Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Nanoencapsulated Photosensitizing Drugs for Photodynamic Therapy of Resistant Cancers and Microbes

2016/22/E/NZ7/00420

Keywords:

drug resistance photodynamic therapy photodynamic inactivation of microorganisms photosensitizer bacteriochlorins phthalocyanines

Descriptors:

  • NZ7_14:
  • NZ7_15:
  • ST4_17:

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Uniwersytet Jagielloński, Wydział Chemii

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Janusz Marcin Dąbrowski 

Number of co-investigators in the project: 12

Call: SONATA BIS 6 - announced on 2016-06-15

Amount awarded: 1 999 880 PLN

Project start date (Y-m-d): 2017-04-07

Project end date (Y-m-d): 2024-04-06

Project duration:: 84 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (25)
  • Book publications / chapters in book publications (4)
  1. Sensitization of TiO2 by halogenated porphyrin derivatives for visible light biomedical and environmental photocatalysis
    Authors:
    A. Sułek, B. Pucelik, J. Kuncewicz, G. Dubin, J. M. Dąbrowski
    Academic press:
    Catalysis Today (rok: 2019, tom: 335, strony: 538-549), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.cattod.2019.02.070 - link to the publication
  2. Effects of Photodynamic Therapy with Redaporfin on Tumor Oxygenation and Blood Flow in a Lung Cancer Mouse Model
    Authors:
    Malwina Karwicka, Barbara Pucelik, Michał Gonet, Martyna Elas, Janusz M Dąbrowski
    Academic press:
    Scientific Reports (rok: 2019, tom: 9, strony: 45672), Wydawca: Nature Research
    Status:
    Published
    DOI:
    10.1038/s41598-019-49064-6 - link to the publication
  3. Properties of halogenated and sulfonated porphyrins relevant for the selection of photosensitizers in anticancer and antimicrobial therapies
    Authors:
    Barbara Pucelik, Robert Paczyński, Grzegorz Dubin, Mariette M. Pereira, Luis G. Arnaut, Janusz M. Dąbrowski
    Academic press:
    PlosONE (rok: 2017, tom: 2017, strony: 45679), Wydawca: Plos
    Status:
    Published
    DOI:
    10.1371/journal.pone.0185984 - link to the publication
  4. Dihydroxyanthraquinones as stable and cost-effective TiO2 photosensitizers for environmental and biomedical applications
    Authors:
    Mateusz Trochowski, Marcin Kobielusz, Barbara Pucelik, Janusz M. Dąbrowski, Wojciech Macyk
    Academic press:
    Journal of Photochemistry & Photobiology, A: Chemistry (rok: 2023, tom: 438, strony: 114517), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.jphotochem.2022.114517 - link to the publication
  5. Bacteriochlorins and their metal complexes as NIR-absorbing photosensitizers: Properties, mechanisms, and applications
    Authors:
    Barbara Pucelik, Adam Sułek, Janusz M. Dąbrowski
    Academic press:
    Coord. Chem. Rev. (rok: 2020, tom: 416, strony: 213340), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.ccr.2020.213340 - link to the publication
  6. Enhancing Visible-Light Photocatalysis with Pd(II) Porphyrin-Based TiO2 Hybrid Nanomaterials: Preparation, Characterization, ROS Generation, and Photocatalytic Activity
    Authors:
    Dawid Malec, Marta Warszynska, Paweł Repetowski, Anton Siomchen, Janusz M. Dabrowski
    Academic press:
    Molecules (rok: 2023, tom: 28, strony: 7819), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/molecules28237819 - link to the publication
  7. Photodynamic inactivation of E. coli with cationic imidazolyl‑porphyrin photosensitizers and their synergic combination with antimicrobial cinnamaldehyde
    Authors:
    Madalena F. C. Silva, Rafael T. Aroso, Janusz M. Dabrowski, Barbara Pucelik, Agata Barzowska, Gabriela J. da Silva, Luis G. Arnaut, Mariette M. Pereira
    Academic press:
    Photochemical & Photobiological Sciences (rok: 2024, tom: 23, strony: 1129–1142), Wydawca: Springer Nature
    Status:
    Published
    DOI:
    10.1007/s43630-024-00581-y - link to the publication
  8. Lipophilicity of Bacteriochlorin-Based Photosensitizers as a Determinant for PDT Optimization through the Modulation of the Inflammatory Mediators
    Authors:
    Barbara Pucelik, Luis G Arnaut, Janusz M Dąbrowski
    Academic press:
    Journal of Clinical Medicine (rok: 2020, tom: 9, strony: 8), Wydawca: Multidisciplinary Digital Publishing Institute
    Status:
    Published
    DOI:
    10.3390/jcm9010008 - link to the publication
  9. Synthesis and Characterization of Size- and Charge-Tunable Silver Nanoparticles for Selective Anticancer and Antibacterial Treatment
