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Information on the principal investigator and host institution

Information of the project and the call

Keywords

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Fluorogenic and luminogenic probes for in vivo imaging of peroxynitrite - from synthesis to footprint detection

2016/22/E/ST4/00549

Keywords:

bioluminescent and fluorescent imaging reactive oxygen and nitrogen species peroxynitrite,probes

Descriptors:

  • ST4_6: Instrumental methods in chemistry
  • NZ3_14: Other related subjects
  • ST5_25:

Panel:

ST4 - Chemistry: physical chemistry/chemical physics, theoretical chemistry, analytical chemistry, inorganic chemistry, organic chemistry, method development

Host institution :

Politechnika Łódzka, Wydział Chemiczny

woj. łódzkie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Radosław Podsiadły 

Number of co-investigators in the project: 5

Call: SONATA BIS 6 - announced on 2016-06-15

Amount awarded: 1 897 000 PLN

Project start date (Y-m-d): 2017-03-27

Project end date (Y-m-d): 2023-03-26

Project duration:: 72 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Układ HPLC z detektorem absorpcyjnym i fluorescencyjnym (350 000 PLN)

Information in the final report

  • Publication in academic press/journals (12)
  • Book publications / chapters in book publications (1)
  1. Boronate-based probes for biological oxidants: A novel class of molecular tools for redox biology
    Authors:
    Adam Sikora, Jacek Zielonka, Karolina Dębowska, Radosław Michalski, Renata Smulik-Izydorczyk, Jakub Pięta, Radosław Podsiadły, Angelika Artelska, Karolina Pierzchała, Balaraman Kalyanaraman
    Academic press:
    Frontiers in Chemistry (rok: 2020, tom: 8, strony: 580899), Wydawca: Frontiers
    Status:
    Published
    DOI:
    10.3389/fchem.2020.580899 - link to the publication
  2. Increased formation of reactive oxygen species during tumor growth: Ex vivo low-temperature EPR and in vivo bioluminescence analyses
    Authors:
    G. Cheng, J. Pan, R. Podsiadly, J. Zielonka, A. M. Garces, L. G. D. D. Machado, B. Bennett, D. McAllister, M. B. Dwinell, M. You, B. Kalyanaraman
    Academic press:
    Free Radical Biology and Medicine (rok: 2020, tom: 147, strony: 167-174), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.freeradbiomed.2019.12.020 - link to the publication
  3. On the chemical reactivity of tricyanofuran(TCF)-based near-infrared fluorescent redox probes – Effects of glutathione on the probe response and product fluorescence
    Authors:
    P. Siarkiewicz, R. Michalski, A. Sikora, R. Smulik-Izydorczyk, M. Szala, A. Grzelakowska, J. Modrzejewska, A. Bailey, J. E. Nycz, B. Kalyanaraman, J. G. Malecki, J. Zielonka, R. Podsiadły
    Academic press:
    Dyes and Pigments (rok: 2021, tom: 192, strony: 109405), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.dyepig.2021.109405 - link to the publication
  4. Fluorescent probes for monitoring myeloperoxidase‑derived hypochlorous acid: a comparative study
    Authors:
    K. Pierzchała, M. Pięta, M. Rola, M. Świerczyńska, A. Artelska, K. Dębowska, R. Podsiadły, J. Pięta, J. Zielonka, A. Sikora, A. Marcinek, R. Michalski
    Academic press:
    Scientific Reports (rok: 2022, tom: 12, strony: 45305), Wydawca: Springer Nature
    Status:
    Published
    DOI:
    10.1038/s41598-022-13317-8 - link to the publication
  5. Selective, stoichiometric and fast-response fluorescent probe based on 7-nitrobenz-2-oxa-1,3-diazole fluorophore for hypochlorous acid detection
    Authors:
    M. Świerczyńska, D. Słowiński, A. Grzelakowska, M. Szala, J. Romański, K. Pierzchała, P. Siarkiewicz, R. Michalski, R. Podsiadły
    Academic press:
