Self-association of cholesterol molecules near the mambrane oversaturated with cholesterol modelling initial stages of processes leading to atherosclerotic plaque formation: computer simulation and experiment
2016/22/M/NZ1/00187
Keywords
Descriptors
- NZ1_3: Biofizyka
- NZ2_10: Modelowanie i symulacje biologiczne
Panel
NZ1 – Molecular biology, structural biology, biotechnology: molecular biology, structural biology, biotechnology
Host institution
Uniwersytet Jagielloński, Wydział Biochemii, Biofizyki i Biotechnologii
Voivodeship: małopolskie
Principal investigator (from the host institution)
prof. Marta Pasenkiewicz-Gierula
Number of co-investigators in the project: 5
Call
HARMONIA 8 – announced on 2016-06-15
- Amount awarded
- 351 884 PLN
- Project start date
- 2017-04-14
- Project end date
- 2021-10-13
- Project duration
- 54 months (the same as in the proposal)
- Project status
- Project settled
Project description
Download the project description in a pdf file
Note — project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.
Information in the final report
Publication in academic press/journals (5)
-
Effect of Electrical Parameters and Cholesterol Concentration on Giant Unilamellar Vesicles Electroformation
- Authors:
- Z. Boban, A. Puljas, D. Kovač, W. K. Subczynski, M. Raguz
- Academic press:
- Cell Biochemistry and Biophysics (year: 2020, volume: 78, pages: 157–164), Publisher: Springer
- Status:
- Published
- DOI:
- 10.1007/s12013-020-00910-9 – link to the publication
-
Chirality affects cholesterol-oxysterol association in water, a computational study
- Authors:
- M. Markiewicz*, R. Szczelina, B. Milanovic, W. K. Subczynski, M. Pasenkiewicz-Gierula*
- Academic press:
- Computational and Structural Biotechnology Journal (year: 2021, volume: 19, pages: 4319-4335), Publisher: Elsevier
- Status:
- Published
- DOI:
- 10.1016/j.csbj.2021.07.022 – link to the publication
-
Formation of cholesterol bilayer domains precedes formation of cholesterol crystals in membranes made of the major phospholipids of human eye lens fiber cell plasma membranes.
- Authors:
- L. Mainali, M. Pasenkiewicz-Gierula, W. K. Subczynski
- Academic press:
- Current Eye Research (year: 2020, volume: 45, pages: 162–172), Publisher: Taylor & Francis Group
- Status:
- Published
- DOI:
- 10.1080/02713683.2019.1662058 – link to the publication
-
Hypothetical pathway for formation of cholesterol microcrystals initiating the atherosclerotic process
- Authors:
- W. K. Subczynski, M. Pasenkiewicz-Gierula
- Academic press:
- Cell Biochemistry and Biophysics (year: 2020, volume: 78, pages: 241–247), Publisher: Springer
- Status:
- Published
- DOI:
- 10.1007/s12013-020-00925-2 – link to the publication
-
Data for molecular dynamic simulations in the OPLSAA force field: Partial charges of cholesterol, C7-hydroxycholesterol and C7-hydroperoxycholesterol, torsional parameters for the hydroperoxy group of C7-hydroperoxycholesterol
- Authors:
- M. Markiewicz*, R. Szczelina, M. Pasenkiewicz-Gierula
- Academic press:
- Data in Brief (year: 2021, volume: 39, pages: 107483), Publisher: Elsevier
- Status:
- Published
- DOI:
- 10.1016/j.csbj.2021.07.022 – link to the publication
Book publications / chapters in book publications (2)
-
Role of cholesterol in maintaining the physical properties of the plasma membrane
- Authors:
- W. K. Subczynski, M. Pasenkiewicz-Gierula, J. Widomska, N. Stein
- Book:
- Cholesterol: from biophysics to the clinics (year: 2022, volume: -, pages: 41-71), Publisher: Academic Press is an imprint of Elsevier
- Status:
- Published
-
Computer Modelling of the Lipid Matrix of Biomembranes
- Authors:
- Marta Pasenkiewicz-Gierula, Michał Markiewicz
- Book:
- Computational Methods to Study the Structure and Dynamics of Biomolecules and Biomolecular Processes (year: 2019, volume: 8, pages: 331-370), Publisher: Springer
- Status:
- Published