    Authors:
    Barbara Pucelik, Adam Sułek, Mariusz Borkowski, Agata Barzowska, Marcin Kobielusz, Janusz M. Dąbrowski
    Academic press:
    ACS Appl. Mater. Interfaces 2022, (rok: 2022, tom: 14, strony: 14981−14996), Wydawca: American Chemical Society
    Status:
    Published
    DOI:
    10.1021/acsami.2c01100 - link to the publication
  10. Surface Modification of Nanocrystalline TiO2 Materials with Sulfonated Porphyrins for Visible Light Antimicrobial Therapy
    Authors:
    Adam Sułek, Barbara Pucelik, Marcin Kobielusz, Przemysław Łabuz, Grzegorz Dubin, Janusz M Dąbrowski
    Academic press:
    Catalysts (rok: 2019, tom: 9, strony: 821), Wydawca: Multidisciplinary Digital Publishing Institute
    Status:
    Published
    DOI:
    10.3390/catal9100821 - link to the publication
  11. Photodynamic therapy as an alternative to antibiotic therapy for the treatment of infected leg ulcers
    Authors:
    Aleksandra Kawczyk-Krupka ,Barbara Pucelik , Anna Międzybrodzka , Aleksander R. Sieroń, Janusz M. Dąbrowski
    Academic press:
    Photodiagnosis and Photodynamic Therapy (rok: 2018, tom: 23, strony: 132-143), Wydawca: ELSEVIER
    Status:
    Published
    DOI:
    10.1016/j.pdpdt.2018.05.001 - link to the publication
  12. Translating phototherapeutic indices from in vitro to in vivo photodynamic therapy with bacteriochlorins
    Authors:
    André F.S Luz, BarbaraPucelik, Mariette M. Pereira,Janusz Dąbrowski, Luis G.Arnaut
    Academic press:
    Lasers in Surgery and Medicine (rok: 2018, tom: 50, strony: 451-459), Wydawca: WILEY
    Status:
    Published
    DOI:
    10.1002/lsm.22931 - link to the publication
  13. Synthesis and Characterization of Size- and Charge-Tunable Silver Nanoparticles for Selective Anticancer and Antibacterial Treatment
    Authors:
    Barbara Pucelik, Adam Sułek, Mariusz Borkowski, Agata Barzowska, Marcin Kobielusz, Janusz M. Dąbrowski
    Academic press:
    ACS Appl. Mater. Interfaces 2022, (rok: 2022, tom: 14, strony: 14981−14996), Wydawca: American Chemical Society
    Status:
    Published
    DOI:
    10.1021/acsami.2c01100 - link to the publication
  14. Recent advances in strategies for overcoming hypoxia in photodynamic therapy of cancer
    Authors:
    Barbara Pucelik, Adam Sułek, Agata Barzowska, Janusz M. Dąbrowski
    Academic press:
    Cancer Lett. (rok: 2020, tom: 492, strony: 116–135), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.canlet.2020.07.007 - link to the publication
  15. Refining antimicrobial photodynamic therapy: effect of charge distribution and central metal ion in fluorinated porphyrins on effective control of planktonic and biofilm bacterial forms
    Authors:
    Barbara Pucelik, Agata Barzowska, Adam Sulek, Mateusz Werlos, Janusz M. Dabrowski
    Academic press:
    Photochemical & Photobiological Sciences (rok: 2024, tom: 23, strony: 539–560), Wydawca: Springer Nature
    Status:
    Published
    DOI:
    10.1007/s43630-024-00538-1 - link to the publication
  16. Photodynamic inactivation of E. coli with cationic imidazolyl‑porphyrin photosensitizers and their synergic combination with antimicrobial cinnamaldehyde
    Authors:
    Madalena F. C. Silva, Rafael T. Aroso, Janusz M. Dabrowski, Barbara Pucelik, Agata Barzowska, Gabriela J. da Silva, Luis G. Arnaut, Mariette M. Pereira
    Academic press:
    Photochemical & Photobiological Sciences (rok: 2024, tom: 23, strony: 1129–1142), Wydawca: Springer Nature
    Status:
    Published
    DOI:
    10.1007/s43630-024-00581-y - link to the publication
  17. Translating phototherapeutic indices from in vitro to in vivo photodynamic therapy with bacteriochlorins
    Authors:
    André F.S Luz, BarbaraPucelik, Mariette M. Pereira,Janusz Dąbrowski, Luis G.Arnaut
    Academic press:
    Lasers in Surgery and Medicine (rok: 2018, tom: 50, strony: 451-459), Wydawca: WILEY
    Status:
    Published
    DOI:
    10.1002/lsm.22931 - link to the publication
  18. Recent advances in strategies for overcoming hypoxia in photodynamic therapy of cancer
    Authors:
    Barbara Pucelik, Adam Sułek, Agata Barzowska, Janusz M. Dąbrowski
    Academic press:
    Cancer Lett. (rok: 2020, tom: 492, strony: 116–135), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.canlet.2020.07.007 - link to the publication
  19. Enhanced Cellular Uptake and Photodynamic Effect with Amphiphilic Fluorinated Porphyrins: The Role of Sulfoester Groups and the Nature of Reactive Oxygen Species
    Authors:
