Derivatives of aromatic polyene macrolides of improved selective toxicity

2016/23/B/NZ7/01223

Keywords

Descriptors

NZ7_14: Farmacja, farmakoterapia, farmakologia
NZ6_7: Mykologia

Panel

NZ7 – Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution

Politechnika Gdańska, Wydział Chemiczny

Voivodeship: pomorskie

Other projects carried out by the institution »

Principal investigator (from the host institution)

prof. Sławomir Piotr Milewski

Number of co-investigators in the project: 8

Call

OPUS 12 – announced on 2016-09-15

Amount awarded: 943 050 PLN
Project start date: 2017-07-04
Project end date: 2021-07-03
Project duration: 48 months (the same as in the proposal)
Project status: Project settled

Project description

Download the project description in a pdf file

Note — project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

Chromatograf przeciwprądowy pola odśrodkowego. Cost: 445 000 PLN
Źródło światła monochromatycznego. Cost: 45 000 PLN

Information in the final report

Publication in academic press/journals (5)

Quest for the molecular basis of improved selective toxicity of all-trans isomers of aromatic heptaene macrolide antifungal antibiotics

Authors:
Julia Borzyszkowska-Bukowska, Justyna Górska, Paweł Szczeblewski, Tomasz Laskowski, Piotr Szweda, Iwona Gabriel, Jakub Jurasz, Katarzyna Kozłowska-Tylingo, Sławomir Milewski

Academic press:
International Journal of Molecular Sciences (year: 2021, volume: 22, pages: 10108), Publisher: MDPI

Status:
Published

DOI:
10.3390/ijms221810108 – link to the publication
Isopartricin - an aromatic analogue of Amphotericin B. An old drug in a new light, which causes a structural changes

Authors:
Paweł Szczeblewski, Justyna Górska, Witold Andrałojć, Patryk Janke, Karolina Wąsik, Tomasz Laskowski

Academic press:
Antibiotics (year: 2021, volume: 10, pages: 1102), Publisher: MDPI

Status:
Published

DOI:
10.3390/antibiotics10091102 – link to the publication
The complete stereochemistry of the antibiotic candicidin A3 (syn. ascosin A3, levorin A3)

Authors:
Julia Borzyszkowska-Bukowska, Paweł Szczeblewski, Agnieszka Konkol, Jakub Grynda, Katarzyna Szwarc-Karabyka, Tomasz Laskowski

Academic press:
Natural Products Research (year: 2020, volume: 34, pages: 2869-2879), Publisher: Taylor & Francis

Status:
Published

DOI:
10.1080/14786419.2019.1596095 – link to the publication
Light-Induced Transformation of the Aromatic Heptaene Antifungal Antibiotic Candicidin D into Its All-Trans Isomer

Authors:
Paweł Szczeblewski, Tomasz Laskowski, Aleksandra Bałka, Edward Borowski, Sławomir Milewski

Academic press:
Journal of Natural Products (year: 2018, volume: 81, pages: 1540-1545), Publisher: ACS Publications

Status:
Published

DOI:
10.1021/acs.jnatprod.7b00821 – link to the publication
Ipertrofan revisited - the complete stereochemistry of mepartrcin A and B

Authors:
Paweł Szczeblewski, Witold Andrałojć, Justyna Polit, Aneta Żabka, Konrad Winnicki, Tomasz Laskowski

Academic press:
Molecules (year: 2021, volume: 26, pages: 5533), Publisher: MDPI

Status:
Published

DOI:
10.3390/molecules26185533 – link to the publication

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