    Dyes and Pigments (rok: 2021, tom: 192, strony: 109563), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.dyepig.2021.109563 - link to the publication
  6. Pro-luciferin probes containing (2-diphenylphosphino)benzoate and 2-thiolo-2-methylpropionate moieties: Synthesis, characterization, and reactivity toward nitroxyl
    Authors:
    M. Szala, J. Modrzejewska, A. Grzelakowska, J. Kolińska, R. Michalski, A. Artelska, A. Sikora, R. Podsiadły
    Academic press:
    Dyes and Pigments (rok: 2023, tom: 210, strony: 110996), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.dyepig.2022.110996 - link to the publication
  7. Two-photon fluorescent probe for cellular peroxynitrite: Fluorescence detection, imaging, and identification of peroxynitrite-specific products
    Authors:
    A. Grzelakowska, M. Zielonka, K. Dębowska, J. Modrzejewska, M. Szala, A. Sikora, J. Zielonka, R. Podsiadły
    Academic press:
    Free Radical Biology and Medicine (rok: 2021, tom: 169, strony: 24-35), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.freeradbiomed.2021.04.011 - link to the publication
  8. Water-soluble cationic boronate probe based on coumarin imidazolium scaffold: Synthesis, characterization, and application to cellular peroxynitrite detection
    Authors:
    A. Grzelakowska, J. Modrzejewska, J. Kolińska, M. Szala, M. Zielonka, K. Dębowska, M. Zakłos-Szyda, A. Sikora, J. Zielonka, R. Podsiadły
    Academic press:
    Free Radical Biology and Medicine (rok: 2022, tom: 179, strony: 34-46), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.freeradbiomed.2021.12.260 - link to the publication
  9. Water-soluble cationic boronate probe based on coumarin imidazolium scaffold: Synthesis, characterization, and application to cellular peroxynitrite detection
    Authors:
    A. Grzelakowska, J. Modrzejewska, J. Kolińska, M. Szala, M. Zielonka, K. Dębowska, M. Zakłos-Szyda, A. Sikora, J. Zielonka, R. Podsiadły
    Academic press:
    Free Radical Biology and Medicine (rok: 2022, tom: 179, strony: 34-46), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.freeradbiomed.2021.12.260 - link to the publication
  10. Novel boronate probe based on 3-benzothiazol-2-yl-7-hydroxy-chromen-2-one for detection of peroxynitrite and hypochlorite
    Authors:
    J. Modrzejewska, M. Szala, A. Grzelakowska, M. Zakłos-Szyda, J. Zielonka, R. Podsiadły
    Academic press:
    Molecules (rok: 2021, tom: 26, strony: 5940), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ - link to the publication
  11. Recent progress in the synthesis of firefly luciferin derivatives
    Authors:
    R. Podsiadły, A. Grzelakowska, J. Modrzejewska, P. Siarkiewicz, D. Słowiński, M. Szala, M. Świerczyńśka
    Academic press:
    Dyes and Pigments (rok: 2019, tom: 170, strony: 107627), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.dyepig.2019.107627 - link to the publication
  12. Characterization of the reactivity of luciferin boronate - A probe for inflammatory oxidants with improved stability
    Authors:
    Marcin Szala, Aleksandra Grzelakowska, Julia Modrzejewska, Przemysław Siarkiewicz, Daniel Słowiński, Małgorzata Świerczyńska, Jacek Zielonka, Radosław Podsiadły
    Academic press:
    Dyes and Pigments (rok: 2020, tom: 183, strony: 108693), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.dyepig.2020.108693 - link to the publication
  1. Identification of peroxynitrite by profiling oxidation and nitration products from mitochondria-targeted arylboronic acid
    Authors:
    J. Zielonka, A. Sikora, R. Podsiadly, M. Hardy, B. Kalyanaraman
    Book:
    Mitochondrial Medicine: Volume 1: Targeting Mitochondria (rok: 2021, tom: 1, strony: 315-327), Wydawca: Springer Nature
    Status:
    Published

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