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Hydrogen sulfide as endogenous protective molecule in pathophysiology of Barrett's esophagus development

2016/23/D/NZ4/01913

Keywords

Descriptors

  • NZ4_2: Fizjologia
  • NZ4_4: Patofizjologia ogólna
  • NZ5_3: Patogeneza chorób człowieka

Panel

NZ4 – Biology of tissues, organs and organisms: morphology and functions of animal's and human's systems, organs and organisms, experimental medicine, basics of neurology

Host institution

Uniwersytet Jagielloński- Collegium Medicum, Collegium Medicum; Wydział Lekarski

Voivodeship: małopolskie

Other projects carried out by the institution »

Principal investigator (from the host institution)

dr hab. Marcin Magierowski

Number of co-investigators in the project: 5

Call

SONATA 12 – announced on 2016-09-15

Amount awarded
804 950 PLN
Project start date
2017-07-25
Project end date
2022-07-24
Project duration
60 months (the same as in the proposal)
Project status
Project settled

Project description

Download the project description in a pdf file

Note — project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Czytnik żeli agarozowych.
  2. Komputer przenośny.
  3. System do fluorymetrycznego oznaczenia poziomu wyizolowanych białek, DNA oraz RNA.
  4. Termocykler do przeprowadzenia reakcji real-time PCR.
  5. elektroda do pomiaru gazowych molekuł.
  6. homogenizator do procesowania materiału biologicznego.
  7. odwrócony transmisyjny mikroskop do histologicznych aplikacji z możliwością cyfrowej archiwizacji obrazu. Cost: 75 000 PLN

Information in the final report

Publication in academic press/journals (8)

  1. Emerging role of carbon monoxide in regulation of cellular pathways and in the maintenance of gastric mucosal integrity.

    Authors:
    Magierowska K, Brzozowski T, Magierowski M.*
    Academic press:
    Pharmacological Research (Q1 wg JCR) (year: 2018, volume: 129, pages: 56-64), Publisher: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.phrs.2018.01.008. – link to the publication

  2. Barrett's Metaplasia Progression towards Esophageal Adenocarcinoma: An Attempt to Select a Panel of Molecular Sensors and to Reflect Clinical Alterations by Experimental Models

    Authors:
    Korbut E., Krukowska K., Magierowski M.*
    Academic press:
    International Journal of Molecular Sciences (Q1 wg JCR) (year: 2022, volume: 23(6):3312, pages: 23(6):3312), Publisher: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms23063312. – link to the publication

  3. Interaction of Epidermal Growth Factor With COX-2 Products and Peroxisome Proliferator-Activated Receptor-γ System in Experimental Rat Barrett's Esophagus

    Authors:
    Jolanta Majka, Mateusz Wierdak, Aleksandra Szlachcic, Marcin Magierowski, Aneta Targosz, Katarzyna Urbanczyk, Gracjana Krzysiek-Maczka, Agata Ptak-Belowska, Dominik Bakalarz, Katarzyna Magierowska, Anna Chmura, Tomasz Brzozowski
    Academic press:
    Am J Physiol Gastrointest Liver Physiol (Q1 wg JCR) (year: 2020, volume: 318, pages: G375-G389), Publisher: American Physiological Society
    Status:
    Published
    DOI:
    10.1152/ajpgi.00410.2018 – link to the publication

  4. Synergisms, Discrepancies and Interactions between Hydrogen Sulfide and Carbon Monoxide in the Gastrointestinal and Digestive System Physiology, Pathophysiology and Pharmacology

    Authors:
    Głowacka U., Brzozowski T., Magierowski M.*
    Academic press:
    Biomolecules (year: 2020, volume: 10(3): 445, pages: nie dotyczy), Publisher: MDPI
    Status:
    Published
    DOI:
    10.3390/biom10030445 – link to the publication

  5. Carbon Monoxide Being Hydrogen Sulfide and Nitric Oxide Molecular Sibling, as Endogenous and Exogenous Modulator of Oxidative Stress and Antioxidative Mechanisms in the Digestive System

    Authors:
    Korbut E., Brzozowski T., Magierowski M.*
    Academic press:
    Oxidative Medicine and Cellular Longevity (year: 2020, volume: 2020: 5083876, pages: nie dotyczy), Publisher: Hindawi
    Status:
    Published
    DOI:
    10.1155/2020/5083876 – link to the publication

  6. HOXA13 in etiology and oncogenic potential of Barrett's esophagus.

    Authors:
    Janmaat VT, Nesteruk K, Spaander MCW, Verhaar AP, Yu B, Silva RA, Phillips WA, Magierowski M, van de Winkel A, Stadler HS, Sandoval-Guzmán T, van der Laan LJW, Kuipers EJ, Smits R, Bruno MJ, Fuhler GM, Clemons NJ, Peppelenbosch MP.
    Academic press:
    Nature Communications (Q1 wg JCR) (year: 2021, volume: 12(1), pages: 3354), Publisher: Springer Nature
    Status:
    Published
    DOI:
    10.1038/s41467-021-23641-8 – link to the publication

  7. Molecular Profile of Barrett's Esophagus and Gastroesophageal Reflux Disease in the Development of Translational Physiological and Pharmacological Studies

    Authors:
    Korbut E, Janmaat VT, Wierdak M, Hankus J, Wójcik D, Surmiak M, Magierowska K, Brzozowski T, Peppelenbosch MP, Magierowski M.*
    Academic press:
    International Journal of Molecular Sciences (Q1 wg JCR) (year: 2020, volume: 21 (17), pages: 6436), Publisher: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms21176436 – link to the publication

  8. Melatonin in Prevention of the Sequence from Reflux Esophagitis to Barrett's Esophagus and Esophageal Adenocarcinoma: Experimental and Clinical Perspectives.

