Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Synergistic mechanisms of heme acquisition used by periodontopathogens under physiological conditions and in periodontal diseases associated with systemic diseases

2016/23/B/NZ6/00080

Keywords:

Porphyromonas gingivalis periodontopathogens heme periodontal diseases diabetes systemic diseases

Descriptors:

  • NZ6_4: Bacteriology
  • NZ1_10: Microbiology
  • NZ6_8: Other related subjects

Panel:

NZ6 - Human and animal immunology and infection: immunity, immune disorders, immunotherapy, infectious and invasive diseases, microbiology, transplantology, allergology

Host institution :

Uniwersytet Wrocławski, Wydział Biotechnologii

woj. dolnośląskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Teresa Olczak 

Number of co-investigators in the project: 6

Call: OPUS 12 - announced on 2016-09-15

Amount awarded: 845 800 PLN

Project start date (Y-m-d): 2017-07-27

Project end date (Y-m-d): 2021-07-26

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Inkubator do hodowli bakterii z wytrząsaniem i chłodzeniem (45 000 PLN)

Information in the final report

  • Publication in academic press/journals (4)
  1. Virulence mechanisms used in pathogenesis of periodontal diseases caused by Porphyromonas gingivalis
    Authors:
    Smiga M, Ślęzak P, Siemińska K, Olczak T
    Academic press:
    Postepy Higieny i Medycyny Doświadczalnej (rok: 2020, tom: 74, strony: 247-259), Wydawca: Index Copernicus International
    Status:
    Published
    DOI:
    10.5604/01.3001.0014.3053 - link to the publication
  2. Porphyromonas gingivalis HmuY and Streptococcus gordonii GAPDH - novel heme acquisition strategy in the oral microbiome
    Authors:
    Ślęzak P, Śmiga M, Smalley JW, Siemińska K, Olczak T
    Academic press:
    International Journal of Molecular Sciences (rok: 2020, tom: 21, strony: 4150), Wydawca: MDPI
    Status:
    Published
    DOI:
    103390/ijms21114150 - link to the publication
  3. Glycation of host proteins increases pathogenic potential of Porphyromonas gingivalis
    Authors:
    Śmiga M, Smalley J.W., Ślęzak P, Brown JL, Siemińska K, Jenkins RE, Yates EA, Olczak T
    Academic press:
    International Journal of Molecular Sciences (rok: 2021, tom: 22, strony: 12084), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms222112084 - link to the publication
  4. Potential role for Streptococcus gordonii-derived hydrogen peroxide in haem acquisition by Porphyromonas gingivalis.
    Authors:
    Brown JL, Yates E, Bielecki M, Olczak T, Smalley JW
    Academic press:
    Molecular Oral Microbiology (rok: 2018, tom: 33, strony: 322-335), Wydawca: Wiley
    Status:
    Published
    DOI:
    10.1111/omi.12229 - link to the publication

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