    B. Pucelik, A. Sułek, A. Drozd, G. Stochel, M. M. Pereira, S. Pinto, L. G. Arnaut, J. M. Dąbrowski
    Academic press:
    Int. J. Mol. Sci. (rok: 2020, tom: 21, strony: 2786), Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
    Status:
    Published
    DOI:
    10.3390/ijms21082786 - link to the publication
  20. Perspectives of molecular and nanostructured systems with d-and f-block metals in photogeneration of reactive oxygen species for medical strategies
    Authors:
    Joanna Kuncewicz, Janusz M Dąbrowski, Agnieszka Kyzioł, Małgorzata Brindell, Przemysław Łabuz, Olga Mazuryk, Wojciech Macyk, Grażyna Stochel
    Academic press:
    Coordination Chemistry Reviews (rok: 2019, tom: 398, strony: 113012), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.ccr.2019.07.009 - link to the publication
  21. Bioinorganic antimicrobial strategies in the resistance era
    Authors:
    A. Regiel-Futyra, J.M.Dąbrowski, O. Mazuryk, K. Śpiewak, A. Kyzioł, B. Pucelik. M. Brindell, G. Stochel
    Academic press:
    Coordination Chemistry Reviews (rok: 2017, tom: 351, strony: 76-117), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.ccr.2017.05.005 - link to the publication
  22. Photoinactivation of microorganisms with sub-micromolar concentrations of imidazolium metallophthalocyanine salts
    Authors:
    Rafael T Aroso, Mário JF Calvete, Barbara Pucelik, Grzegorz Dubin, Luis G Arnaut, Mariette M Pereira, Janusz M Dąbrowski
    Academic press:
    European Journal of Medicinal Chemistry (rok: 2019, tom: 184, strony: 111740), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.ejmech.2019.111740 - link to the publication
  23. Photodynamic Inactivation of Bacteria with Porphyrin Derivatives: Effect of Charge, Lipophilicity, ROS Generation, and Cellular Uptake on Their Biological Activity In Vitro
    Authors:
    Adam Sułek, Barbara Pucelik, Marcin Kobielusz. Agata Barzowska, Janusz M. Dąbrowski
    Academic press:
    Int. J. Mol. Sci. (rok: 2020, tom: 21, strony: 8716), Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
    Status:
    Published
    DOI:
    10.3390/ijms21228716 - link to the publication
  24. Enhanced Cellular Uptake and Photodynamic Effect with Amphiphilic Fluorinated Porphyrins: The Role of Sulfoester Groups and the Nature of Reactive Oxygen Species
    Authors:
    B. Pucelik, A. Sułek, A. Drozd, G. Stochel, M. M. Pereira, S. Pinto, L. G. Arnaut, J. M. Dąbrowski
    Academic press:
    Int. J. Mol. Sci. (rok: 2020, tom: 21, strony: 2786), Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
    Status:
    Published
    DOI:
    10.3390/ijms21082786 - link to the publication
  25. Photodynamic therapy as an alternative to antibiotic therapy for the treatment of infected leg ulcers
    Authors:
    Aleksandra Kawczyk-Krupka ,Barbara Pucelik , Anna Międzybrodzka , Aleksander R. Sieroń, Janusz M. Dąbrowski
    Academic press:
    Photodiagnosis and Photodynamic Therapy (rok: 2018, tom: 23, strony: 132-143), Wydawca: ELSEVIER
    Status:
    Published
    DOI:
    10.1016/j.pdpdt.2018.05.001 - link to the publication
  1. Rozwój nowoczesnych metod terapeutycznych w leczeniu czerniaka - mechanizmy molekularne i zastosowanie kliniczne
    Authors:
    G. Gawlik, B. Pucelik, A. Kłóś, E. Madej, J. Dąbrowski, P. M. Płonka
    Book:
    Rozwój nowoczesnych metod terapeutycznych w leczeniu czerniaka - mechanizmy molekularne i zastosowanie kliniczne (rok: 2022, tom: 1, strony: 182), Wydawca: Wydawnictwo Naukowe TYGIEL
    Status:
    Published
  2. Photodynamic inactivation (PDI) as a promising alternative to current pharmaceuticals for the treatment of resistant microorganisms
    Authors:
    Barbara Pucelik and Janusz M. Dąbrowski
    Book:
    Advances in Inorganic Chemistry (rok: 2022, tom: 79, strony: 65–108), Wydawca: Elsevier
    Status:
    Published
  3. Reactive Oxygen Species in Photodynamic Therapy: Mechanisms of Their Generation and Potentiation
    Authors:
    Janusz M. Dąbrowski
    Book:
    Advances in Inorganic Chemistry (rok: 2017, tom: 70, strony: 343-394), Wydawca: Elsevier
    Status:
    Published
  4. Photodynamic inactivation (PDI) as a promising alternative to current pharmaceuticals for the treatment of resistant microorganisms
    Authors:
    Barbara Pucelik and Janusz M. Dąbrowski
    Book:
    Advances in Inorganic Chemistry (rok: 2022, tom: 79, strony: 65–108), Wydawca: Elsevier
    Status:
    Published

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