka, Ewelina Wielgus, Marta Słowianek, Tadeusz Biela
    Academic press:
    Materials Today Communications (rok: 2020, tom: 25, strony: 101605), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.mtcomm.2020.101605 - link to the publication
  8. Nanocarriers based on block copolymers of L-proline and lactide: The effect of core crosslinking versus its pH-sensitivity on their cellular uptake
    Authors:
    Marek Brzezinski, Bartłomiej Kost, Weronika Gonciarz, Agnieszka Krupa, Marta Socka, Maciej Rogala
    Academic press:
    European Polymer Journal (rok: 2021, tom: 156, strony: 110572), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.eurpolymj.2021.110572 - link to the publication
  9. Nanoparticles from supramolecular polylactides overcome drug resistance of cancer cells
    Authors:
    M.Brzeziński, S.Wedepohl, B.Kost, M.Calderón
    Academic press:
    European Polymer Journal (rok: 2018, tom: 109, strony: 117-123), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.eurpolymj.2018.08.060 - link to the publication
  10. Self-Assembly of Triblock Copolymers from Cyclic Esters as a Tool for Tuning Their Particle Morphology
    Authors:
    M. Socka, M. Brzezinski, A. Michalski, A. Kacprzak, T. Makowski, and A. Duda
    Academic press:
    Langmuir (rok: 2018, tom: 34, strony: 3701-3710), Wydawca: ACS
    Status:
    Published
    DOI:
    10.1021/acs.langmuir.8b00440 - link to the publication
  11. PLA/β-CD-based fibres loaded with quercetin as potential antibacterial dressing materials
    Authors:
    Bartłomiej Kost, Mariia Svyntkivska, Marek Brzezinski, Tomasz Makowski, Ewa Piorkowska, Katarzyna Rajkowska, Alina Kunicka-Styczynska, Tadeusz Biela
    Academic press:
    Colloids and Surfaces B: Biointerfaces (rok: 2020, tom: 190, strony: 110949), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.colsurfb.2020.110949 - link to the publication
  12. Stereocomplexed micelles based on polylactides with β-cyclodextrin core as anti-cancer drug carriers
    Authors:
    B. Kost, M. Brzeziński, M. Cieślak, K. Królewska-Golińska, T. Makowski, M.Socka, T. Biela
    Academic press:
    European Polymer Journal (rok: 2019, tom: 120, strony: 109271), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.eurpolymj.2019.109271 - link to the publication
  13. pH-tunable nanoparticles composed of copolymers of lactide and allyl-glycidyl ether with various functionalities for the efficient delivery of anti-cancer drugs
    Authors:
    B. Kost, W. Gonciarz, A. Krupa, M. Socka, M. Rogala, T. Biela, M. Brzezinski
    Academic press:
    Colloids and Surfaces B: Biointerfaces (rok: 2021, tom: 204, strony: 111801), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.colsurfb.2021.111801 - link to the publication

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