Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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The role of tumor microenvironment in phenotype regulation of disseminated breast cancer cells - research in vitro, in vivo and in the clinic

2016/22/E/NZ4/00664

Keywords:

breast cancer tumor microenvironment metastasis circulating tumor cells

Descriptors:

  • NZ5_3: Pathogenesis of human diseases
  • NZ5_5: Diagnostics in human diseases
  • NZ4_5: Anatomical pathology

Panel:

NZ4 - Biology of tissues, organs and organisms: morphology and functions of animal's and human's systems, organs and organisms, experimental medicine, basics of neurology

Host institution :

Gdański Uniwersytet Medyczny, Międzyuczelniany Wydział Biotechnologii Uniwersytetu Gdańskiego i Gdańskiego Uniwersytetu Medycznego

woj. pomorskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Anna Żaczek 

Number of co-investigators in the project: 13

Call: SONATA BIS 6 - announced on 2016-06-15

Amount awarded: 1 552 070 PLN

Project start date (Y-m-d): 2017-05-18

Project end date (Y-m-d): 2023-03-17

Project duration:: 70 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. System do hybrydyzacji in situ (16 000 PLN)
  2. Komputer z oprogramowaniem (13 000 PLN)
  3. System do mechanicznej dysagregacji tkanek (17 000 PLN)
  4. Zamrażarka niskotemperaturowa (45 000 PLN)

Information in the final report

  • Publication in academic press/journals (9)
  1. Higher platelet counts correlate to tumour progression and can be induced by intratumoural stroma in non-metastatic breast carcinomas
    Authors:
    8.Bednarz-Knoll N, Popęda M, Kryczka T, Kozakiewicz B, Pogoda K, Szade J, Markiewicz A, Strzemecki D, Kalinowski L, Skokowski J, Liu J, Żaczek AJ
    Academic press:
    British Journal of Cancer (rok: 2022, tom: 126(3), strony: 464-471), Wydawca: Nature
    Status:
    Published
    DOI:
    10.1038/s41416-021-01647-9 - link to the publication
  2. Alpha‑smooth muscle actin‑positive cancer‑associated fibroblasts secreting osteopontin promote growth of luminal breast cancer
    Authors:
    Muchlińska A, Nagel A, Popęda M, Szade J, Niemira M, Zieliński J, Skokowski J, Bednarz-Knoll N, Żaczek AJ
    Academic press:
    Cellular & Molecular Biology Letters (rok: 2022, tom: 27(1), strony: 45), Wydawca: BioMed Central, Springer NAture
    Status:
    Published
    DOI:
    10.1186/s11658-022-00351-7 - link to the publication
  3. Circulating Tumor Cells in Early and Advanced Breast Cancer; Biology and Prognostic Value
    Authors:
    Anna Fabisiewicz, Malgorzata Szostakowska-Rodzos, Anna J. Zaczek, Ewa A. Grzybowska
    Academic press:
    International Journal of Molecular Sciences (rok: 2020, tom: 21, strony: 1671), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms21051671 - link to the publication
  4. NF-kappa B Signaling-Related Signatures Are Connected with the Mesenchymal Phenotype of Circulating Tumor Cells in Non-Metastatic Breast Cancer
    Authors:
    Popeda, M.; Stokowy, T.; Bednarz-Knoll, N.; Jurek, A.; Niemira, M.; Bielska, A.; Kretowski, A.; Kalinowski, L.; Szade, J.; Markiewicz, A.; Zaczek, AJ
    Academic press:
    Cancers (rok: 2019, tom: 11, strony: 1961), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/cancers11121961 - link to the publication
  5. ERα36-High Cancer-Associated Fibroblasts as an Unfavorable Factor in Triple-Negative Breast Cancer
    Authors:
    Nagel A, Popeda M, Muchlinska A, Sadej R, Szade J, Zielinski J, Skokowski J, Niemira M, Kretowski A, Markiewicz A, Zaczek AJ.
    Academic press:
    Cancers (rok: 2022, tom: 14(8), strony: 2005), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/cancers14082005 - link to the publication
  6. Reduced expression of innate immunity-related genes in lymph node metastases of luminal breast cancer patients
    Authors:
    Popęda M, Markiewicz A, Stokowy T, Szade J, Niemira M, Kretowski A, Bednarz-Knoll N, Żaczek AJ.
    Academic press:
    Scientific Reports (rok: 2021, tom: 11(1), strony: 5097), Wydawca: grupa Nature
    Status:
    Published
    DOI:
    10.1038/s41598-021-84568-0 - link to the publication
  7. Spectrum of Epithelial-Mesenchymal Transition Phenotypes in Circulating Tumour Cells from Early Breast Cancer Patients
    Authors:
    Markiewicz A, Topa J, Nagel A, Skokowski J, Seroczynska B, Stokowy T, Welnicka-Jaskiewicz M, Zaczek AJ
    Academic press:
    Cancers (rok: 2019, tom: 11, strony: 59), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/cancers11010059 - link to the publication
  8. Activation of epithelial-mesenchymal transition process during breast cancer progression - the impact of molecular subtype and stromal composition
    Authors:
    Markiewicz A, Topa J, Popęda M, Szade J, Skokowski J, Wełnicka-Jaśkiewicz M, Żaczek A
    Academic press:
    Acta Biochim Polonica (rok: 2021, tom: 68 (3), strony: 385–392), Wydawca: Polish Biochemical Society
    Status:
    Published
    DOI:
    10.18388/abp.2020_5719 - link to the publication
  9. Aggressive Phenotype of Cells Disseminated via Hematogenous and Lymphatic Route in Breast Cancer Patients
    Authors:
    Markiewicz A, Nagel A, Szade J, Majewska H, Skokowski J, Seroczynska B, Stokowy T, Welnicka-Jaskiewicz M, Zaczek AJ
    Academic press:
    Translational Oncology (rok: 2018, tom: 11, strony: 722-731), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.tranon.2018.03.006 - link to the publication

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