    Authors:
    Majka J, Wierdak M, Brzozowska I, Magierowski M, Szlachcic A, Wojcik D, Kwiecien S, Magierowska K, Zagajewski J, Brzozowski T.
    Academic press:
    International Journal of Molecular Sciences (Q1 wg JCR) (year: 2018, volume: 19 (7), pages: 46038), Publisher: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms19072033. – link to the publication

Articles in post-conference publications (14)

  1. Emerging role of hydrogen sulfide in pathophysiology of gastric mucosal injuries

    Authors:
    Magierowska K, Wierdak M, Hubalewska-Mazgaj M, Kwiecien S, Surmiak M, Sliwowski Z, Brzozowski T, Magierowski M
    Conference:
    27th Congress of the Polish Physiological Society (year: 2017, pages: 78), Publisher: Polish Physiological Society
    Date:
    conference 21-22 wrzesień 2017
    Status:
    Published

  2. INHIBITORY EFFECT OF HYDROGEN SULFIDE ON BARRETT'S ESOPHAGUS METAPLASIA DEVELOPMENT

    Authors:
    Wierdak M, Magierowska K, Janmaat V, Hubalewska-Mazgaj M, Chmura A, Bakalarz D, Wojcik D, Smits R, Peppelenbosch M, Brzozowski T, Magierowski M
    Conference:
    26th United European Gastroenterology Week 2018 (year: 2018, pages: A515), Publisher: SAGE Journals
    Date:
    conference 20-24 październik 2018
    Status:
    Published

  3. HYDROGEN SULFIDE (H2S) PREVENTS DEVELOPMENT OF BARRETT'S ESOPHAGUS METAPLASIA

    Authors:
    Magierowski M, Wierdak M, Magierowska K, Janmaat V, Hubalewska-Mazgaj M, Chmura A, Ginter G, Bakalarz D, Brzozowski T
    Conference:
    Digestive Disease Week 2018 (year: 2018, pages: S240), Publisher: Elsevier
    Date:
    conference 02-05 czerwiec 2018
    Status:
    Published

  4. Carbon monoxide (CO) released from its pharmacological donor prevents esophageal mucosa against experimental reflux esophagitis. Possible involvement of annexin 1, prostaglandin E2, endogenous hydrogen sulfide producing enzymes and selected vasoactive mechanisms

    Authors:
    Marcin Magierowski, Dagmara Wójcik, Aleksandra Danielak, Robert Pajdo, Edyta Korbut, Dominik Bakalarz, Zbigniew Sliwowski, Grzegorz Ginter, Anna Chmura, Slawomir Kwiecien, Tomasz Brzozowski
    Conference:
    27th United European Gastroenterology Week 2019 (year: 2019, pages: 417), Publisher: UEG Journal
    Date:
    conference 43759
    Status:
    Published

  5. Expression profile in Barrett's esophagus (BE) observed in humans, surgical animal and in vitro model involving human-derived esophageal cell lines. Molecular markers selection characteristic for clinical BE and reflected in experimental models for further translational pharmacological studies

    Authors:
    Edyta Korbut, Dagmara Wójcik, Mateusz Wierdak, Dominik Bakalarz, Vincent Janmaat, Tomasz Brzozowski, Marcin Magierowski
    Conference:
    27th United European Gastroenterology Week 2019 (year: 2019, pages: 429-430), Publisher: UEG Journal
    Date:
    conference 43759
    Status:
    Published

  6. Gaseous mediators in gastrointestinal physiology, pathophysiology and pharmacology

    Authors:
    Dominik Bakalarz, Dagmara Wójcik, Katarzyna Magierowska, Edyta Korbut, Aleksandra Danielak, Vincent Janmaat, Grzegorz Ginter, Mateusz Wierdak, Sławomir Kwiecień, Zbigniew Śliwowski, Tomasz Brzozowski, Marcin Magierowski
    Conference:
    Federation of European Physiological Societies (FEPS) and the Italian Physiological Society (SIF) Conference (year: 2019, pages: 144), Publisher: Acta Physiologica
    Date:
    conference 43718
    Status:
    Published

  7. POSSIBLE INVOLVEMENT OF HYDROGEN SULFIDE (H2S) IN PREVENTION OF BARRETT'S ESOPHAGUS DEVELOPMENT

    Authors:
    Wierdak M, Magierowska K, Hubalewska-Mazgaj M, Janmaat V, Ginter G, Chmura A, Bakalarz D, Brzozowski T, Magierowski M
    Conference:
    5th World Congress on Hydrogen Sulfide in Biology and Medicine (year: 2018, pages: brak), Publisher: brak
    Date:
    conference 31.05-03.06.2018
    Status:
    Published

  8. Emerging role of hydrogen sulfide (H2S) in pathophysiology and pharmacology of gastrointestinal disorders

    Authors:
    Aleksandra Danielak, Dagmara Wójcik, Edyta Korbut, Dominik Bakalarz, Katarzyna Magierowska, Vincent Janmaat, Grzegorz Ginter, Mateusz Wierdak, Tomasz Brzozowski, Marcin Magierowski
    Conference:
    The FEBS Congress 2019 (year: 2019, pages: 27), Publisher: FEBS Open Bio
    Date:
    conference 43652
    Status:
    Published

  9. INHIBITORY EFFECT OF SLOW H2S-RELEASING DONOR (GYY4137) ON THE DEVELOPMENT OF BARRETT'S METAPLASIA-SPECIFIC MOLECULAR PROFILE AND INFLAMMATORY SIGNALING

    Authors:
    E. Korbut, D. Wójcik, K. Magierowska, V.T. Janmaat, M. Wierdak, M. Szetela, T. Brzozowski, M. Whiteman, M. Magierowski
    Conference:
    United European Gastroenterology Week 2021 (year: 2021, pages: 171-172), Publisher: UEG Journal (Wiley)
    Date:
    conference 03-05.10.2021
    Status:
    Published
    DOI:
    link to the publication

  10. GASEOUS MEDIATORS‐RELEASING PRODRUGS VS ACUTE AND CHRONIC PATHOLOGIES OF UPPER GASTROINTESTINAL TRACT

    Authors:
    Katarzyna Magierowska, Edyta Korbut, Dagmara Wójcik‐Grzybek, Kinga Krukowska, Urszula Głowacka, Dominik Bakalarz, Tomasz Brzozowski, John L Wallace, Binghe Wang, Matthew Whiteman, Marcin Magierowski*
    Conference:
    Hungarian Society for Experimental and Clinical Pharmacology (Annual Congress, 2022) (year: 2022, pages: 69), Publisher: Hungarian Society for Experimental and Clinical Pharmacology
    Date:
    conference 7-9 czerwiec
    Status:
    Published

  11. THE INTERPLAY BETWEEN ENDOGENOUS GASEOUS MEDIATORS, CARBON MONOXIDE AND HYDROGEN SULFIDE IN PHYSIOLOGY AND PATHOPHYSIOLOGY OF GASTROINTESTINAL TRACT

    Authors:
    Marcin Magierowski
    Conference:
    28th CONGRESS OF THE POLISH PHYSIOLOGICAL SOCIETY (year: 2021, pages: 147), Publisher: The Polish Physiological Society
    Date:
    conference 15-17.09.2021
    Status:
    Published
    DOI:
    link to the publication

  12. DECREASED ACTIVITY OF ENDOGENOUS HYDROGEN SULFIDE (H2S)- PRODUCING ENZYME IN BARRETT'S METAPLASIA PROGRESSION WITH POSSIBLE MODULATION OF METALLOPEPTIDASE INHIBITOR (TIMP1) AND SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3 (STAT3) PATHWAYS

    Authors:
    Edyta Korbut, Urszula Glowacka, Mateusz Wierdak, Dagmara Wójcik, Jerzy Hankus, Katarzyna Magierowska, Tomasz Brzozowski, Vincent Janmaat, Marcin Magierowski
    Conference:
    Digestive Disease Week 2021 (year: 2021, pages: S-241), Publisher: Elsevier
    Date:
    conference 21-23.05.2021
    Status:
    Published

  13. CONTRIBUTION OF HYDROGEN SULFIDE-PRODUCING CYSTATHIONINE-G-LYASE (CTH) IN THE DEVELOPMENT OF BARRETT'S METAPLASIA-SPECIFIC MOLECULAR PROFILE AND SYSTEMIC INFLAMMATION

    Authors:
    Korbut E., Wierdak M., Magierowska K., Glowacka U., Wójcik D., Brzozowski T., Surmiak M., Janmaat V.T., Peppelenbosch M.P., Smits R., Magierowski M.
    Conference:
    United European Gastroenterology Week 2020 (year: 2020, pages: s. 202: P0131), Publisher: UEG Journal
    Date:
    conference 11-13 październik 2020
    Status:
    Published

  14. THE EFFECT OF INCREASED AND DECREASED H2S BIOAVAILABILITY ON THE DEVELOPMENT OF BARRETT'S METAPLASIA

    Authors:
    E. KORBUT, D. WOJCIK, K. MAGIEROWSKA, V. JANMAAT, M. WIERDAK, T. BRZOZOWSKI, M. SZETELA, M. WHITEMAN, M. MAGIEROWSKI
    Conference:
    28th CONGRESS OF THE POLISH PHYSIOLOGICAL SOCIETY (year: 2021, pages: 151), Publisher: The Polish Physiological Society
    Date:
    conference 15-17.09.2021
    Status:
    Published
    DOI:
    link to the publication

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Graphic design and implementation: Jakub Piotrowski